Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Homo sapiens and UniProt Accession Q16790

for references in articles please use BRENDA:EC4.2.1.1

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EC Tree 4 Lyases 4.2 Carbon-oxygen lyases 4.2.1 Hydro-lyases 4.2.1.1 carbonic anhydrase

The enzyme catalyses the reversible hydration of dissolved CO₂ to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn²⁺ is the most prevalent, but Cd²⁺, Co²⁺, Fe²⁺, and Mn²⁺ are also found .

The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms

Reaction Schemes

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Synonyms
carbonic anhydrase, ca ix, ca ii, hca ii, hca i, carbonic anhydrase ix, carbonic anhydrase ii, hca ix, ca iv, anhydrase, more

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Go to Synonym Search

alpha-CA

-

CA I

isozyme

CA II

isozyme

CA IX

show

CA9

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746925, 747699, 748307

carbonic anhydrase

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carbonic anhydrase 9

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carbonic anhydrase IX

-

664306, 698814, 706515, 747489, 748367

hCA IX

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664306, 678660, 678676, 678681, 678696, 678712, 746925, 747489, 747699, 748307

alpha-CA

show

alpha-carbonic anhydrase

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-

alpha-class carbonic anhydrase

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-

anhydrase

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-

-

-

bCA IV

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-

CA

show

CA I

show

CA II

show

CA III

show

CA IV

show

CA IX

show

CA VA

show

CA VB

show

CA VI

show

CA VII

show

CA VIII

-

CA XII

show

CA XIII

show

CA XIV

show

CA-I

show

CA-II

show

CA-III

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CA-IX

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-

-

-

CA-VA

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-

-

-

CA-VB

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-

-

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CA-VI

show

CA-VII

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-

-

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CA-XII

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-

-

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CA-XIV

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-

-

-

CA1

show

CA2

show

CA4

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CA5A

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CA9

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-

CAI

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-

CAII

show

CAIII

-

-

CAIX

show

carbonate anhydrase

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-

-

-

Carbonate dehydratase

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carbonate dehydratase III

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Carbonate dehydratase IX

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-

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Carbonate dehydratase VA

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-

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Carbonate dehydratase VB

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-

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Carbonate dehydratase VI

show

Carbonate dehydratase VII

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-

-

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Carbonate dehydratase XII

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-

-

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Carbonate dehydratase XIV

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-

-

-

carbonic acid anhydrase

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-

-

carbonic anhydrase

show

carbonic anhydrase 1

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carbonic anhydrase 14

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carbonic anhydrase 2

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746925, 748307, 748692

carbonic anhydrase 3

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carbonic anhydrase 5A

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carbonic anhydrase I

show

carbonic anhydrase I (CA I) Michigan 1

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carbonic anhydrase II

show

carbonic anhydrase III

show

carbonic anhydrase isozyme I

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652639, 652744, 652754

carbonic anhydrase isozyme II

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-

652639, 652744, 652754

carbonic anhydrase isozyme III

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carbonic anhydrase isozyme IV

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-

carbonic anhydrase isozyme IX

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-

carbonic anhydrase IV

show

carbonic anhydrase IX

show

carbonic anhydrase V

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carbonic anhydrase VA

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carbonic anhydrase VI

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carbonic anhydrase VII

show

carbonic anhydrase XII

show

carbonic anhydrase XIII

-

-

carbonic anhydrase XIV

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664306, 679413, 748270

carbonic anhydrase-I

show

carbonic anhydrase-II

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isozyme

carbonic anhydrase-related protein VIII

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carbonic dehydratase

show

carboxyanhydrase

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-

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CAVA

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CAXII

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isoform

dehydratase, carbonate

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-

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Gustin

formerly

H64A HCA II

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HC II

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-

HCA

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hCA I

show

HCA II

show

hCA III

show

hCA IV

show

hCA IX

-

-

hCA VA

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678676, 678681, 678696, 678712

hCA VB

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678676, 678681, 678696, 678712

hCA VI

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678676, 678681, 678696, 678712, 681312

hCA VII

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678676, 678681, 678696, 678712

hCA XII

show

hCA XIV

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678676, 678681, 678712

hCA XIV catalytic domain

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HCA-I

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HCA-II

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hCAII

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human carbonic anhydrase

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human carbonic anhydrase I

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human carbonic anhydrase II

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human carbonic anhydrase III

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human carbonic anhydrase isoenzyme I

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human carbonic anhydrase isoenzyme II

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human carbonic anhydrase IX

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human carbonic anhydrase XII

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human carbonic anhydrase XIV

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isozyme CA II

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isozyme CA IV

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Membrane antigen MN

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mesohalophilic carbonic anhydrase

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P54/58N

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pMW1

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poly-[Hb-SOD-CAT-CA]

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polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase

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RCC-associated antigen G250

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-

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Renal cell carcinoma-associated antigen G250

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-

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Salivary carbonic anhydrase

show

Secreted carbonic anhydrase

show

Tumor antigen HOM-RCC-3.1.3

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-

-

-

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Go to Reaction Search

H2CO3 = CO2 + H2O

show the reaction diagram

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elimination

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addition

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hydration

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dehydration

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Go to Pathway Search

BRENDA

cyanate degradation

KEGG

Nitrogen metabolism

MetaCyc

3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle, C4 photosynthetic carbon assimilation cycle, NAD-ME type, C4 photosynthetic carbon assimilation cycle, NADP-ME type, C4 photosynthetic carbon assimilation cycle, PEPCK type, CO2 fixation into oxaloacetate (anaplerotic), cyanate degradation, gluconeogenesis II (Methanobacterium thermoautotrophicum), glyoxylate assimilation

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carbonic acid hydro-lyase (carbon-dioxide-forming)

The enzyme catalyses the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn2+ is the most prevalent, but Cd2+, Co2+, Fe2+, and Mn2+ are also found [8].

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9001-03-0

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Go to Substrate/Product Search

CO2 + H2O

H2CO3

show the reaction diagram

show

H2CO3

CO2 + H2O

show the reaction diagram

show

2-nitrophenyl acetate + H2O

2-nitrophenol + acetate

show the reaction diagram

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Substrates: -
Products: -

?

3-nitrophenyl acetate + H2O

3-nitrophenol + acetate

show the reaction diagram

-

Substrates: -
Products: -

?

4-nitrophenyl acetate + H2O

4-nitrophenol + acetate

show the reaction diagram

show

4-nitrophenyl phosphate + H2O

4-nitrophenol + phosphate

show the reaction diagram

-

Substrates: -
Products: -

?

4-nitrophenyl propionate + H2O

4-nitrophenol + propionate

show the reaction diagram

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Substrates: -
Products: -

?

4-nitrophenyl sulfate + H2O

4-nitrophenol + sulfate

show the reaction diagram

-

Substrates: -
Products: -

?

CO2 + H2O

H2CO3

show the reaction diagram

show

H2CO3

CO2 + H2O

show the reaction diagram

show

additional information

?

-

show

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Go to Natural Substrate Search

CO2 + H2O

H2CO3

show the reaction diagram

O43570, Q16790, P00918, P00915

Substrates: -
Products: -

r

H2CO3

CO2 + H2O

show the reaction diagram

show

CO2 + H2O

H2CO3

show the reaction diagram

show

H2CO3

CO2 + H2O

show the reaction diagram

show

additional information

?

-

show

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Go to Metals and Ions Search

Co2+

strongly activating effect, Co2+ induces an increase in the kcat/Km value

Mg2+

strongly activating effect, Mg2+ induces an increase in the kcat/Km value

Mn2+

strongly activating effect, Mn2+ induces an increase in the kcat/Km value

Zn2+

show

Co2+

show

Cu2+

show

Na+

a key role for sodium ions in increasing halotolerant enzyme stability largely through interactions with the highly ordered first Na+ hydration shell, molecular dynamics calculations, overview. Very strong activation by Na2SO4 of all enzymes, especially of mutant M4, slight activation by NaCl, overview

Ni2+

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Zn2+

show

additional information

distribution of cations and anions within 3 A of the enzyme surface, overview

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Go to Inhibitor Search

(2E)-2-[(4-hydroxy-3-methylphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

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(2E)-2-[(4-hydroxyphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

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(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

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(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

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(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

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1,1,1-trifluoromethanesulfonamide

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1,1-dimethyl-4-(7-sulfamoyl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazol-3-yl)piperazin-1-ium iodide

-

2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

2-coumaric acid

Q16790, P00918, P00915

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2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

3-(4-methylpiperazin-1-yl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-(methylsulfonyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-(phenylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

3-[(anilinocarbonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4,5-dichloro-benzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX, i.e. daranide

4-(2-methylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-(3-formylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-(3-quinolinyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

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4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide

