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Information on EC 4.2.1.78 - (S)-norcoclaurine synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.78 (S)-norcoclaurine synthase
IUBMB Comments
The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.
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Word Map
  • 4.2.1.78
  • nanocrystals
  • nerve
  • nanoclusters
  • colloidal
  • photoluminescence
  • fabric
  • semiconductor
  • neuropathy
  • luminescence
  • film
  • dope
  • nanocomposites
  • neocarzinostatin
  • carpal
  • doping
  • nanomaterials
  • as-prepared
  • tunable
  • optoelectronic
  • solar
  • nanostructures
  • monodisperse
  • biocompatibility
  • alloy
  • nanocapsules
  • electrocatalytic
  • ulnar
  • near-infrared
  • polyneuropathy
  • photocatalytic
  • nanocarriers
  • excitons
  • sural
  • photovoltaic
  • photoelectron
  • core-shell
  • bimetallic
  • head-up
  • light-emitting
  • bioimaging
  • syncope
  • photothermal
  • nanorods
  • photostability
  • indium
  • photocurrent
  • synthesis
  • peroneal
  • nanosheets
  • recoverins
  • cmaps
The enzyme appears in viruses and cellular organisms
Synonyms
ncs, norcoclaurine synthase, pr10a, cjncs1, cjpr10a, (s)-norlaudanosoline synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxyphenylacetaldehyde + dopamine = (S)-norcoclaurine + H2O
show the reaction diagram
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