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Information on EC 4.2.1.56 - itaconyl-CoA hydratase for references in articles please use BRENDA:EC4.2.1.56
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EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
Hydratase, itaconyl coenzyme A, ICH, IchA, Itaconyl coenzyme A hydratase, Itaconyl-CoA hydratase, RipB,
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Hydratase, itaconyl coenzyme A
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Itaconyl coenzyme A hydratase
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Itaconyl-CoA hydratase
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ICH
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IchA
A0A172ML99
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RipB
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Citramalyl-CoA = itaconyl-CoA + H2O
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citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
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(S)-citramalyl-CoA
itaconyl-CoA + H2O
itaconyl-CoA + H2O
(S)-citramalyl-CoA
Itaconyl-CoA + H2O
Citramalyl-CoA
mesaconyl-C4-CoA + H2O
itaconyl-CoA
(S)-citramalyl-CoA
itaconyl-CoA + H2O
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r
(S)-citramalyl-CoA
itaconyl-CoA + H2O
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r
(S)-citramalyl-CoA
itaconyl-CoA + H2O
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r
(S)-citramalyl-CoA
itaconyl-CoA + H2O
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
Itaconyl-CoA + H2O
?
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enzyme is involved in itaconate catabolism
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Itaconyl-CoA + H2O
?
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enzyme is involved in itaconate catabolism
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Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
the enzyme is involved in the catabolic pathway of itaconic acid. Although Aspergillus terreus LYT10 can catabolize itaconic acid, it cannot grow in the medium using itaconic acid (with concentrations from 5 to 40 g/l) as the sole carbon source
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
the enzyme is involved in the catabolic pathway of itaconic acid. Although Aspergillus terreus LYT10 can catabolize itaconic acid, it cannot grow in the medium using itaconic acid (with concentrations from 5 to 40 g/l) as the sole carbon source
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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the enzyme is involved in the degradation of itaconate
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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the enzyme is involved in the degradation of itaconate
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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Itaconyl-CoA + H2O
Citramalyl-CoA
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mesaconyl-C4-CoA + H2O
itaconyl-CoA
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r
mesaconyl-C4-CoA + H2O
itaconyl-CoA
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r
mesaconyl-C4-CoA + H2O
itaconyl-CoA
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r
mesaconyl-C4-CoA + H2O
itaconyl-CoA
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r
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itaconyl-CoA + H2O
(S)-citramalyl-CoA
Itaconyl-CoA + H2O
Citramalyl-CoA
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
itaconyl-CoA + H2O
(S)-citramalyl-CoA
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r
Itaconyl-CoA + H2O
?
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enzyme is involved in itaconate catabolism
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Itaconyl-CoA + H2O
?
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enzyme is involved in itaconate catabolism
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Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
the enzyme is involved in the catabolic pathway of itaconic acid. Although Aspergillus terreus LYT10 can catabolize itaconic acid, it cannot grow in the medium using itaconic acid (with concentrations from 5 to 40 g/l) as the sole carbon source
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-
?
Itaconyl-CoA + H2O
Citramalyl-CoA
A0A172ML99
the enzyme is involved in the catabolic pathway of itaconic acid. Although Aspergillus terreus LYT10 can catabolize itaconic acid, it cannot grow in the medium using itaconic acid (with concentrations from 5 to 40 g/l) as the sole carbon source
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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the enzyme is involved in the degradation of itaconate
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?
Itaconyl-CoA + H2O
Citramalyl-CoA
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the enzyme is involved in the degradation of itaconate
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?
