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Information on EC 4.2.1.70 - pseudouridylate synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.70 pseudouridylate synthase
IUBMB Comments
The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
16S pseudouridine 516 synthase, 16S pseudouridylate 516 synthase, 5-ribosyluracil 5'-phosphate synthetase, Depressed growth-RATE protein DEG1, IndA, More, ORP protein, Osmoprotectant regulator of PLC, P35 protein, pseudouridine monophosphate synthetase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O
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PATHWAY SOURCE
PATHWAYS
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