Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 4.2.1.140 - gluconate/galactonate dehydratase

for references in articles please use BRENDA:EC4.2.1.140

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus and via the branched variant of the Entner-Doudoroff pathway in Sulfolobus solfataricus [1,2]. In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate [1,3]. It requires Mg2+ for activity [1,2]. cf. EC 4.2.1.6, galactonate dehydratase, and EC 4.2.1.39, gluconate dehydratase.

The expected taxonomic range for this enzyme is: Archaea, Bacteria

Synonyms
sso3198, pto0485, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
show the reaction diagram
D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
show the reaction diagram
Highest Expressing Human Cell Lines
Cell Line Links Gene Links