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additional information
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the enzyme does not require divalent metal ions
additional information
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the enzyme does not require divalent metal ions
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0.14 - 0.49
(S)-citramalyl-CoA
0.034 - 0.12
itaconyl-CoA
0.31 - 0.51
mesaconyl-C4-CoA
0.14
(S)-citramalyl-CoA
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at pH 7.5 and 45°C
0.49
(S)-citramalyl-CoA
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at pH 7.5 and 45°C
0.034
itaconyl-CoA
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at pH 7.5 and 45°C
0.12
itaconyl-CoA
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at pH 7.5 and 45°C
0.31
mesaconyl-C4-CoA
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at pH 7.5 and 45°C
0.51
mesaconyl-C4-CoA
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at pH 7.5 and 45°C
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4.4 - 415.4
(S)-citramalyl-CoA
98.8 - 4651
mesaconyl-C4-CoA
4.4
(S)-citramalyl-CoA
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at pH 7.5 and 45°C
415.4
(S)-citramalyl-CoA
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at pH 7.5 and 45°C
52.2
itaconyl-CoA
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at pH 7.5 and 45°C
415
itaconyl-CoA
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at pH 7.5 and 45°C
98.8
mesaconyl-C4-CoA
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at pH 7.5 and 45°C
4651
mesaconyl-C4-CoA
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at pH 7.5 and 45°C
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A0A172ML99
UniProt
brenda
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A0A172ML99
UniProt
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brenda
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brenda
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brenda
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brenda
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brenda
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metabolism
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the enzyme is involved in the degradation of itaconate. Itaconyl-CoA hydratase reaction as a bottleneck in the conversion. Its activity is an order of magnitude lower than the activities of itaconate-CoA transferase and (S)-citramalyl-CoA lyase
metabolism
A0A172ML99
the enzyme is involved in the catabolic pathway of itaconic acid
metabolism
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the enzyme is involved in the catabolic pathway of itaconic acid
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metabolism
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the enzyme is involved in the degradation of itaconate. Itaconyl-CoA hydratase reaction as a bottleneck in the conversion. Its activity is an order of magnitude lower than the activities of itaconate-CoA transferase and (S)-citramalyl-CoA lyase
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AUHM_HUMAN
339
0
35609
Swiss-Prot
AUHM_MOUSE
314
0
33395
Swiss-Prot
AUHM_RAT
315
0
33341
Swiss-Prot
A0A411ZEN4_9SPHN
150
0
16553
TrEMBL
A0A1U9MFU8_9RHIZ
285
0
32220
TrEMBL
A0A411ZBL5_9SPHN
169
0
19303
TrEMBL
A0A173KRR0_9SPHN
154
0
17191
TrEMBL
A0A0B8NGJ3_9NOCA
159
0
17493
TrEMBL
A0A369Q5Y2_9SPHN
153
0
17315
TrEMBL
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expressed in Escherichia coli BL21(DE3) cells
expression in Escherichia coli BL21 (DE3)
A0A172ML99
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli BL21(DE3) cells
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high activities of itaconyl-CoA hydratase in cell extracts of itaconate-grown Paraburkholderia xenovorans
substantially downregulated in acetate-grown cells
upregulated at both transcription and protein levels, when 40 g/l of exogenous itaconic acid is added into the medium at the beginning of fermentation
high activities of itaconyl-CoA hydratase in cell extracts of itaconate-grown Paraburkholderia xenovorans
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high activities of itaconyl-CoA hydratase in cell extracts of itaconate-grown Paraburkholderia xenovorans
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substantially downregulated in acetate-grown cells
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substantially downregulated in acetate-grown cells
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upregulated at both transcription and protein levels, when 40 g/l of exogenous itaconic acid is added into the medium at the beginning of fermentation
A0A172ML99
upregulated at both transcription and protein levels, when 40 g/l of exogenous itaconic acid is added into the medium at the beginning of fermentation
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Cooper, R.A.; Kornberg, H.L.
The utilization of itaconate by Pseudomonas sp.
Biochem. J.
91
82-91
1964
Pseudomonas sp.
brenda
Sasikaran, J.; Ziemski, M.; Zadora, P.K.; Fleig, A.; Berg, I.A.
Bacterial itaconate degradation promotes pathogenicity
Nat. Chem. Biol.
10
371-377
2014
Pseudomonas aeruginosa, Pseudomonas aeruginosa PA0878, Yersinia pestis, Yersinia pestis Y2384
brenda
Kronen, M.; Sasikaran, J.; Berg, I.A.
Mesaconase activity of class I fumarase contributes to mesaconate utilization by Burkholderia xenovorans
Appl. Environ. Microbiol.
81
5632-5638
2015
Paraburkholderia xenovorans, Paraburkholderia xenovorans DSMZ 17367 / LB400
brenda
Chen, M.; Huang, X.; Zhong, C.; Li, J.; Lu, X.
Identification of an itaconic acid degrading pathway in itaconic acid producing Aspergillus terreus
Appl. Microbiol. Biotechnol.
100
7541-7548
2016
Aspergillus terreus (A0A172ML99), Aspergillus terreus, Aspergillus terreus LYT10 (A0A172ML99)
brenda
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4.2.1.56 itaconyl-CoA hydratase
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