Q9ULX7, O43570, Q16790

-

4-aminoethylbenzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-phenylbenzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790

-

4-[(methylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[(phenylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

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4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

-

5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

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5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

-

6-chloro-4-amino-benzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

acetazolamide

show

brinzolamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

catechol

Q16790, P00918, P00915

-

curcumin

Q16790, P00918, P00915

-

dobutamine

Q16790, P00918, P00915

-

dorzolamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

ethoxzolamide

show

Furosemide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

H2NSO2NH2

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

H2NSO3H

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

homosulfanilamide

Q9ULX7, O43570, Q16790

-

hydrochlorothiazide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

methazolamide

-

methyl N-[(2,3,4,6-Tetra-O-acetyl-beta-D-glucosyl)sulfonyl]-L-4'-sulfamoylprolinate

-

methyl N-[(2,3,4,6-tetra-O-acetyl-beta-D-glucosyl)sulfonyl]-L-sulfamoylserinate

-

N-(1-(2-hydroxyphenylamino)-3-methyl-1-oxobutan-2-ylcarbamothioyl)benzamide

Q16790, P00918, P00915

i.e. NK-154, binding structure, overview

N-(1-(2-hydroxyphenylamino)-4-methyl-1-oxopentan-2-ylcarbamothioyl) benzamide

Q16790, P00918, P00915

i.e. NK-168, binding structure, overview

N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide

Q9ULX7, O43570, Q16790

-

N-2'-sulfamoylethyl-S-(2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-3'-R-sulfamoylpyrrolidinyl-S-(1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-3'-R-sulfamoylpyrrolidinyl-S-(2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-3'-sulfamoylpropyl-S-(1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-3'-sulfamoylpropyl-S-(2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-4'-sulfamoylpiperidinyl-S-(1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-4'-sulfamoylpiperidinyl-S-(2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-5'-sulfamoylpentyl-S-(1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-5'-sulfamoylpentyl-S-(2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosyl)sulfonamide

-

N-hydroxysulfamide

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]acetamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]benzamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]butanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]pentanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]propanamide

Q9ULX7, O43570, Q16790

-

N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

phenol

Q16790, P00918, P00915

-

propofol

Q16790, P00918, P00915

-

resorcinol

Q16790, P00918, P00915

-

resveratrol

Q16790, P00918, P00915

-

salicylic acid

Q16790, P00918, P00915

-

sulfanilamide

Q9ULX7, O43570, Q16790

-

sulthiame

Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

thioxolone

Q16790, P00918, P00915

-

topiramate

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

zonisamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

-

-

(2,4,6-triisopropylphenyl)sulfonylsulfamic acid

-

-

(2,4,6-tripropylphenyl)sulfonylsulfamic acid

-

-

(2,5-dichlorophenyl)sulfonylsulfamic acid

-

-

(2-nitrophenyl)sulfonylsulfamic acid

-

-

(2E)-2-[(4-hydroxy-3-methylphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

-

(2E)-2-[(4-hydroxyphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

-

(2E)-4-methoxy-4-oxobut-2-enoic acid

-

-

(2E)-but-2-enedioic acid

-

-

(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid

-

-

(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid

-

-

(3,5-dichloro-2-hydroxyphenyl)sulfonylsulfamic acid

-

-

(3-chloro-4-hydroxyphenyl)acetic acid

-

-

(3-chloro-4-nitrophenyl)sulfonylsulfamic acid

-

-

(3-chlorophenyl)acetic acid

-

-

(3-nitrophenyl)sulfonylsulfamic acid

-

-

(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate

-

-

(4-acetylphenyl)sulfonylsulfamic acid

-

-

(4-bromophenyl)sulfonylsulfamic acid

-

-

(4-chlorophenyl)sulfonylsulfamic acid

-

-

(4-fluorophenyl)sulfonylsulfamic acid

-

-

(4-hydroxyphenyl)acetic acid

-

-

(4-iodophenyl)sulfonylsulfamic acid

-

-

(4-methoxyphenyl)sulfonylsulfamic acid

-

-

(4-methylphenyl)sulfonylsulfamic acid

-

-

(4-nitrophenyl)sulfonylsulfamic acid

-

-

(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one

-

-

(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one

-

-

(E)-3-iodo-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

(heptadecafluorooctyl)sulfonylsulfamic acid

-

-

(nonafluorobutyl)sulfonylsulfamic acid

-

-

(pentafluorophenyl)sulfonylsulfamic acid

-

-

(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

-

(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

-

(S)-2-(2-ammoniopropanamido)-4-methylbenzo[d]thiazol-3-ium di-2,2,2-trifluoroacetate

O43570, P00918, P00915, P22748

-

(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

(S)-benzyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxopropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(S)-benzyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(S)-tert-butyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(S)-tert-butyl (1-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

-

(trichloromethyl)sulfonylsulfamic acid

-

-

(trifluoromethyl)sulfonylsulfamic acid

-

-

1,1,2,2,3,3,4,4 octafluoro-n-butane-1-4-bissulfonamide

-

-

1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-n-hexane-1-sulfonamide

-

-

1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-n-heptane-1-sulfonamide

-

-

1,2,4-trimethoxybenzene

-

-

1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane

-

-

1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)-ethoxy]ethane

-

-

1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane

-

-

1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane

-

-

1,2-dimethoxybenzene

-

-

1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate

-

-

1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate

-

-

1,3-bis(4-bromobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

1,3-dimethylpyrimidine-2,4(1H,3H)-dione

show

1,3-dioxolan-2-yl-N-(2-propenyl)-2-thiophene-sulfonamide

-

-

1,4-dimethoxybenzene

-

-

1-(1,2-benzoxazol-3-yl)methanesulfonamide

-

-

1-(3-cyanobenzyl)-3-(2,3,4,5,6-pentamethyl-benzyl)-3H-benzoimidazol-1-ium bromide

inhibitory to carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase

1-(3-cyanobenzyl)-3-(2,3,5,6-tetramethyl-benzyl)-3H-benzoimidazol-1-ium bromide

inhibitory to carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase

1-(3-cyanobenzyl)-3-(2,4,6-trimethyl-benzyl)-3H-benzoimidazol-1-ium bromide

inhibitory to carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase

1-(3-cyanobenzyl)-3-(2-methylbenzyl)-3H-benzoimidazol-1-ium bromide

inhibitory to carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase

1-(3-cyanobenzyl)-3-(4-methylbenzyl)-3H-benzoimidazol-1-ium bromide

inhibitory to carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase

1-(3-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

1-(4-chlorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol

ID-8

1-anilino-3-[(oxolan-2-yl)methoxy]propane-2-thiol

inhibits carbonic anhydrase, acetylcholinesterase and alpha-glycosidase

1-anilino-4,4,5,5-tetrafluoropentane-2-thiol

inhibits carbonic anhydrase, acetylcholinesterase and alpha-glycosidase

1-benzyl-3-(2,4,6-trimethoxybenzyl)-2-methylimidazolium chloride

-

1-benzyl-3-(N-methyphthalimide)-2-methylimidazolium bromide

-

1-benzyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

1-benzyl-3-[2-(4-hydroxyphenyl)ethyl]-2-methylimidazolium bromide

-

1-butyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

1-cyclopentyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

1-cyclopropyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

1-decyl-3-(2,4,6-trimethoxybenzyl)-2-methylimidazolium chloride

-

1-decyl-3-(N-methyphthalimide)-2-methylimidazolium bromide

-

1-decyl-3-[2-(4-hydroxyphenyl)ethyl]-2-methylimidazolium bromide

-

1-methoxy-3-(3-methylanilino)propane-2-thiol

inhibits carbonic anhydrase, acetylcholinesterase and alpha-glycosidase

1-n-butyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

1-naphthylsulfonylsulfamic acid

-

-

1-[(2-oxo-2H-chromen-6-yl)methyl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane

-

1-[2-(1H-imidazol-5-yl)ethyl]-4-methyl-2,6-di(propan-2-yl)pyridin-1-ium hexafluorophosphate

-

1H,1H,2H,2H-perfluorodecyl sulfamate

-

-

1H,1H,2H,2H-perfluorooctyl sulfamate

-

-

1H,1H-perfluoroethyl sulfamate

-

-

1H-perfluoroisopropyl sulfamate

-

-

2,2'-(1-(4-bromophenyl)ethane-1,1-diyl)bis(sulfanediyl)diacetic acid

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,2'-(1-(4-methoxyphenyl)ethane-1,1-diyl)bis(sulfanediyl)bis(N-(pyridin-2-yl)acetamide)

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,2'-(1-(4-methoxyphenyl)ethane-1,1-diyl)bis(sulfanediyl)diacetic acid

