Information on EC 4.2.1.77 - trans-L-3-hydroxyproline dehydratase

for references in articles please use BRENDA:EC4.2.1.77
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The expected taxonomic range for this enzyme is: Eukaryota, Archaea

top print hide
EC NUMBER
COMMENTARY hide
4.2.1.77
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RECOMMENDED NAME
GeneOntology No.
trans-L-3-hydroxyproline dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O
show the reaction diagram
highly specific, 2,3-dehydroproline is an intermediate
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-
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top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
trans-3-hydroxy-L-proline degradation
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-
Arginine and proline metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline-2-carboxylate-forming)
Highly specific.
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top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trans-3-hydroxy-L-proline
1-pyrroline 2-carboxylate + H2O
show the reaction diagram
trans-L-3-Hydroxyproline
?
show the reaction diagram
-
-
-
-
-
trans-L-3-Hydroxyproline
DELTA1-Pyrroline-2-carboxylate
show the reaction diagram
-
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
trans-3-hydroxy-L-proline
1-pyrroline 2-carboxylate + H2O
show the reaction diagram
trans-L-3-Hydroxyproline
?
show the reaction diagram
-
-
-
-
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.67
trans-L-3-hydroxyproline
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-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.1 - 8.3
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-
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
top print hide
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
top print hide
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
top print hide
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.1.77)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)