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3-dehydroquinate dehydratase
3-dehydroquinate dehydratase /shikimate dehydrogenase isoform 1
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3-dehydroquinate dehydratase /shikimate dehydrogenase isoform 2
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3-dehydroquinate dehydratase/shikimate dehydrogenase
5-dehydroquinate dehydratase
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5-dehydroquinate hydro-lyase
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bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplast
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dehydratase, 3-dehydroquinate
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dehydroquinate dehydratase
dehydroquinate dehydratase-shikimate dehydrogenase
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dehydroquinate synthase
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DHQ/SDH
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bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase
membrane-bound 3-dehydroquinate dehydratase
NtDHD/SHD-2
cytosolic isoenzyme
type I 3-dehydroquinate dehydratase
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type I dehydroquinate dehydratase
type II 3-dehydroquinate dehydratase
additional information
cf. EC 1.1.1.25
3-dehydroquinase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase
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3-dehydroquinate dehydratase/shikimate dehydrogenase
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3-dehydroquinate dehydratase/shikimate dehydrogenase
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aroD
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AroQ
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dehydroquinase
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dehydroquinate dehydratase
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dehydroquinate dehydratase
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dehydroquinate dehydratase
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dehydroquinate dehydratase
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dehydroquinate dehydratase
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DHQ2
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DHQase
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DHQD
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DQD
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EC 4.2.1.10
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mDQD
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membrane-bound 3-dehydroquinate dehydratase
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membrane-bound 3-dehydroquinate dehydratase
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MtDHQase
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pDQD
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periplasmic 3-dehydroquinate dehydratase
pDQD
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periplasmic 3-dehydroquinate dehydratase
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sDQD
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soluble, cytoplasmic 3-dehydroquinate dehydratase
sDQD
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soluble, cytoplasmic 3-dehydroquinate dehydratase
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Type I dehydroquinase
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Type I dehydroquinase
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Type I dehydroquinase
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type I dehydroquinate dehydratase
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type I dehydroquinate dehydratase
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type I dehydroquinate dehydratase
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type I dehydroquinate dehydratase
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type I dehydroquinate dehydratase
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type I DHQD
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type II 3-dehydroquinate dehydratase
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type II 3-dehydroquinate dehydratase
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Type II dehydroquinase
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Type II dehydroquinase
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Type II dehydroquinase
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Type II dehydroquinase
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Type II dehydroquinase
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Type II dehydroquinase
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Type II DHQase
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3-dehydroquinate = 3-dehydroshikimate + H2O
3-dehydroquinate = 3-dehydroshikimate + H2O
mechanism
3-dehydroquinate = 3-dehydroshikimate + H2O
the first step of the reaction involves the formation of an imine intermediate between the oxo group of the 3-dehydroquinate and the enzyme
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3-dehydroquinate = 3-dehydroshikimate + H2O
type I dehydroquinase catalyzes cis-dehydration of 3-dehydroquinate via a covalent imine intermediate
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3-dehydroquinate = 3-dehydroshikimate + H2O
type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate
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3-dehydroquinate = 3-dehydroshikimate + H2O
type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate
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3-dehydroquinate = 3-dehydroshikimate + H2O
type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate
3-dehydroquinate = 3-dehydroshikimate + H2O
type I and type II DHQases are quite distinct from one another in terms of amino acid sequences and three-dimensional structures. Type I enzymes involve a syn elimination and catalyse the biosynthetic reaction. By contrast type II enzymes, which can catalyse either the biosynthetic or catabolic reactions, involve and anti elimination reaction
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3-dehydroquinate = 3-dehydroshikimate + H2O
type I and type II DHQases have different biochemical and biophysical properties, and no sequence similarity exists between them
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3-dehydroquinate = 3-dehydroshikimate + H2O