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,2'-(1-(4-nitrophenyl)ethane-1,1-diyl)bis(sulfanediyl)bis(N-(pyridin-2-yl)acetamide)

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,2'-(1-phenylethane-1,1-diyl)bis(sulfanediyl)bis(N-benzylacetamide)

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,2'-(1-phenylethane-1,1-diyl)bis(sulfanediyl)bis(N-p-tolylacetamide)

inhibits acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase

2,3,4,5,6-pentafluorobenzene-1-sulfonamide

VD10-9

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine

-

-

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine

-

-

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine

-

-

2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine

-

-

2,3,5,6-tetrafluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

VD10-35

2,3,5,6-tetrafluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

show

2,3,5,6-tetrafluoro-4-(morpholin-4-yl)benzene-1-sulfonamide

VD10-12

2,3,5,6-tetrafluoro-4-(phenylsulfanyl)benzene-1-sulfonamide

VD10-18

2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzene-1-sulfonamide

VD12-05

2,3,5,6-tetrafluoro-4-hydrazinylbenzene-1-sulfonamide

VD10-14

2,3,5,6-tetrafluoro-4-[(2-hydroxyethyl)sulfanyl]benzene-1-sulfonamide

VD10-13

2,3,5,6-tetrafluoro-4-[(2-phenylethyl)sulfanyl]benzene-1-sulfonamide

VD11-09

2,3,5-trifluoro-4-[(2-phenylethyl)sulfanyl]-6-[(propan-2-yl)amino]benzene-1-sulfonamide

VD11-71

2,3,5-trifluoro-6-(morpholin-4-yl)-4-[(2-phenylethyl)sulfanyl]benzene-1-sulfonamide

VD11-67

2,3,6-trifluoro-4-(2-hydroxyethanesulfonyl)-5-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]benzene-1-sulfonamide

-

2,3,6-trifluoro-5-[[(1R,2R)-2-hydroxy-1,2-diphenylethyl]amino]-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

VD11-39

2,4,6-trichlorophenyl sulfamate

-

-

2,4-bis(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

2,6-dimethoxybenzoic acid

-

-

2-((2,6-dichlorobenzyl)thio)-6-phenyl-5-(piperidin-1-ylmethyl) imidazo[2,1-b][1,3,4]-thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-((2,6-dichlorobenzyl)thio)-6-phenyl-5-(pyrrolidin-1-ylmethyl) imidazo[2,1-b][1,3,4]-thiadiazole

-

2-((2,6-dichlorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-((2,6-difluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-((2-chloro-6-fluorobenzyl)thio)-6-(3,4-dichlorophenyl)imidazo [2,1-b][1,3,4]thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

show

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

competitive. competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-methoxyphenyl)imidazo [2,1-b][1,3,4]thiadiazole

show

2-((2-chloro-6-fluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

2-(1-methylethyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(1-methylethyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

2-(2-methoxyethyl)-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(2-methoxyethyl)-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3,4-dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide

-

-

2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide

-

-

2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

-

-

2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide

-

-

2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide

-

-

2-(3-chloro-4-hydroxyphenyl)acetamide

-

-

2-(3-hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(3-hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3-hydroxypropyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(3-methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

show

2-(4-hydroxybenzylidene)-2H-indene-1,3-dione

-

-

2-(4-hydroxyphenyl)acetamide

-

-

2-(benzenesulfonamido-N-benzyl)-5-[N,Ndibenzylsulfonamido]-l,3,4-thiadiazole

-

-

2-(benzylamino)-3,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

VD10-39b

2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide

show

2-(p-toluenesulfonamido)-l,3,4-thiadiazole-5-sulfonamide

-

-

2-(phenylethynyl)benzenesulfonamide

-

-

2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate

-

-

2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide

-

-

2-aminobenzenesulfonamide

show

2-benzene-sulfonamido-l,3,4-thiadiazole-5-sulfonamide

-

-

2-chloro-3-[[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-18

2-chloro-3-[[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-12

2-chloro-3-[[(5-propylpyrimidin-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-14

2-chloro-4-[(phenylsulfanyl)acetyl]benzene-1-sulfonamide

E11-6

2-chloro-4-[2-[(prop-2-en-1-yl)amino]-1,3-thiazol-4-yl]benzene-1-sulfonamide

E11-64

2-coumaric acid

Q16790, P00918, P00915

-

2-cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-cyclopropylmethyl-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-ethyl-3-[[bis(2-hydroxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-hydrazinobenzenesulfonamide

show

2-hydroxycinnamic acid

-

-

2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-methanol 1,1-dioxide

-

-

2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide

-

-

2-methyl-3-(4-morpholinylmethyl)-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

2-methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-methyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-methyl-3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-methyl-3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)-amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide

show

2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Met

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp

-

-

2-N-(4-sulfamoylphenyl)-thioformyl-L-Val

-

-

2-naphthyl sulfamate

-

-

2-naphthylsulfamate

-

-

2-naphthylsulfonylsulfamic acid

-

-

2-nitrobenzenesulfonamide

-

-

2-Nitrophenol

-

product inhibition

2-oxo-2H-chromene-3-carboxylic acid

-

2-oxo-2H-thiochromene-3-carboxylic acid

-

2-phenylethyl sulfamate

-

-

2-propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-[(4-morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

2-[(ethylsulfanyl)(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]malononitrile

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

2-[(p-toluenesulfonamido)-N-methyl]-5-[N,N-dimethylsulfonamide]-l,3,4-thiadiazole

-

-

2-[2-(4-morpholinyl)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride

-

-

2-[2-(acetoxy)ethyl]-N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

2-[2-(propylamino)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride

-

-

2-[2-[4-acetyl-(1-piperazinyl)]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

2-[2-[bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride

-

-

2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride

-

-

2-[benzenesulfonamido-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide

-

-

2-[[(3,4-dimethoxyphenyl)methyl]amino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzene-1-sulfonamide

VD12-17

2-[[(3,4-dimethoxyphenyl)methyl]amino]-3,5,6-trifluoro-4-[(2-phenylethyl)sulfanyl]benzene-1-sulfonamide

VD12-04

2H-chromen-2-one

-

3,3,4,4,5,5,6,6,6-nonafluoro-n-hexanesulfonamide

-

-

3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-n-octanesulfonamide

-

-

3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-n-decanesulfonamide

-

-

3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine

-

-

3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine

-

-

3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

3,4-dihydroxybenzoic acid

-

-

3,4-dimethoxybenzoic acid

-

-

3,5-dibromo-2-(1,3-dioxalan-2-yl)-thiophene

-

-

3,5-Dihydroxybenzoic acid

-

-

3-(1,3-dioxolan-2-yl)-N-(2-methoxyethyl)-2-thiophenesulfonamide

-

-

3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide

-

-

3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide

-

-

3-(1,3-dioxolan-2-yl)-N-(4-(4-morpholinyl)phenyl)-2-thiophenesulfonamide

-

-

3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide

-

-

3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide

-

-

3-(benzylamino)-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

-

3-(benzylamino)-2,5,6-trifluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

VD11-28

3-(cyclooctylamino)-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

VD11-4-2

3-(phenylethynyl)benzenesulfonamide

-

-

3-3-(1,3-dioxolan-2-yl)-N-(1-methylethyl)-2-thiophene-sulfonamide

-

-

3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

3-chloropropyl sulfamate

-

-

3-Hydroxybenzoic acid

-

-

3-hydroxymethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

3-hydroxymethyl-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

3-imino-1-ethylsulfanyl-5,6,7,8-tetrahydro-3H-pyrrolo[1,2-a]indole-2-carboxamide

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

3-iodo-1-(prop-2-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

3-iodo-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

3-iodo-1-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

3-methylphenylsulfamate

-

-

3-methylsalicylic acid

-

noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II

3-phenylprop-2-ene-1-sulfonamide

-

-

3-phenylpropanenitrile

-

-

3-tributylgermylpropanamine

-

-

3-triethylgermylpropanamine

-

-

3-triethylsilylpropanamine

-

-

3-triphenylgermylpropanamine

-

-

3-[(1-imidazolyl)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

3-[(1H-benzimidazol-1-yl)acetyl]-2-chlorobenzene-1-sulfonamide

E11-36

3-[(1H-benzimidazol-1-yl)acetyl]benzene-1-sulfonamide

E11-37

3-[(2,3,5,6-tetrafluoro-4-sulfamoylphenyl)sulfanyl]propanoic acid

VD11-56

3-[(2,3-dihydro-1H-inden-2-yl)amino]-2,5,6-trifluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

