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(2-fluorophenyl)acetaldehyde + dopamine
(1S)-1-[2-(2-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
65% conversion after 3 h
-
-
?
(2-methylphenyl)acetaldehyde + dopamine
(1S)-1-[2-(2-methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
66% conversion after 3 h
-
-
?
(3,4-dimethoxyphenyl)acetaldehyde + dopamine
(1S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
69% conversion after 3 h
-
-
?
(3-fluorophenyl)acetaldehyde + dopamine
(1S)-1-[2-(3-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
66% conversion after 3 h
-
-
?
(3-methylphenyl)acetaldehyde + dopamine
(1S)-1-[2-(3-methylphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
58% conversion after 3 h
-
-
?
(4-fluorophenyl)acetaldehyde + dopamine
(1S)-1-[2-(4-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
71% conversion after 3 h
-
-
?
(4-methoxyphenyl)acetaldehyde + dopamine
(1S)-1-[2-(4-methoxyphenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
69% conversion after 3 h
-
-
?
(4-methylphenyl)acetaldehyde + dopamine
(1S)-1-[2-(4-fluorophenyl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
57% conversion after 3 h
-
-
?
(5,5-dimethyl-1,3-dioxan-2-yl)acetaldehyde + dopamine
(1S)-1-[2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
42% conversion after 3 h
-
-
?
1-butylaldehyde + dopamine
6,7-dihydroxy-1-propyl-1,2,3,4-tetrahydroisoquinoline
molar yield and enantiomeric excess of 6,7-dihydroxy-1-phenethyl-1,2,3,4-tetrahydroisoquinoline are 99.6 and 98.0 %, respectively
-
-
?
3,3-dimethylbutanal + dopamine
(1S)-1-(3,3-dimethylbutyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
52% conversion after 3 h
-
-
?
3-(2-aminoethyl)phenol + 4-hydroxyphenylacetaldehyde
?
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde
?
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
4-hydroxyphenylacetone + dopamine
1-(4-hydroxybenzyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
-
-
-
?
5-(2-aminoethyl)-2-methoxyphenol + 4-hydroxyphenylacetaldehyde
?
-
-
-
-
?
cyclohexylacetaldehyde + dopamine
(1S)-1-(2-cyclohexylethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
71% conversion after 3 h
-
-
?
hydrocinnamaldehyde + dopamine
6,7-dihydroxy-1-phenethyl-1,2,3,4-tetrahydroisoquinoline
molar yield and enantiomeric excess of 6,7-dihydroxy-1-phenethyl-1,2,3,4-tetrahydroisoquinoline are 86.0 and 95.3%, respectively
-
-
?
naphthalen-1-ylacetaldehyde + dopamine
(1S)-1-[2-(naphthalen-1-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
61% conversion after 3 h
-
-
?
phenylacetaldehyde + dopamine
(1S)-1-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
51% conversion after 3 h
-
-
?
thiophen-3-ylacetaldehyde + dopamine
(1S)-1-[2-(thiophen-3-yl)ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
68% conversion after 3 h
-
-
?
[4-(trifluoromethoxy)phenyl]acetaldehyde + dopamine
(1S)-1-[2-[4-(trifluoromethoxy)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol + H2O
-
65% conversion after 3 h
-
-
?
additional information
?
-
-
isozyme NCS1 of Coptis japonica does not catalyze the formation of (S)-norcoclaurine from dopamine and 4-hydroxyphenylacetaldehyde
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Berberis regeliana
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Eschscholtzia tenuifolia
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Eschscholtzia tenuifolia
-
i.e. dopamine + 3,4-dihydroxyphenylacetaldehyde, , 3,4-dihydroxyphenylacetaldehyde can be substituted by 4-hydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Eschscholzia pulchella
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Glaucium rubrum
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
Thalictrum flavum ssp. glaucum
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
?
4-(2-aminoethyl)benzene-1,2-diol + 3,4-dihydroxyphenylacetaldehyde
(S)-norlaudanosoline + H2O
-
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
CjNCS1
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
CjPR10A
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Eschscholtzia tenuifolia
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Eschscholtzia tenuifolia
-
i.e. dopamine + 4-hydroxyphenylacetaldehyde, , 4-hydroxyphenylacetaldehyde can be substituted by 3,4-dihydroxyphenylacetaldehyde but not by 3,4-dihydroxyphenylpyruvate, 4-hydroxyphenylpyruvate or phenylpyruvate
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol is dopmaine
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol is dopmaine
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
the enzyme is involved in the plants secondary metabolism and is required for the production of bioactive secondary metabolites like morphine
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
4-(2-aminoethyl)benzene-1,2-diol is dopmaine
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
4-(2-aminoethyl)benzene-1,2-diol is dopmaine, cooperativity between the dopamine binding sites on each subunit
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Berberis regeliana
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Eschscholtzia tenuifolia
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Eschscholzia pulchella
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Glaucium rubrum
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
stereospecific formation of the (S)-norcolaurine enantiomer by the recombinant enzyme, overview
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the stereoselective Pictet-Spengler reaction between dopamine and 4-hydroxyphenylacetaldehyde as a step of benzylisoquinoline alkaloid synthesis in plants
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
Corydalis chinensis
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
Corydalis chinensis
-
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
60% conversion after 3 h
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
-
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
-
the enzyme is involved in the plants secondary metabolism and is required for the production of bioactive secondary metabolites like morphine
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
(S)-Norcoclaurine + H2O
Thalictrum flavum ssp. glaucum
-
first step of benzylisoquinoline alkaloid synthesis, enzyme might play a regulatory or rate-limiting role in controlling the rate of pathway flux
-
ir
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Berberis regeliana
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Eschscholtzia tenuifolia
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Eschscholzia pulchella
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
Glaucium rubrum
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-(2-Aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde
?
-
initial reaction in isoquinoline biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
4-(2-aminoethyl)benzene-1,2-diol, i.e. dopamine
-
-
?
4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol
(S)-norcoclaurine + H2O
-
stereospecific formation of the (S)-norcolaurine enantiomer by the recombinant enzyme, overview
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
-
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the stereoselective Pictet-Spengler reaction between dopamine and 4-hydroxyphenylacetaldehyde as a step of benzylisoquinoline alkaloid synthesis in plants
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
Corydalis chinensis
-
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme is involved in the biosynthesis of benzylisoquinoline
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-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
-
60% conversion after 3 h
-
-
?
4-hydroxyphenylacetaldehyde + dopamine
(S)-norcoclaurine + H2O
the enzyme catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as a step in benzylisoquinoline alkaloid biosynthesis
-
-
?
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4.2.1.78 (S)-norcoclaurine synthase
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