Reference on EC 4.2.1.10 - 3-dehydroquinate dehydratase and Organism(s) Helicobacter pylori and UniProt Accession Q48255
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bottomley, J.R.; Clayton, C.L.; Chalk, P.A.; Kleanthous, C.
Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori
Biochem. J.
319
559-565
1996
Helicobacter pylori
Gourley, D.G.; Shrive, A.K.; Polikarpov, I.; Krell, T.; Coggins, J.R.; Hawkins, A.R.; Isaacs, N.W.; Sawyer, L.
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction
Nat. Struct. Biol.
6
521-525
1999
Helicobacter pylori, Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis H37Rv (P9WPX7), Salmonella enterica subsp. enterica serovar Typhi, Streptomyces coelicolor
Kwak, J.E.; Lee, J.Y.; Han, B.W.; Moon, J.J.; Sohn, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of type II dehydroquinase from Helicobacter pylori
Acta Crystallogr. Sect. D
57
279-280
2001
Helicobacter pylori
Lee, B.I.; Kwak, J.E.; Suh, S.W.
Crystal structure of the type II 3-dehydroquinase from Helicobacter pylori
Proteins Struct. Funct. Genet.
51
616-617
2003
Helicobacter pylori
Robinson, D.A.; Stewart, K.A.; Price, N.C.; Chalk, P.A.; Coggins, J.R.; Lapthorn, A.J.
Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New Directions for Inhibitor Design
J. Med. Chem.
49
1282-1290
2006
Helicobacter pylori (Q48255), Helicobacter pylori
Stewart, K.A.; Robinson, D.A.; Lapthorn, A.J.
Type II dehydroquinase: molecular replacement with many copies
Acta Crystallogr. Sect. D
64
108-118
2008
Helicobacter pylori, Streptomyces coelicolor (P15474)
Liu, J.S.; Cheng, W.C.; Wang, H.J.; Chen, Y.C.; Wang, W.C.
Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase
Biochem. Biophys. Res. Commun.
373
1-7
2008
Helicobacter pylori
Sanchez-Sixto, C.; Prazeres, V.F.; Castedo, L.; Suh, S.W.; Lamb, H.; Hawkins, A.R.; Canada, F.J.; Jimenez-Barbero, J.; Gonzalez-Bello, C.
Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies
ChemMedChem
3
756-770
2008
Helicobacter pylori (Q48255), Helicobacter pylori
Prazeres, V.; Castedo, L.; Lamb, H.; Hawkins, A.; Gonzlez-Bello, C.
2-Substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase
ChemMedChem
4
1980-1984
2009
Mycobacterium tuberculosis (P9WPX7), Helicobacter pylori (Q48255), Mycobacterium tuberculosis H37Rv (P9WPX7)
Prazeres, V.F.; Tizon, L.; Otero, J.M.; Guardado-Calvo, P.; Llamas-Saiz, A.L.; van Raaij, M.J.; Castedo, L.; Lamb, H.; Hawkins, A.R.; Gonzalez-Bello, C.
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues
J. Med. Chem.
53
191-200
2010
Helicobacter pylori (Q48255), Helicobacter pylori
Peon, A.; Otero, J.M.; Tizon, L.; Prazeres, V.F.; Llamas-Saiz, A.L.; Fox, G.C.; van Raaij, M.J.; Lamb, H.; Hawkins, A.R.; Gago, F.; Castedo, L.; Gonzalez-Bello, C.
Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids
ChemMedChem
5
1726-1733
2010
Mycobacterium tuberculosis, Helicobacter pylori (Q48255), Helicobacter pylori
Tran, A.; Cergol, K.; West, N.; Randall, E.; Britton, W.; Bokhari, S.; Ibrahim, M.; Lapthorn, A.; Payne, R.
Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads
ChemMedChem
6
262-265
2011
Mycobacterium tuberculosis, Streptomyces coelicolor (P15474), Helicobacter pylori (Q48255)
Paz, S.; Tizon, L.; Otero, J.; Llamas-Saiz, A.; Fox, G.; Van Raaij, M.; Lamb, H.; Hawkins, A.; Lapthorn, A.; Castedo, L.; Gonzalez-Bello, C.
Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase
ChemMedChem
6
266-272
2011
Helicobacter pylori, Mycobacterium tuberculosis, Streptomyces coelicolor
Tran, A.; Cergol, K.; Britton, W.; Imran Bokhari, S.; Ibrahim, M.; Lapthorn, A.; Payne, R.
Rapid assembly of potent type II dehydroquinase inhibitors via 'click' chemistry
MedChemComm
1
271-275
2010
Helicobacter pylori, Mycobacterium tuberculosis, Streptomyces coelicolor
-
Coderch, C.; Lence, E.; Peon, A.; Lamb, H.; Hawkins, A.R.; Gago, F.; Gonzalez-Bello, C.
Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases
Biochem. J.
458
547-557
2014
Helicobacter pylori, Mycobacterium tuberculosis
Blanco, B.; Sedes, A.; Peon, A.; Otero, J.M.; van Raaij, M.J.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors
J. Med. Chem.
57
3494-3510
2014
Helicobacter pylori, Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis
Peon, A.; Robles, A.; Blanco, B.; Convertino, M.; Thompson, P.; Hawkins, A.R.; Caflisch, A.; Gonzalez-Bello, C.
Reducing the flexibility of type II dehydroquinase for inhibition a fragment-based approach and molecular dynamics study
ChemMedChem
12
1512-1524
2017
Helicobacter pylori (Q48255), Helicobacter pylori, Helicobacter pylori 26695 (Q48255)
Lence, E.; van der Kamp, M.W.; Gonzalez-Bello, C.; Mulholland, A.J.
QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes
Org. Biomol. Chem.
16
4443-4455
2018
Helicobacter pylori (Q48255), Helicobacter pylori, Helicobacter pylori ATCC 700392 (Q48255), Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPX7)