VD11-16

3-[(2-benzyl-1H-benzimidazol-1-yl)acetyl]-2-chlorobenzene-1-sulfonamide

E11-52

3-[(2-benzyl-1H-benzimidazol-1-yl)acetyl]benzene-1-sulfonamide

E11-53

3-[(3-fluorophenyl)ethynyl]benzenesulfonamide

-

-

3-[(3-methoxyphenyl)ethynyl]benzenesulfonamide

-

-

3-[(4-methylphenyl)ethynyl]benzenesulfonamide

-

-

3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

3-[(4-morpholinyl)methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

3-[(adamantan-2-yl)amino]-2,5,6-trifluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

VD11-17

3-[(anilinocarbonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

3-[(cyclopropylamino)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

3-[(sulfoamino)sulfonyl]benzoic acid

-

-

3-[1,3-dioxolan-2-yl]-N-(2-methoxyethyl)-2-thiophenesulfonamide

-

-

3-[1,3-dioxolan-2-yl]-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide

-

-

3-[9-borabicyclo[1.3.3.]nonane]-1-bromopropane

-

-

3-[9-borabicyclo[1.3.3.]nonane]-1-propylsulfonic acid sodium salt

-

-

3-[[(1,3-benzothiazol-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-57

3-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

-

3-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-2,5,6-trifluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide

-

3-[[(3,4-dimethoxyphenyl)methyl]amino]-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide

-

3-[[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-11

3-[[(5-propylpyrimidin-2-yl)sulfanyl]acetyl]benzene-1-sulfonamide

E11-15

3-[[(aminosulfonyl)amino]sulfonyl]benzoic acid

-

-

3-[[bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride

-

-

3-[[N-(2-methoxyethyl)-N-methylamino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

3alpha,12alpha-diacetoxy-5beta-cholan-24-oic acid

-

-

3alpha,7alpha,12alpha-triacetoxy-5beta-cholan-24-oic acid

-

-

3alpha-acetoxy-5beta-cholan-24-oic acid

-

-

4,4'-thiodipyridine-3-sulfonamide

-

-

4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)

-

-

4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)

-

-

4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)

-

-

4,5-dichloro-benzene-1,3-disulfonamide

show

4,5-dichlorobenzene-1,3-disulfonamide

-

-

4,6-dinitrosalicylic acid

-

noncompetitive inhibition of isozymes carbonic anhydrase I and II

4-((2-((2,6-dichlorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazol-5-yl)methyl)-morpholine

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

4-((2-((2,6-difluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazol-5-yl)methyl)-morpholine

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

4-((2-((2-chloro-6-fluorobenzyl)thio)-6-phenylimidazo[2,1-b] [1,3,4]thiadiazol-5-yl)methyl)morpholine

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

4-(1,3,4-thiadiazol-2-ylthio)pyridine-3-sulfonamide

-

-

4-(1-methyl-5-tetrazolylthio)pyridine-3-sulfonamide

-

-

4-(1-[2-[2-(3-bromobenzylidene)hydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[(3-bromophenyl)methylene]benzohydrazide

-

-

4-(1-[2-[2-(4-bromo-2-hydroxybenzylidene)hydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[(4-bromo-2-ydroxyphenyl)methylene]benzohydrazide

-

-

4-(1-[2-[2-(4-bromobenzylidene)hydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[(4-bromophenyl)methylene]benzohydrazide

-

-

4-(1-[2-[2-(4-chlorobenzylidene)hydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[(4-chlorophenyl)methylene]benzohydrazide

-

-

4-(1-[2-[2-(4-methoxybenzylidene)hydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[(4-methoxyphenyl)methylene]benzohydrazide

-

-

4-(1-[2-[2-benzylidenehydrazino]-2-oxoethyl]-3-methyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)-N'-[phenylmethylene]benzohydrazide

-

-

4-(2-((2-chloro-6-fluorobenzyl)thio)imidazo[2,1-b][1,3,4] thiadiazol-6-yl)benzonitrile

show

4-(2-aminoethyl)benzenesulfonamide

show

4-(2-hydroxyethyl)benzenesulfonamide

show

4-(2-hydroxyethyl)phenol

-

-

4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide

-

-

4-(2-methylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-(2-phenylacetamido)-3-bromobenzenesulfonamide

show

4-(2-phenylacetamido)-3-chlorobenzenesulfonamide

show

4-(2-phenylacetamido)-3-fluorobenzenesulfonamide

show

4-(2-phenylacetamido)benzenesulfonamide

show

4-(2-phenylacetamidoethyl)benzenesulfonamide

show

4-(2-phenylacetamidomethyl)benzenesulfonamide

show

4-(2-propynylthio)pyridine-3-sulfonamide

-

-

4-(2-pyridin-2-ylacetamido)benzenesulfonamide

show

4-(2-pyridin-4-ylacetamido)benzenesulfonamide

show

4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide

show

4-(3-formylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-(3-quinolinyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide

-

-

4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide

-

-

4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide

-

-

4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide

-

-

4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide

-

-

4-(4-cyanophenoxy)-3-pyridinesulfonamide

-

-

4-(4-fluorophenoxy)-3-pyridinesulfonamide

-

-

4-(4-hydroxyphenyl)-2-(3-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-(4-bromophenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-(4-chlorophenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-(4-fluorophenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-(4-methoxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-p-tolyl-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(4-hydroxyphenyl)-2-phenyl-5H-indeno[1,2-b]pyridin-5-one

-

-

4-(5-methyl-2-pyrazolino)-3-pyridinesulfonamide

-

-

4-(6-nitrobenzothiazol-2-ylthio)pyridine-3-sulfonamide

-

-

4-(allylamino)-3-pyridinesulfonamide

-

-

4-(aminomethyl)benzenesulfonamide

show

4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide

Q9ULX7, O43570, Q16790

-

4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide

-

4-(aminosulfonyl)benzoic acid

show

4-(benzenesulfonyl)-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD11-51

4-(benzylamino)-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD10-16

4-(benzylsulfanyl)-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD11-61

4-(carbamoylmethylthio)pyridine-3-sulfonamide

-

-

4-(cyanomethylthio)pyridine-3-sulfonamide

-

-

4-(hydroxymethyl)benzenesulfonamide

show

4-(methylhydrazino)-3-pyridinesulfonamide

-

-

4-(N-oxide-2-pyridylthio)pyridine-3-sulfonamide

-

-

4-(phenylethynyl)benzenesulfonamide

-

-

4-(propylsulfanyl)benzene-1-sulfonamide

VD12-10

4-(quinolinoxy)-3-pyridinesulfonamide

-

-

4-acetyl-N-(aminosulfonyl)benzenesulfonamide

-

-

4-acetylamidophenyl sulfamate

-

-

4-amino-3,5-dibromobenzenesulfonamide

-

4-amino-3-bromobenzenesulfonamide

-

4-amino-3-chlorobenzenesulfonamide

show

4-amino-3-fluoro-5-iodobenzenesulfonamide

-

4-amino-3-fluorobenzenesulfonamide

show

4-amino-3-iodobenzenesulfonamide

-

4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide

show

4-amino-6-chlorobenzene-1,3-disulfonamide

show

4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide

show

4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide

show

4-Aminobenzenesulfonamide

show

4-aminoethylbenzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-aminosalicylic acid

-

noncompetitive inhibition of isozymes carbonic anhydrase I and II

4-benzyl-6-(thiophen-2-yl)pyrimidin-2-amine

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

4-benzythiopyridine-3-sulfonamide

-

-

4-bromo-5-(1,3-dioxalan-2-yl)-N-(1,1-dimethylethyl)-thiophene-2-sulfonamide

-

-

4-bromobenzenesulfonamide

-

-

4-bromophenyl sulfamate

-

-

4-chlorobenzenesulfonamide

-

-

4-chlorophenyl sulfamate

-

best CA IX inhibitor

4-cyanophenyl sulfamate

-

-

4-ethoxy-3-pyridinesulfonamide

-

-

4-ethynylbenzenesulfonamide

-

-

4-fluorobenzenesulfonamide

-

4-hydrazino-3-pyridinesulfonamide

-

-

4-hydrazinobenzenesulfonamide

-

4-hydroxybenzenesulfonamide

-

-

4-iodobenzenesulfonamide

-

-

4-iodophenyl sulfamate

-

-

4-methoxy-3-pyridinesulfonamide

-

-

4-methoxyphenyl sulfamate

-

-

4-methylbenzenesulfonamide

show

4-methylphenyl sulfamate

-

-

4-methylthiopyridine-3-sulfonamide

-

-

4-nitrobenzenesulfonamide

-

-

4-nitrophenyl sulfamate

-

-

4-phenoxyphenyl sulfamate

-

-

4-phenylbenzene-1-sulfonamide

O43570, Q16790, P00918, P00915

-

4-phenylphenyl sulfamate

-

-

4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

-

binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I

4-sulfosalicylic acid

-

uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II

4-t-butylphenyl sulfamate

-

-

4-toluenesulfonamide

-

-

4-trichloromethylphenyl sulfamate

-

-

4-[(1,3-benzothiazol-2-yl)sulfanyl]-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD10-49

