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Information on EC 4.2.1.47 - GDP-mannose 4,6-dehydratase

for references in articles please use BRENDA:EC4.2.1.47

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IUBMB Comments

The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-α-D-rhamnose and GDP-β-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase . Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues .

The enzyme appears in viruses and cellular organisms

Synonyms
gdp-mannose dehydrogenase, gdp-mannose 4,6-dehydratase, gdp-d-mannose 4,6-dehydratase, gdp-d-mannose-4,6-dehydratase, gdp-mannose-4,6-dehydratase, gdp-mannose dehydratase, gdp-mannose 4,6 dehydratase, gdp-d-mannose dehydratase, pbcv-1 gmd, m-gmd, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
GDP-6-deoxy-D-talose biosynthesis, GDP-D-perosamine biosynthesis, GDP-D-rhamnose biosynthesis, GDP-L-colitose biosynthesis, GDP-L-fucose biosynthesis I (from GDP-D-mannose), GDP-mycosamine biosynthesis, GDP-N-acetyl-alpha-D-perosamine biosynthesis, GDP-N-formyl-alpha-D-perosamine biosynthesis