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Information on EC 4.2.1.134 - very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
IUBMB Comments
This is the third component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
3 hydroxyacyl-CoA dehydratase, 3-hydroxyacyl-CoA dehydratase, Fatty acid elongase, fatty acyl-CoA dehydratase, HACD1, HACD2, HACD3, HACD4, HCD, PAS2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain trans-2,3-dehydroacyl-CoA + H2O
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