DHQ2 catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid through anti elimination of water, with the loss of the more acidic pro-S hydrogen from C-2 of 3-dehydroquinate. The elimination proceeds by a stepwise E1CB mechanism involving an enol intermediate. In the first step, an essential tyrosine in the active site removes the pro-S hydrogen from C-2 of 1. The final step is the acid-catalyzed elimination of the C-1 hydroxy group, a reaction catalyzed by a histidine, which acts as a proton donor, reaction mechanism, overview
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3-dehydroquinate = 3-dehydroshikimate + H2O
DHQ2 catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid through anti elimination of water, with the loss of the more acidic pro-S hydrogen from C-2 of 3-dehydroquinate. The elimination proceeds by a stepwise E1CB mechanism involving an enol intermediate. In the first step, an essential tyrosine in the active site removes the pro-S hydrogen from C-2 of 1. The final step is the acid-catalyzed elimination of the C-1 hydroxy group, a reaction catalyzed by a histidine, which acts as a proton donor, reaction mechanism, overview
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3-dehydroquinate = 3-dehydroshikimate + H2O
DHQ2 catalyzes the reversible dehydration of 3-dehydroquinic acid to form 3-dehydroshikimic acid through anti elimination of water, with the loss of the more acidic pro-S hydrogen from C-2 of 3-dehydroquinate. The elimination proceeds by a stepwise E1CB mechanism involving an enol intermediate. In the first step, an essential tyrosine in the active site removes the pro-S hydrogen from C-2 of 1. The final step is the acid-catalyzed elimination of the C-1 hydroxy group, a reaction catalyzed by a histidine, which acts as a proton donor, reaction mechanism, overview
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3-dehydroquinate = 3-dehydroshikimate + H2O
type II dehydroquinase catalyzes a trans-dehydration via an enolate intermediate
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3-dehydroquinate = 3-dehydroshikimate + H2O
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(2R)-2-(4-methoxybenzyl)-3-dehydroquinic acid
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(2R)-2-methyl-3-dehydroquinic acid
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Substrates: compound is a reversible competive inhibitor of type 1 enzymes and a weak substrate of type 2 enzymes
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3-dehydroquinate
3-dehydroshikimate
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
3-deoxy-D-arabino-heptulosonate 7-phosphate
3-dehydroquinate + phosphate
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5-dehydroquinate
dehydroshikimate + H2O
dehydroquinate
dehydroshikimate + H2O
Substrates: -
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additional information
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(2R)-2-(4-methoxybenzyl)-3-dehydroquinic acid
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(2R)-2-(4-methoxybenzyl)-3-dehydroquinic acid
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
B7DR33
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3-dehydroquinate
3-dehydroshikimate + H2O
B7DR33
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
WP_011252021
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
WP_011252021
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
EMH96211.1
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3-dehydroquinate
3-dehydroshikimate + H2O
EMH96211.1
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
WP_003413001
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
WP_003413001
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
3-dehydroshikimate + H2O
Substrates: -
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3-dehydroquinate
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Substrates: the enzyme is involved in both the catabolism of quinate and the biosynthesis of aromatic amino acids
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3-dehydroquinate
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Substrates: type II dehydroquinase is involved in the quinate pathway
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3-dehydroquinate
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Substrates: type I dehydroquinase is involved in the biosynthetic shikimate pathway
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3-dehydroquinate
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Substrates: the enzyme catalyzes the third of the seven step shikimate pathway
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3-dehydroquinate
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Substrates: the enzyme catalyzes the third of the seven step shikimate pathway
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3-dehydroquinate
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Substrates: -
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3-dehydroquinate
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Substrates: the enzyme is likely to function in the shikimate pathway
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3-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme catalyzes the third step in the biosynthesis of chorismate
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5-dehydroquinate
?
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
?
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
?
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
?
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: -
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5-dehydroquinate
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Substrates: enzyme is involved in the biosynthesis of aromatic amino acids
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5-dehydroquinate
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Substrates: 2 isoenzymes: the catabolic dehydroquinase is produced by the qa-2 gene and the biosynthetic dehydroquinase is produced by the constitutive aro cluster
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Saccharomycopsis lipolytica
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
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Substrates: enzyme of the shikimate pathway
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5-dehydroquinate
dehydroshikimate + H2O
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Substrates: -
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5-dehydroquinate
dehydroshikimate + H2O