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Information on EC 4.2.1.120 - 4-hydroxybutanoyl-CoA dehydratase

for references in articles please use BRENDA:EC4.2.1.120

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IUBMB Comments

Contains FAD and a [4Fe-4S] iron-sulfur cluster. The enzyme has been characterized from several microorganisms, including Clostridium kluyveri, where it participates in succinate fermentation [1,2], Clostridium aminobutyricum, where it participates in 4-aminobutyrate degradation [3,4], and Metallosphaera sedula, where it participates in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea .

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
4-hydroxybutyryl-coa dehydratase, 4-hydroxybutyryl-coenzyme a dehydratase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxybutanoyl-CoA = (E)-but-2-enoyl-CoA + H2O
show the reaction diagram
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