show all | hide all No of entries

Information on EC 4.2.1.122 - tryptophan synthase (indole-salvaging)

for references in articles please use BRENDA:EC4.2.1.122
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.122 tryptophan synthase (indole-salvaging)
IUBMB Comments
Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C-(indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the alpha subunits, is transferred in an internal tunnel to the beta units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the alpha unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the beta subunit of EC 4.2.1.20.
Specify your search results
Select one or more organisms in this record:
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
Synonyms
PfTrpB, PfTrpS, StTrpS (beta2), Trp synthase, TrpB2, TrpBbeta, TRPS, tryptophan synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-serine + indole = L-tryptophan + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.