4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide

show

4-[(2-hydroxyethyl)sulfanyl]benzene-1-sulfonamide

VD11-31

4-[(2-phenylethyl)sulfanyl]benzene-1-sulfonamide

VD11-36

4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

-

4-[(3-fluorophenyl)ethynyl]benzenesulfonamide

-

-

4-[(3-hydroxyphenyl)ethynyl]benzenesulfonamide

-

-

4-[(3-methoxyphenyl)ethynyl]benzenesulfonamide

-

-

4-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD10-45

4-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-2,3,5,6-tetrafluorobenzene-1-sulfonamide

VD10-50

4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-2-methoxyphenyl methanesulfonate

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]phenylmethanesulfonate

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

4-[(4-methylphenyl)ethynyl]benzenesulfonamide

-

-

4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790

-

4-[(methylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[(phenylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[(sulfoamino)sulfonyl]benzoic acid

-

-

4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide

show

4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide

show

4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide

show

4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide

show

4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide

show

4-[2-(2-thienyl)acetamido]benzenesulfonamide

show

4-[2-(4-sulfamoylphenyl)ethylamino]-3-pyridinosulfonamide

-

-

4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole

-

-

4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole

-

-

4-[4-(methylsulfonyl)phenyl]-3-phenyldihydrofuran-2(3H)-one

-

-

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

-

-

4-[N'-(1,1-dioxopyrido[4,3-e]-1,4,2-dithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

-

-

4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

-

-

4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

-

-

4-[[(aminosulfonyl)amino]sulfonyl]benzoic acid

-

-

4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

-

5,6-diamino-1,3-dimethyluracil

show

5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide

show

5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide

show

5-(3,7,12-trioxo-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(3alpha,12alpha-dihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(3alpha,7alpha,12alpha-triacetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(3alpha-acetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(3alpha-hydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide

-

-

5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

show

5-acetamido-1,3,4-thiadiazole-2-sulfonamide

show

5-amino-1,3,4-thiadiazole-2-sulfonamide

show

5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione

show

5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione

show

5-chlorosalicylic acid

-

uncompetitive inhibition of isozymes carbonic anhydrase I and II

5-fluorouracil

show

5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide

show

5-pentylresorcinylsulfamate

-

-

5-sulfosalicylic acid

-

competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II

5-[(2-phenylethyl)(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(2,4-dichlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(2-methylpropyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(3,4,5-trimethoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(4-chlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(4-methoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(butyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(dodecyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(pentyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[(benzylsulfonyl)(propan-2-yl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide

show

5-[benzyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[ethyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[methyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide

-

-

5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

-

5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

-

5-{(2,4-dichlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(4-bromobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(4-chlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(4-fluorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(4-methoxybenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(4-methylbenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{(benzylsulfonyl)[2-(4-bromophenyl)ethyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{benzyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{butyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{dodecyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{ethyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{methyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

show

5-{[(4-methylphenyl)sulfonyl](2-methylpropyl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-methylphenyl)sulfonyl](2-phenylethyl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-methylphenyl)sulfonyl](3,4,5-trimethoxybenzyl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-methylphenyl)sulfonyl](pentyl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-methylphenyl)sulfonyl](propan-2-yl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[(4-methylphenyl)sulfonyl](propyl)amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[2-(4-bromophenyl)ethyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

5-{[3-(2-methoxyphenyl)propyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide

-

-

6,7-dimethoxy-1-ethyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

6,7-dimethoxy-1-isopropyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

6,7-dimethoxy-1-propyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

-

6-((1S)-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one

-

6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one

-

-

6-(4-bromophenyl)-2-((2-chloro-6-fluorobenzyl)thio)imidazo[2,1-b][1,3,4]thiadiazole

show

6-(aminomethyl)-2H-chromen-2-one

-

6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid

-

6-(hydroxymethyl)-2H-chromen-2-one

-

6-([1,1'-biphenyl]-4-yl)-2-((2-chloro-6-fluorobenzyl)thio)imidazo [2,1-b][1,3,4]thiadiazole

competitive. Potent acetylcholinesterase and non-classical carbonic anhydrase inhibitor

6-acetyl-7-(benzyloxy)-2H-chromen-2-one

-

-

6-acetyl-7-adamantylethoxy-2H-chromen-2-one

-

-

6-acetyl-7-butoxy-2H-chromen-2-one

-

-

6-acetyl-7-ethoxy-2H-chromen-2-one

-

-

6-acetyl-7-hydroxy-2H-chromen-2-one

-

-

6-acetyl-7-methoxy-2H-chromen-2-one

-

-

6-acetyl-7-propoxy-2H-chromen-2-one

-

-

6-amino-1,3-dimethyluracil

show

6-amino-5-bromouracil

-

6-amino-5-chlorouracil

-

6-chloro-4-amino-benzene-1,3-disulfonamide

show

6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine

-

-

6-ethoxy-1,3-benzothiazole-2-sulfonamide

-

-

6-hydroxy-1,3-benzothiazole-2-sulfonamide

-

6-methoxy-2-oxo-2H-chromene-3-carboxylic acid

-

6-methyl-2-oxo-2H-chromene-3-carboxylic acid

-

6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

show

6-methylpyrimidine-2,4(1H,3H)-dione

show

6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide

show

667-coumate

-

7-(2-phenylethoxy)-2H-chromen-2-one

-

7-(benzyloxy)-2H-chromen-2-one

-

7-alpha-hydroxydehydroepiandrosterone sulfamate

-

-

7-butoxy-2H-chromen-2-one

-

7-ethoxy-2H-chromen-2-one

-

7-ethoxy-8-propanoyl-2H-chromen-2-one

-

-

7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid

-

-

7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid

-

-

7-hydroxy-6-propanoyl-2H-chromen-2-one

-

-

7-hydroxy-8-propanoyl-2H-chromen-2-one

-

-

7-methoxy-2-oxo-2H-chromene-4-carboxylic acid

-

7-methoxy-2H-chromen-2-one

-

7-methoxy-8-propanoyl-2H-chromen-2-one

-

-

7-oxodehydroepiandrosterone sulfamate

-

-

7-propoxy-2H-chromen-2-one

-

7alpha-hydroxyepiandrosterone sulfamate

-

-

8-acetyl-7-(benzyloxy)-2H-chromen-2-one

-

-

8-acetyl-7-butoxy-2H-chromen-2-one

-

-

8-acetyl-7-ethoxy-2H-chromen-2-one

-

-

8-acetyl-7-hydroxy-2H-chromen-2-one

-

-

8-acetyl-7-methoxy-2H-chromen-2-one

-

-

8-acetyl-7-propoxy-2H-chromen-2-one

-

-

8-methoxy-2-oxo-2H-chromene-3-carboxylic acid

-

8-propanoyl-7-propoxy-2H-chromen-2-one

-

-

acetaldehyde

-

modification of carbonic anhydrase II with acetaldehyde leads to decreased enzyme activity, acetaldehyde (100 mM) in the presence of NaBH3(CN) causes 23.7% reduction in CA II activity, in the absence of NaBH3(CN) the activity is only slightly reduced

acetazolamide

show

Acetylsalicylic acid

-

noncompetitive inhibition of isozymes carbonic anhydrase I and II

allylamine hydrochloride

-

-

allylsulfonamide

-

-

allylsulfonamide hydrochloride

-

-

allylsulfonyl chloride

-

-

amikacin sulfate

noncompetitive inhibition

amoxicillin

uncompetitive inhibition

ampicillin

uncompetitive inhibition

ArSO2-NHPO3H2

-

-

azetazolamide

-

-

azide

best inhibitor

Benzene

-

benzene-1,2-diol

inhibition of isozyme hCA I

benzene-1,3-diol

inhibition of isozyme hCA I

benzenesulfonamide

-

-

benzolamide

show

Benzyl (2-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-2-oxoethyl)carbamate

