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Information on EC 4.2.3.110 - (+)-sabinene synthase and Organism(s) Picea sitchensis and UniProt Accession F1CKJ1

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.110 (+)-sabinene synthase
IUBMB Comments
Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 gamma-terpinene synthase.
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This record set is specific for:
Picea sitchensis
UNIPROT: F1CKJ1
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Word Map
The taxonomic range for the selected organisms is: Picea sitchensis
The enzyme appears in selected viruses and cellular organisms
Synonyms
(+)-sabinene synthase, mktps1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranyl diphosphate = (+)-sabinene + diphosphate
show the reaction diagram
proposed reaction mechanism of sabinene synthase via (3R)-3-linalyl diphosphate and (3R)-3-alpha-terpinyl cation
SYSTEMATIC NAME
IUBMB Comments
geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-sabinene-forming]
Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 gamma-terpinene synthase.
CAS REGISTRY NUMBER
COMMENTARY hide
141907-26-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate
(+)-sabinene + diphosphate
show the reaction diagram
-
-
-
?
additional information
?
-
the enzyme produces also (-)-sabinene
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate
(+)-sabinene + diphosphate
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SSS_PICSI
627
0
71795
Swiss-Prot
Chloroplast (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
strategies in engineering sabinene production, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
sequence comparisons and phylogenetic analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cao, Y.; Zhang, H.; Liu, H.; Liu, W.; Zhang, R.; Xian, M.; Liu, H.
Biosynthesis and production of sabinene current state and perspectives
Appl. Microbiol. Biotechnol.
102
1535-1544
2018
Citrus jambhiri, Citrus unshiu, Hedychium coronarium, Murraya koenigii (A0A1U9M7Y9), Phomopsis sp. EC-4, Picea sitchensis (F1CKJ1), Salvia officinalis (O81193), Salvia pomifera (A6XH06), Thuja plicata (R9WS05)
Manually annotated by BRENDA team