Information on EC 4.2.1.56 - Itaconyl-CoA hydratase

for references in articles please use BRENDA:EC4.2.1.56
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
4.2.1.56
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RECOMMENDED NAME
GeneOntology No.
Itaconyl-CoA hydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Citramalyl-CoA = itaconyl-CoA + H2O
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
itaconate degradation
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C5-Branched dibasic acid metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
37290-83-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-citramalyl-CoA
itaconyl-CoA + H2O
show the reaction diagram
itaconyl-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
Itaconyl-CoA + H2O
?
show the reaction diagram
Itaconyl-CoA + H2O
Citramalyl-CoA
show the reaction diagram
mesaconyl-C4-CoA + H2O
itaconyl-CoA
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
itaconyl-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
Itaconyl-CoA + H2O
?
show the reaction diagram
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.14 - 0.49
(S)-citramalyl-CoA
0.034 - 0.12
itaconyl-CoA
0.31 - 0.51
mesaconyl-C4-CoA
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.4 - 415.4
(S)-citramalyl-CoA
52.2 - 415
itaconyl-CoA
98.8 - 4651
mesaconyl-C4-CoA
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.1.56)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)