O43570, P00918, P00915, P22748

-

benzyl (2-((4-methylbenzo[d]thiazol-2-yl)amino)-2-oxoethyl)carbamate

O43570, P00918, P00915, P22748

-

benzyl (2-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)carbamate

O43570, P00918, P00915, P22748

-

benzyl sulfamate

-

-

benzylsulfonylsulfamic acid

-

-

bicarbonate

show

brinzolamide

show

bromide

-

but-3-enyl sulfamate

-

-

but-3-ynyl sulfamate

-

-

callistephin

-

Carbonate

best inhibitor

catechin

-

a competitive inhibitor with 4-nitrophenylacetate as substrate

catechol

show

cefazolin

uncompetitive inhibition

cefoperazone

uncompetitive inhibition

ceftriaxone

noncompetitive inhibition

cefuroxime

uncompetitive inhibition

celecoxib

show

CF3SO2NH2

-

-

chlorazolamide

-

-

chloride

-

Chlorthalidone

chlorthalidone is a medium potency CA I, II, and IV inhibitor, a very effective inhibitor of CA VB, CA VII, CA IX, CA XII, and CA XIII and an ineffective inhibitor of isozymes CA III, VA, VI, and XIV

chlorzolamide

potent inhibitor

cholesteryl sulfamate

-

-

Cl-

-

relatively resistant to

clindamycin phosphate

uncompetitive inhibition

-

coumarin

-

-

702687, 714459, 714423

Cu-GGHSLN

time-dependent inactivation of carbonic anhydrase I activity, within 3 h carbonic anhydrase I activity is eliminated at 0.005 mM Cu-GGHSLN

-

curcumin

show

cyanamide

-

-

Cyanate

-

-

649577, 652546, 651596

cyanide

best inhibitor

cyclohexyl sulfamate

-

-

cyclopentyl sulfamate

-

-

D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-alloisoleucinamide

-

-

D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-leucinamide

-

-

D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-phenylalaninamide

-

-

dehydroepiandrosterone sulfamate

show

dichlorophenamide

show

diflunisal

-

noncompetitive inhibition of isozymes carbonic anhydrase I and II

dimethylsilyl para-toluenesulfonamidoborane

-

-

dimethylsilyl-diphenylaminoborane

-

-

dimethylsilyl-N-methyl-N-phenylaminoborane

-

-

dimethylsilylaminoborane

-

-

dimethylsilylboronic acid

-

-

dimethylsilylfluoroborane

-

-

dimethylsilylsulfonamidoborane

-

-

dinitrosalicylic acid

-

-

dobutamin

show

dorzolamide

show

EMATE

-

-

EMD 486019

EMD 486019 acts as a strong inhibitor of isozymes carbonic anhydrase II, VB, VII, IX, XII, and XIV

estradiol 17 beta-sulfamate

-

-

estradiol 3,17 beta-disulfamate

show

estrone sulfamate

-

-

ethanol

-

-

ethoxazolamide

-

systemic carbonic anhydrase inhibitor

ethoxyzolamide

-

-

ethoxzolamide

show

ethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate 1,1-dioxide

-

-

ethyl 2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide

-

-

ethyl 2-[[2-(4-chloro-3-sulfamoylphenyl)-2-oxoethyl]sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylate

E46

ethyl 3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide

-

-

ethyl 5-phenyl-1H-pyrrole-2-carbodithioate

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

-

ethyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate

-

ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate

-

ethyl sulfamate

-

-

fluorenylmethyl sulfamate

-

-

fluoride

weak inhibitor

Furosemide

show

gentamicin sulfate

uncompetitive inhibition

H2NSO2NH2

show

H2NSO3H

show

histamine

-

-

homosulfanilamide

Q9ULX7, O43570, Q16790

-

hydrochlorothiazide

show

hydrogen sulfide

best inhibitor

hydrosulfide

-

Hydroxyurea

-

-

I-

show

indapamide

indapamide is a quite ineffective inhibitor of isozymes CA I, II, III, VA, VI, and XIV, a medium potency CA IV and CA VB inhibitor, and a very effective inhibitor of isozymes CA VII, IX, XII, and XIII

indisulam

show

Isoorotic acid

show

isopropyl sulfamate

-

-

isopropylsulfonylsulfamic acid

-

-

kanamycin sulfate

competitive inhibition

L-adrenaline

-

-

Lincomycin

competitive inhibition

malvin

-

melphalan

-

-

methazolamide

show

methyl (3-chloro-4-hydroxyphenyl)acetate

-

-

methyl 2-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-3-nitrobenzoate

inhibitor of acetylcholinesterase and the human carbonic anhydrase isoforms I and II

methyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate

-

methyl sulfamate

-

-

methylbenzolamide

-

-

methylsulfonylsulfamic acid

-

-

N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2,3-dihydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2,4,6-trihydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-Bis[(E)-(2,4-dichlorophenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2,5-dihydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2,6-dichlorophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(2-bromophenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-chloro-5-nitrophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(2-chlorophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(2-fluorophenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-hydroxy-5-methoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-hydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-methoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(2-nitrophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(3,4-dimethoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(3-ethoxy-2-hydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(3-hydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(3-methoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(4-bromophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(4-chlorophenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(4-fluorophenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(4-hydroxyphenyl)methylidene]carbonic dihydrazide

-

-

N'',N'''-bis[(E)-(4-methoxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-(4-nitrophenyl)methylidene]carbonic dihydrazide

mixed-type inhibition

N'',N'''-bis[(E)-(5-bromo-2-hydroxyphenyl)methylidene]carbonic dihydrazide

-

N'',N'''-bis[(E)-phenylmethylidene]carbonic dihydrazide

-

N'-[(1Z)-1-(5-chlorothiophen-3-yl)ethylidene]butane-1-sulfonohydrazide

good inhibitor of alpha-glycosidase, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme

N'-[(1Z)-1-(furan-3-yl)ethylidene]butane-1-sulfonohydrazide

good inhibitor of alpha-glycosidase, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme

N'-[(1Z)-1-(thiophen-3-yl)ethylidene]butane-1-sulfonohydrazide

good inhibitor of alpha-glycosidase, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme

N'-[(Z)-(1H-indol-3-yl)methylidene]butane-1-sulfonohydrazide

good inhibitor of alpha-glycosidase, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme

N,N'-biphosphoryl-4,5-dichloro-1,3-benzenesulfonamide

-

-

N,N'-bis(benzylsulfonyl)allylamine

-

-

N,N'-bis(styrenesulfonyl)allylamine

-

-

N,N-dimethylamidimidodisulfuric acid

-

-

N,N-dimethylimidodisulfuric diamide

-

-

N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(2-propylaminol)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide

