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Information on EC 4.2.3.108 - 1,8-cineole synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.108 1,8-cineole synthase
IUBMB Comments
Requires Mn2+ or Zn2+. Mg2+ is less effective than either. 1,8-Cineole is the main product from the enzyme with just traces of other monoterpenoids. The oxygen atom is derived from water. The reaction proceeds via linalyl diphosphate and alpha-terpineol, the stereochemistry of both depends on the organism. However neither intermediate can substitute for geranyl diphosphate. The reaction in Salvia officinalis (sage) proceeds via (-)-(3R)-linalyl diphosphate [1-3] while that in Arabidopsis (rock cress) proceeds via (+)-(3S)-linalyl diphosphate .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
1,8-cineole cyclase; geranyl pyrophoshate:1,8-cineole cyclase, 1,8-cineole synthetase, AaTPS6, CIN, CinS, leucoplast 1,8-cineole synthase, LnTPS1, plastid terpineol synthase, SabS1, SCLAV_p0982, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranyl diphosphate + H2O = 1,8-cineole + diphosphate
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