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Information on EC 4.2.1.27 - acetylenecarboxylate hydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.27 acetylenecarboxylate hydratase
IUBMB Comments
The reaction is effectively irreversible, favouring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate. The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate. It is thus analogous to EC 4.1.1.78, acetylenedicarboxylate decarboxylase, in its mechanism.
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The expected taxonomic range for this enzyme is: Pseudomonas sp.
Reaction Schemes
Synonyms
acetylenemonocarboxylic acid hydrase, dehydratase, malonate semialdehyde, EC 4.2.1.71, malonate semialdehyde dehydratase, malonate semialdehyde dehydratase, malonate semialdehyde, malonate-semialdehyde dehydratase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-oxopropanoate = propynoate + H2O
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