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Information on EC 4.2.3.124 - 2-deoxy-scyllo-inosose synthase

for references in articles please use BRENDA:EC4.2.3.124

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IUBMB Comments

Requires Co2+ . Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Requires an NAD+ cofactor, which is transiently reduced during the reaction [1,4]. The enzyme from the bacterium Bacillus circulans forms a complex with the glutamine amidotransferase subunit of pyridoxal 5'-phosphate synthase (EC 4.3.3.6), which appears to stabilize the complex [6,7].

The enzyme appears in viruses and cellular organisms

Synonyms
2-deoxy-scyllo-inosose synthase, btrc2, doi synthase, alloh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate
show the reaction diagram