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Information on EC 4.2.2.1 - hyaluronate lyase and Organism(s) Clostridium perfringens and UniProt Accession P26831

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.2 Acting on polysaccharides
                4.2.2.1 hyaluronate lyase
IUBMB Comments
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
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This record set is specific for:
Clostridium perfringens
UNIPROT: P26831
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Word Map
The taxonomic range for the selected organisms is: Clostridium perfringens
The enzyme appears in selected viruses and cellular organisms
Synonyms
hyaluronate lyase, mucinase, hylp2, hyaluronan lyase, bacterial hyaluronidase, hyaluronidase sd, ha lyase, spnhl, hylb4755, bacterial spreading factor, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glucuronoglycosaminoglycan lyase
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hyaluronidase
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HYase
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lyase, glucuronoglycosaminoglycan
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lyase, hyaluronate
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mucinase
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spreading factor
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
show the reaction diagram
also acts on chondroitin, the product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
hyaluronate lyase
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
CAS REGISTRY NUMBER
COMMENTARY hide
37259-53-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hyaluronate
3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
show the reaction diagram
eliminative reaction, degradation
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?
additional information
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phylogenetic analysis, enzyme is the non-lethal Mu toxin, causes gas gangrene, produces many extracellular proteins during infection that are potetial virulence factors
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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phylogenetic analysis, enzyme is the non-lethal Mu toxin, causes gas gangrene, produces many extracellular proteins during infection that are potetial virulence factors
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
114000
x * 114000, amino acid sequence calculation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 114000, amino acid sequence calculation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hynes, W.L.; Walton, S.L.
Hyaluronidases of Gram-positive bacteria
FEMS Microbiol. Lett.
183
201-207
2000
Aeromonas sp., Bacteroides fragilis, Bacteroides ovatus, Candida albicans, Candida parapsilosis, Candida tropicalis, Clostridioides difficile, Clostridium chauvoei, Clostridium perfringens (P26831), Clostridium septicum, Cutibacterium acnes (P0CZ01), Cutibacterium granulosum, Fusobacterium mortiferum, Meyerozyma guilliermondii, Phocaeicola vulgatus, Pichia kudriavzevii, Porphyromonas asaccharolytica, Prevotella melaninogenica, Staphylococcus aureus (Q59801), Staphylococcus hyicus, Streptococcus agalactiae (O86478), Streptococcus constellatus, Streptococcus dysgalactiae, Streptococcus equi, Streptococcus intermedius, Streptococcus pneumoniae (Q54873), Streptococcus pyogenes, Streptococcus uberis, Streptomyces coelicolor, Streptomyces griseus (Q9WXL3), Streptomyces hyalurolyticus, Treponema pallidum, Treponema pallidum subsp. pertenue
Manually annotated by BRENDA team