Disease on EC 4.2.2.8 - heparin-sulfate lyase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma
Sialoglycopeptides obtained from a transplantable rat colorectal adenocarcinoma: a comparison with those from normal colonic mucosa.
Albuminuria
Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis.
Albuminuria
Removal of heparan sulfate from the glomerular basement membrane blocks protein passage.
Arthritis
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
Bone Resorption
J774A.1 macrophage cell line produces PDGF-like and non-PDGF-like growth factors for bone cells.
Carcinoma
Ovarian carcinoma cells synthesize both chondroitin sulfate and heparan sulfate cell surface proteoglycans that mediate cell adhesion to interstitial matrix.
Carcinoma
VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
Carcinoma, Hepatocellular
Degradative removal of heparan sulfate from the surface of an ascites hepatoma, AH 66, by heparitinase.
Corneal Dystrophies, Hereditary
Abnormal product of corneal explants from patients with macular corneal dystrophy.
Dengue
Internalization and propagation of the dengue virus in human hepatoma (HepG2) cells.
Dengue
Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors.
Glaucoma
Flicker defined form perimetry in glaucoma suspects with normal achromatic visual fields.
Infections
Cell membrane bound N-acetylneuraminic acid is involved in the infection of fibroblasts and phorbol-ester differentiated monocyte-like cells with human cytomegalovirus (HCMV).
Infections
Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes.
Infections
Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines.
Infections
Cellular invasion of Orientia tsutsugamushi requires initial interaction with cell surface heparan sulfate.
Infections
Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.
Infections
Membrane-associated heparan sulfate is not required for rAAV-2 infection of human respiratory epithelia.
Infections
Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors.
Infections
Primary attachment of murine leukaemia virus vector mediated by particle-associated heparan sulfate proteoglycan.
Infections
Role of cell surface glycosaminoglycans of human T cells in human immunodeficiency virus type-1 (HIV-1) infection.
Infections
Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus.
Infections
Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae.
Infections
The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding.
Measles
Analysis of the molecules involved in human T-cell leukaemia virus type 1 entry by a vesicular stomatitis virus pseudotype bearing its envelope glycoproteins.
Melanoma
A synthetic peptide from the heparin-binding domain III (repeats III4-5) of fibronectin promotes stress-fibre and focal-adhesion formation in melanoma cells.
Melanoma
Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide.
Melanoma
Glycosaminoglycans of cultured human fetal uveal melanocytes and comparison with those produced by cultured human melanoma cells.
Neoplasm Metastasis
Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
Neoplasm Metastasis
Partial sequence of human platelet heparitinase and evidence of its ability to polymerize.
Neoplasm Metastasis
Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis.
Neoplasms
Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
Neoplasms
Expression of N-CAM by human renal cell carcinomas correlates with growth rate and adhesive properties.
Neoplasms
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
Neoplasms
Interference with tumor cell-induced degradation of endothelial matrix on the antimetastatic action of nafazatrom.
Neoplasms
Partial characterization of proteoglycans synthesized by human glomerular epithelial cells in culture.
Neoplasms
Partial sequence of human platelet heparitinase and evidence of its ability to polymerize.
Neoplasms
Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis.
Neoplasms
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Neuroblastoma
A cell-surface heparan sulfate proteoglycan mediates neural cell adhesion and spreading on a defined sequence from the C-terminal cell and heparin binding domain of fibronectin, FN-C/H II.
Ovarian Neoplasms
[Hypoxia increases the expression of heparitinase and the invasiveness through the hypoxia inducible factor-1alpha dependent pathway in human ovarian cancer cell line SKOV3]
Reperfusion Injury
Heparinase III exerts endothelial and cardioprotective effects in feline myocardial ischemia-reperfusion injury.
Scleroderma, Diffuse
Compositional changes of urinary acidic glycosaminoglycans in progressive systemic sclerosis.
Thrombasthenia
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
Trachoma
Chlamydia trachomatis glycosaminoglycan-dependent and independent attachment to eukaryotic cells.
Virus Diseases
Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37.
html completed