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Information on EC 4.2.1.121 - colneleate synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.121 colneleate synthase
IUBMB Comments
A heme-thiolate protein (P-450) . It catalyses the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid . It forms also (8E)-9-[(1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy]non-8-enoic acid (i.e. colnelenate) from (9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate. The corresponding 13-hydroperoxides are poor substrates [1,3]. The divinyl ethers colneleate and colnelenate have antimicrobial activity.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
9-DES, 9-divinyl ether synthase, CYP74 cytochrome P-450, CYP74D, CYP74D1, DES, DES1, divinyl ether synthase, DVE synthase, LeDES, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate = (8E)-9-[(1E,3Z)-nona-1,3-dien-1-yloxy]non-8-enoate + H2O
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PATHWAY SOURCE
PATHWAYS
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