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Information on EC 4.2.3.130 - tetraprenyl-beta-curcumene synthase and Organism(s) Bacillus subtilis and UniProt Accession O34707

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.130 tetraprenyl-beta-curcumene synthase
IUBMB Comments
Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species.
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This record set is specific for:
Bacillus subtilis
UNIPROT: O34707
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The taxonomic range for the selected organisms is: Bacillus subtilis
The enzyme appears in selected viruses and cellular organisms
Synonyms
bmetc, sesterterpene/triterpene/sesquarterpene synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-beta-curcumene-forming)
Isolated from Bacillus subtilis. This sesquarterpene is present in a number of Bacillus species.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
all-trans-heptaprenyl diphosphate
tetraprenyl-beta-curcumene + diphosphate
show the reaction diagram
-
-
tetraprenyl-beta-curcumene shows nonenzymatic autooxidation to tetraprenyl-alpha-curcumene
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
all-trans-heptaprenyl diphosphate
tetraprenyl-beta-curcumene + diphosphate
show the reaction diagram
-
-
-
-
?
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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the ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant fusion protein YtpB from Escherichia coli strain BL21(DE3) by affinity chromatography
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene ytpB, expression as fusion protein in Escherichia coli strain BL21(DE3) from pColdTF. The ts gene or ytpB gene forms an operon with a lysophospholipase gene ytpA, which is responsible for the biosynthesis of the antibiotic bacilysocin in Bacillus subtilis
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sato, T.; Yoshida, S.; Hoshino, H.; Tanno, M.; Nakajima, M.; Hoshino, T.
Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-beta-curcumene synthase and a tetraprenyl-beta-curcumene cyclase: identification of a new terpene cyclase
J. Am. Chem. Soc.
133
9734-9737
2011
Bacillus subtilis
Manually annotated by BRENDA team