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Information on EC 4.2.1.112 - acetylene hydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.112 acetylene hydratase
IUBMB Comments
This is a non-redox-active enzyme that contains two molybdopterin guanine dinucleotide (MGD) cofactors, a tungsten centre and a cubane type [4Fe-4S] cluster .The tungsten centre binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket . Ethylene cannot act as a substrate .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
tungsten-dependent acetylene hydratase, (e)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetaldehyde = acetylene + H2O
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