genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
genes encoding the tetrahymanol synthesizing enzyme squalene-tetrahymanol cyclase are found from several phylogenetically diverged eukaryotes that live in oxygen-poor environments and appear to have been laterally transferred among such eukaryotes, overview
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
tetrahymanol, a triterpenoid that does not require molecular oxygen for its biosynthesis, likely functions as a surrogate of sterol in eukaryotes inhabiting oxygen-poor environments
solubilization of the cyclase in 8 mg/ml digitonin inactivates the enzyme, its activity can be recovered by complementation of the assay buffer with octylthioglucoside above its critical micellar concentration
solubilization of the cyclase in 30 mg/ml Tween 80 inactivates the enzyme, its activity can be recovered by complementation of the assay buffer with octylthioglucoside above its critical micellar concentration
no activity in Alicyclobacillus acidocaldarius, no activity in Bradyrhizobium japonicum, no activity in Methylococcus capsulatus, no activity in Rhodopseudomonas palustris, Tetrahymena thermophila
Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen