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EC Tree
IUBMB Comments The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia.
The expected taxonomic range for this enzyme is: Pseudomonas aeruginosa
Synonyms
dehydratase, octopamine, OCAH, octopamine hydrolyase,
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dehydratase, octopamine
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octopamine hydrolyase
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1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3
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C-O bond cleavage by elimination of water
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1-(4-hydroxyphenyl)-2-aminoethanol hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]
The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia.
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norepinephrine
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octopamine
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O
additional information
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not: phenethylamines, e.g. tyramine and dopamine
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octopamine
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O
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i.e. 1-(4-hydroxyphenyl)-2-aminoethanol, oxygen-independent reaction, proposed mechanism: dehydration to an enamine and hydrolysis to an aldehyde and NH3
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octopamine
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O
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initial catabolism of octopamine
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octopamine
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O
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initial catabolism of octopamine
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additional information
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enzyme is only induced by growth with phenethanolamines
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additional information
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brenda
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Cuskey, S.M.; Peccoraro, V.; Olsen, R.H.
Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes
J. Bacteriol.
169
2398-2404
1987
Pseudomonas aeruginosa
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