show all | hide all No of entries

Information on EC 4.2.1.166 - phosphinomethylmalate isomerase

for references in articles please use BRENDA:EC4.2.1.166
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.166 phosphinomethylmalate isomerase
IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase. The similar enzyme EC 4.2.1.3, aconitate hydratase, cannot catalyse this reaction.
Specify your search results
Select one or more organisms in this record:
The expected taxonomic range for this enzyme is: Streptomyces viridochromogenes
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
Synonyms
PMI, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-(hydroxyphosphonoylmethyl)malate = 2-(phosphinatomethylidene)butanedioate + H2O
show the reaction diagram
(1a)
-
-
-
2-(hydroxyphosphonoylmethyl)malate = 3-(hydroxyphosphonoylmethyl)malate
show the reaction diagram
overall reaction
-
-
-
2-(phosphinatomethylidene)butanedioate + H2O = 3-(hydroxyphosphonoylmethyl)malate
show the reaction diagram
(1b)
-
-
-
Select items on the left to see more content.