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Information on EC 4.2.1.170 - 2-(omega-methylthio)alkylmalate dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase
IUBMB Comments
The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(omega-methylsulfanyl)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.
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The expected taxonomic range for this enzyme is: Arabidopsis thaliana
Synonyms
IPMI, isopropylmalate dehydratase, isopropylmalate isomerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2-[(omega-methylsulfanyl)alkyl]malate = a 2-[(omega-methylsulfanyl)alkyl]maleate + H2O
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(1)
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0
a 3-[(omega-methylsulfanyl)alkyl]malate = a 2-[(omega-methylsulfanyl)alkyl]maleate + H2O
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(2)
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0
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