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Information on EC 4.2.1.75 - uroporphyrinogen-III synthase and Organism(s) Danio rerio and UniProt Accession Q1ET39

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.75 uroporphyrinogen-III synthase
IUBMB Comments
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen.
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This record set is specific for:
Danio rerio
UNIPROT: Q1ET39
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
uros, uroporphyrinogen iii synthase, porphobilinogenase, uro-synthase, uroiiis, uroporphyrinogen iii cosynthase, u3s, uro synthase, uroporphyrinogen-iii synthase, uro'gen iii synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Uroporphyrinogen III synthase
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Hydroxymethylbilane hydrolyase [cyclizing]
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-
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Isomerase, uroporphyrinogen
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Porphobilinogenase
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-
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Synthase, uroporphyrinogen III co-
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URO-synthase
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-
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UROIIIS
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-
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Uroporphyrinogen III co-synthase
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Uroporphyrinogen III cosynthase
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Uroporphyrinogen III synthase
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-
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Uroporphyrinogen isomerase
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Uroporphyrinogen-III cosynthase
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Uroporphyrinogen-III cosynthetase
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-
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UROS
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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SYSTEMATIC NAME
IUBMB Comments
hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen.
CAS REGISTRY NUMBER
COMMENTARY hide
37340-55-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
uroporphyrinogen III synthase forms pairs of bilateral stripes in the lateral mesoderm at the 15-somite stage. At 24 h post-fertilization, uroporphyrinogen III synthase is predominantly expressed in the intermediate cell mass (ICM) that is the major site of hematopoiesis. The expression is drastically suppressed in the bloodless mutants cloche and vlad tepes/gata 1 from 15-somite to 24hpf stages, indicating that both cloche abd vlad tepes/gata 1 are required for the induction and maitenance of uroporphyrinogen III synthase expression in intermediate cell mass
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q1ET39_DANRE
262
0
28835
TrEMBL
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hanaoka, R.; Dawid, I.B.; Kawahara, A.
Cloning and expression of zebrafish genes encoding the heme synthesis enzymes uroporphyrinogen III synthase (UROS) and protoporphyrinogen oxidase (PPO)
DNA Seq.
18
54-60
2007
Danio rerio (Q1ET39), Danio rerio
Manually annotated by BRENDA team