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Information on EC - GDP-mannose 4,6-dehydratase

for references in articles please use BRENDA:EC4.2.1.47
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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
       GDP-mannose 4,6-dehydratase
IUBMB Comments
The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC, GDP-4-dehydro-6-deoxy-D-mannose reductase . Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues .
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The enzyme appears in viruses and cellular organisms
gdp-mannose dehydrogenase, gdp-mannose 4,6-dehydratase, gdp-d-mannose 4,6-dehydratase, gdp-d-mannose-4,6-dehydratase, gdp-mannose-4,6-dehydratase, gdp-mannose dehydratase, gdp-mannose 4,6 dehydratase, gdp-d-mannose dehydratase, pbcv-1 gmd, m-gmd, more
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O
show the reaction diagram
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