-

-

N-(1,1-dimethylethyl)-2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide

-

-

N-(1-(2-hydroxyphenylamino)-3-methyl-1-oxobutan-2-ylcarbamothioyl)benzamide

Q16790, P00918, P00915

i.e. NK-154, binding structure, overview

N-(1-(2-hydroxyphenylamino)-4-methyl-1-oxopentan-2-ylcarbamothioyl) benzamide

Q16790, P00918, P00915

i.e. NK-168, binding structure, overview

N-(2-fluoro-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide

-

-

N-(4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide

-

-

N-(4-[(E)-[(aminosulfonyl)imino]methyl]phenyl)acetamide

-

-

N-(4-[[(aminosulfonyl)amino]sulfonyl]phenyl)acetamide

-

-

N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide

-

-

N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

-

-

N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide

Q9ULX7, O43570, Q16790

-

N-(allylsulfonyl)allylamine

-

-

N-(allysulfonyl)-3-triethylsilylpropanamine

-

-

N-(aminosulfonyl)-1,1,1-trichloromethanesulfonamide

-

-

N-(aminosulfonyl)-1,1,1-trifluoromethanesulfonamide

-

-

N-(aminosulfonyl)-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide

-

-

N-(aminosulfonyl)-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide

-

-

N-(aminosulfonyl)-1-(7,7-dimethylbicyclo[2.2.1]hept-1-yl)methanesulfonamide

-

-

N-(aminosulfonyl)-1-phenylmethanesulfonamide

-

-

N-(aminosulfonyl)-2,3,4,5,6-pentafluorobenzenesulfonamide

-

-

N-(aminosulfonyl)-2,4,6-triisopropylbenzenesulfonamide

-

-

N-(aminosulfonyl)-2,4,6-tripropylbenzenesulfonamide

-

-

N-(aminosulfonyl)-2,5-dichlorobenzenesulfonamide

-

-

N-(aminosulfonyl)-2-nitrobenzenesulfonamide

-

-

N-(aminosulfonyl)-3,5-dichloro-2-hydroxybenzenesulfonamide

-

-

N-(aminosulfonyl)-3-(trifluoromethyl)benzenesulfonamide

-

-

N-(aminosulfonyl)-3-chloro-4-nitrobenzenesulfonamide

-

-

N-(aminosulfonyl)-3-nitrobenzenesulfonamide

-

-

N-(aminosulfonyl)-4-bromobenzenesulfonamide

-

-

N-(aminosulfonyl)-4-chlorobenzenesulfonamide

-

-

N-(aminosulfonyl)-4-fluorobenzenesulfonamide

-

-

N-(aminosulfonyl)-4-iodobenzenesulfonamide

-

-

N-(aminosulfonyl)-4-methoxybenzenesulfonamide

-

-

N-(aminosulfonyl)-4-methylbenzenesulfonamide

-

-

N-(aminosulfonyl)-4-nitrobenzenesulfonamide

-

-

N-(aminosulfonyl)-5-(dimethylamino)naphthalene-1-sulfonamide

-

-

N-(aminosulfonyl)benzenesulfonamide

-

-

N-(aminosulfonyl)methanesulfonamide

-

-

N-(aminosulfonyl)naphthalene-1-sulfonamide

-

-

N-(aminosulfonyl)naphthalene-2-sulfonamide

-

-

N-(aminosulfonyl)propane-2-sulfonamide

-

-

N-(aminosulfonyl)quinoline-8-sulfonamide

-

-

N-(aminosulfonyl)thiophene-2-sulfonamide

-

-

N-(benzylsulfonyl)-3-tributylgermylpropanamine

-

-

N-(benzylsulfonyl)-3-triethylsilylpropanamine

-

-

N-(benzylsulfonyl)allylamine

-

-

N-(cyclopropylmethyl)-3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide

-

-

N-(dimesilylboro)allylsulfonamide

-

-

N-(styrenesulfonyl)-3-triethylsilylpropanamine

-

-

N-(tert-butoxycarbonyl)-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-alloisoleucinamide

-

-

N-(tert-butoxycarbonyl)-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-leucinamide

-

-

N-(tert-butoxycarbonyl)-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

N-(tert-butoxycarbonyl)-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-phenylalaninamide

-

-

N-(tert-butoxycarbonyl)-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide

-

-

N-(trans-styrenesulfonyl)allylamine

-

-

N-4-methoxyphenylsulfonyl-N-2-nitrobenzyl-L-alanine hydroxamate

-

-

N-4-methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate

-

-

N-allyl-1-phenylmethanesulfonamide

-

-

N-allylsulfonyl-3-[9-borabicyclo[1.3.3.]nonane]propanamine

-

-

N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide

-

-

n-butyl sulfamate

-

-

N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide

-

-

N-cyclohexyl-N-[(3-formyl-thien-2-yl)sulfonyl]-glycine methyl ester

-

-

N-cyclopropylmethyl-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide

-

-

n-decyl sulfamate

show

n-dodecyl sulfamate

-

-

n-hexadecyl sulfamate

-

-

n-hexanesulfonamide

-

-

N-hydroxysulfamide

show

N-hydroxysulfonamide

-

-

N-n-perfluorobutylsulfonyl-alanine hydroxamate

-

-

n-octadecyl sulfamate

-

-

n-octanesulfonamide

-

-

n-octyl sulfamate

show

N-pentafluorophenylsulfonyl-glycine

-

-

N-pentafluorophenylsulfonyl-glycine hydroxamate

-

-

N-pentafluorophenylsulfonyl-N-4-nitrobenzyl-glycine hydroxamate

-

-

n-pentyl sulfamate

-

-

N-phosphoryl-4-carboxy-benzenesulfonamide

-

-

N-phosphoryl-6-nitro-benzothiazole-2-sulfonamide

-

-

N-phosphoryl-benzothiazole -2-sulfonamide

-

-

n-propyl sulfamate

-

-

N-salicylidene-sulfanilic acid amide

-

-

N-salicylidene-sulfanilic acid amide cobalt acetate complex

-

-

N-salicylidene-sulfanilic acid amide cobalt chloride complex

-

-

N-salicylidene-sulfanilic acid amide cobalt nitrate complex

-

-

N-salicylidene-sulfanilic acid amide cobalt sulfate complex

-

-

N-salicylidene-sulfanilic acid amide copper chloride complex

-

-

N-salicylidene-sulfanilic acid amide copper nitrate complex

-

-

N-salicylidene-sulfanilic acid amide nickel acetate complex

-

-

N-salicylidene-sulfanilic acid amide nickel chloride complex

-

-

N-salicylidene-sulfanilic acid amide nickel nitrate complex

-

-

N-salicylidene-sulfanilic acid amide nickel sulfate complex

-

-

N-sulfamoyl-beta-D-galactopyranosylamine

-

-

N-sulfamoyl-beta-D-glucopyranosylamine

-

-

N-sulfamoyl-beta-D-mannopyranosylamine

-

-

N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide

-

-

n-tetradecyl sulfamate

show

N-trimethylsilylallylsulfonamide

-

-

n-undecyl sulfamate

-

-

N-[(1E)-(1-methyl-1H-pyrrol-2-yl)methylene]sulfamide

-

-

N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]sulfamide

-

-

N-[(1E)-(3-nitrophenyl)methylene]sulfamide

-

-

N-[(1E)-(4-methoxyphenyl)methylene]sulfamide

-

-

N-[(1E)-(4-methylphenyl)methylene]sulfamide

-

-

N-[(1E)-(4-nitrophenyl)methylene]sulfamide

-

-

N-[(1E)-(5-methylthien-2-yl)methylene]sulfamide

-

-

N-[(1E)-phenylmethylene]sulfamide

-

-

N-[(1E)-thien-2-ylmethylene]sulfamide

-

-

N-[(1E)-[4-(dimethylamino)phenyl]methylene]sulfamide

-

-

N-[(3-formyl-2-thienyl)sulfonyl]-glycine ethyl ester

-

-

N-[(3-formyl-thien-2-yl)sulfonyl]-N-(2-methoxyethyl)-glycine ethyl ester

-

-

N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-alaninamide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-phenylalaninamide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-valinamide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide

-

-

N-[(benzyloxy)carbonyl]-D-alanyl-S-benzyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-cysteinamide

-

-

N-[(benzyloxy)carbonyl]-D-methionyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-alaninamide

-

-

N-[(benzyloxy)carbonyl]-D-methionyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

N-[(benzyloxy)carbonyl]-D-methionyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-phenylalaninamide

-

-

N-[(benzyloxy)carbonyl]-D-methionyl-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-alaninamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-isoleucinamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-leucinamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-phenylalaninamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-valinamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide

-

-

N-[(benzyloxy)carbonyl]-D-phenylalanyl-S-benzyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-cysteinamide

-

-

N-[(benzyloxy)carbonyl]glycyl-N-[2-(4-sulfamoylphenyl)ethyl]-D-methioninamide

-

-

N-[(benzyloxy)carbonyl]glycyl-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide

-

-

N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]acetamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]benzamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]butanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]pentanamide

Q9ULX7, O43570, Q16790

-

N-[4-(aminosulfonyl)phenyl]propanamide

Q9ULX7, O43570, Q16790

-

N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

show

N-[[2-(1,3-dioxalan-2-yl)-3-thienyl]sulfonyl]-N-methylglycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)-2-thienyl]sulfonyl]-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(1-methylethyl)-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(2-propenyl)-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(3-methoxyethyl)-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-ethylglycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylcyclopropyl-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylglycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-propylglycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3,4-dimethoxyphenyl)methyl]-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3-methoxyphenyl)methyl]-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(4-methoxyphenyl)methyl]-glycine ethyl ester

-

-

N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[4-(morpholin-4-yl)phenyl]-glycine methyl ester

-

-

N-[[5-(aminosulfonyl)-2-formyl-thiophen-3-yl]sulfonyl]-N-methyl-glycine ethyl ester

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-alanine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-asparagine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-glutamine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-isoleucine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-leucine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-methionine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-phenylalanine

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-proline

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-tryptophan

-

-

N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-valine

-

-

NaCl

-

weak

nitrate

show

nitrite

-

OCN-

-

-

octane-1-sulfonamide

-

-

oenin

-

Orotic acid

show

p-(aminomethyl)-benzene-sulfonamide

a CAII inhibitor

p-biphenylmethyl sulfamate

-

-

p-methylbenzyl sulfamate

-

-

pentachlorophenyl sulfamate

-

-

pentafluorophenyl sulfamate

-

-

perfluorobutanesulfonamide

-

-

PH2BOH

-

-

phenol

show

phenyl sulfamate

-

-

phenylacetonitrile

-

-

phenylarsonic acid

weak inhibitor

phenylboronic acid

weak inhibitor

phenylsulfamate

-

best CA I inhibitor

phenylsulfonylsulfamic acid

-

-

piperacillin

noncompetitive inhibition

prontosil

-

prop-2-ene-1-sulfonamide

-

-

propofol

Q16790, P00918, P00915

-

pyrogallol

Q16790, P00918, P00915

-

quinolin-8-ylsulfonylsulfamic acid

-

-

resorcinol

show

resveratrol

show

rifamycin

strongest competitive inhibition

rofecoxib

-

-

RWJ-37497

-

saccharin

-

salicylic acid

show

SCN-

-

inhibits 4-nitrophenyl acetate hydrolase activity

SDS

the wild-type enzyme is inactivated at 0.4% w/v, the mutant enzymes are more stable showing residual activity at that concentration

silychristin

-

silymarin

-

a competitive inhibitor with 4-nitrophenylacetate as substrate

SO42-

show

sodium (butylsulfonyl)azanide

-

-

sodium (hexylsulfonyl)azanide

-

-

sodium (octylsulfonyl)azanide

-

-

spermine

-

-

sulfamate

-

-

sulfamic acid

show

sulfamide

show

sulfanilamide

show

sulfasalazine

-

noncompetitive inhibition of isozymes carbonic anhydrase I and II

sulfate

-

sulfonamide

-

-

Sulfonamides

-

affinity of carbonic anhydrase IV for sulfonamides is decreased up to 65fold compared to carbonic anhydrase II

sulpiride

show

sulthiame

show

tacrine

-

teicoplanin

noncompetitive inhibition

tert-butyl (2-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-2-oxoethyl)carbamate

