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Information on EC 4.2.1.119 - enoyl-CoA hydratase 2

for references in articles please use BRENDA:EC4.2.1.119

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IUBMB Comments

This enzyme catalyses a hydration step in peroxisomal β-oxidation. The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units . The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
hydratase 2, multifunctional enzyme type 2, phaj1, phaj4, atech2, enoyl-coa hydratase 2, phaj1pp, phaj1pa, r-hydratase, phajyb4, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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