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Information on EC 4.2.2.13 - exo-(1->4)-alpha-D-glucan lyase

for references in articles please use BRENDA:EC4.2.2.13

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IUBMB Comments

The enzyme catalyses the sequential degradation of (1→4)-α-D-glucans from the non-reducing end with the release of 1,5-anhydro-D-fructose. Thus, for an α-glucan containing n (1→4)-linked glucose units, the final products are 1 glucose plus (n-1) 1,5-anhydro-D-fructose. Maltose, maltosaccharides and amylose are all completely degraded. It does not degrade (1→6)-α-glucosidic bonds and thus the degradation of a branched glucan, such as amylopectin or glycogen, will result in the formation of 1,5-anhydro-D-fructose plus a limit dextrin. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.1.111 (1,5-anhydro-D-fructose dehydratase) and EC 5.3.2.7 (ascopyrone tautomerase).

The enzyme appears in viruses and cellular organisms

Synonyms
glase, alpha-1,4-glucan lyase, ag111, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[(1->4)-alpha-D-glucosyl]n+1 = 1,5-anhydro-D-fructose + [(1->4)-alpha-D-glucosyl]n
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
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