O43570, P00918, P00915, P22748

-

tert-butyl (2-((4-methylbenzo[d]thiazol-2-yl)amino)-2-oxoethyl)-carbamate

O43570, P00918, P00915, P22748

-

tert-butyl (2-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)carbamate

O43570, P00918, P00915, P22748

-

tert-butyl 3-[[(aminosulfonyl)amino]sulfonyl]phenylcarbamate

-

-

tert-butyl 4-[[(aminosulfonyl)amino]sulfonyl]phenylcarbamate

-

-

tert-butyl 5-[[(aminosulfonyl)amino]sulfonyl]-2-hydroperoxyphenylcarbamate

-

-

thien-2-ylsulfonylsulfamic acid

-

-

thiocyanate

show

thioxolone

Q16790, P00918, P00915

-

tobramycin

uncompetitive inhibition

topiramate

show

trifluoromethanesulfonamide

show

tris(2-pyridyl)phosphine selenide

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

tris(2-pyridyl)phosphine sulfide

inhibits carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase

umbelliferone

-

-

Urea

-

-

valdecoxib

show

Vancomycin

noncompetitive inhibition

zonisamide

show

[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate

-

-

[(7,7-dimethylbicyclo[2.2.1]hept-1-yl)methyl]sulfonylsulfamic acid

-

-

[3-(trifluoromethyl)phenyl]sulfonylsulfamic acid

-

-

[3-[(tert-butoxycarbonyl)amino]-4-hydroperoxyphenyl]sulfonylsulfamic acid

-

-

[3-[(tert-butoxycarbonyl)amino]phenyl]sulfonylsulfamic acid

-

-

[4-(acetylamino)phenyl]sulfonylsulfamic acid

-

-

[4-[(tert-butoxycarbonyl)amino]phenyl]sulfonylsulfamic acid

-

-

[5-(dimethylamino)-1-naphthyl]sulfonylsulfamic acid

-

-

[Co(1-benzyl-2-methylimidazole)2Cl2]

-

[Hg(1-benzyl-2-methylimidazole)2Cl2]

-

[Zn(1-benzyl-2-methylimidazole)2Cl2]

-

[[(2-methylphenyl)sulfonyl]amino]carbonylsulfamic acid

-

-

[[(2-methylphenyl)sulfonyl]amino]carbonylsulfamic amide

-

-

[[(4-chlorophenyl)sulfonyl]amino]carbonylsulfamic acid

-

-

[[(4-chlorophenyl)sulfonyl]amino]carbonylsulfamic amide

-

-

[[(4-fluorophenyl)sulfonyl]amino]carbonylsulfamic acid

-

-

[[(4-fluorophenyl)sulfonyl]amino]carbonylsulfamic amide

-

-

[[(4-methylphenyl)sulfonyl]amino]carbonylsulfamic acid

-

-

[[(4-methylphenyl)sulfonyl]amino]carbonylsulfamic amide

-

-

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

-

-

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

-

-

additional information

show

-

back to the top

Go to Activating Compound Search

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-(naphthalen-2-ylsulfonyl)propanehydrazide hydrochloride

-

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-iodophenyl)sulfonyl]propanehydrazide hydrochloride

submicromolar activator of isoform CA II, but shows much higher affinities for isoforms CA I and IX

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methoxyphenyl)sulfonyl]propanehydrazide hydrochloride

-

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide hydrochloride

effective CA IX activator

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-nitrophenyl)sulfonyl]propanehydrazide hydrochloride

effective CA IX activator

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(pentafluorophenyl)sulfonyl]propanehydrazide hydrochloride

-

(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[[4-(trifluoromethyl)phenyl]sulfonyl]propanehydrazide hydrochloride

-

(2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

-

(2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

effective CA IX activator

(2S)-2-amino-N'-[(4-chlorophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

-

(2S)-2-amino-N'-[(4-cyanophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

-

(2S)-2-amino-N'-[(4-fluorophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

effective CA IX activator

(2S)-2-amino-N'-[(4-tert-butylphenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide hydrochloride

-

1-(2-aminoethyl)-piperazine

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,3,4,6-tetramethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,4,6-trimethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,4-dimethyl-6-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-methylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-iso-propyl-4-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-methylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-butyl-4-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-methylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-di-n-propyl-4-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-methylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diethyl-4-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-3,5-(nonane-1,9-diyl)pyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-dimethyl-4-phenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2,6-diphenyl-4-methylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-dimethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-ethyl-4,6-diphenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-dimethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-iso-propyl-4,6-diphenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-methyl-4,6-diphenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl -4,6 -dimethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-butyl-4,6-diphenylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-dimethylpyridinium hexafluorophosphate

-

-

1-[2-(1H-imidazol-4-yl)-ethyl]-2-n-propyl-4,6-diphenylpyridinium hexafluorophosphate

-

-

2-(2,5-dibromo-1H-imidazol-4-yl)ethanamine

-

-

2-(2,5-dichloro-1H-imidazol-4-yl)ethanamine

-

-

2-(2,5-diiodo-1H-imidazol-4-yl)ethanamine

-

-

2-(2-aminoethyl)pyridine

-

-

2-(5-bromo-1H-imidazol-4-yl)ethanamine

-

-

2-(5-chloro-1H-imidazol-4-yl)ethanamine

-

-

2-(5-iodo-1H-imidazol-4-yl)ethanamine

-

-

2-pyridyl-methylamine

-

-

4-(2-aminoethyl)-morpholine

-

carbonic anhydrase IV is efficiently activated by 4-(2-aminoethyl)-morpholine

4-amino-L-phenylalanine

-

carbonic anhydrase IV is efficiently activated by 4-amino-L-phenylalanine

4-methylimidazole

enzyme bound structure, PDB ID 4HEY

4-[2-(4-dimethylaminophenyl)-vinyl]-1-[2-(1H-imidazol-4-yl)ethyl]-2,6-di-isopropylpyridinium hexafluorophosphate

-

-

aminoethyl-piperazine/morpholine

-

carbonic anhydrase III is efficiently activated by aminoethyl-piperazine/morpholine

-

Br-

-

below 20 mM, activates

CAA12i

carbonic anhydrase activator 12i, enzyme binding structure determination and analysis, the location of the imidazole moiety in both conformations of CAA12i flips between two small hydrophobic cavities flanking Phe131. This movement may be analogous to the movement observed with His64 as it performs its proton-shuttling function. Conformation A may represent the in conformation of His64, as this position forms an extension of the proton wire network. In conformation B, the CAA12i tail moiety is extended away from the proton network, and this may be analogous to the out conformation of His64. Overall, the crystal structure of this CAA12i ligand indicates possible transient motion that may be essential to its activation function

citalopram

-

strong enzyme activator

Cl-

-

below 20 mM, activates

D-Dopa

-

-

D-His

-

carbonic anhydrase III is efficiently activated by D-His

D-Phe

-

-

D-Trp

-

-

dopamine

-

-

fuoxetine

-

strong enzyme activator

-

histamine

show

histidine

enzyme bound structure, PDB ID 2ABE

L-adrenaline

-

-

L-Dopa

-

-

L-His

show

L-Phe

-

-

L-Trp

-

-

L-Tyr

-

-

phenylalanine

enzyme bound structure, PDB ID 2FMG

phosphate

-

below 20 mM, activates

serotonin

-

carbonic anhydrases III and IV are efficiently activated by serotinin

sertraline

-

strong enzyme activator

tert-butyl [2-(2,5-dibromo-1H-imidazol-4-yl)ethyl]carbamate

-

-

tert-butyl [2-(2,5-dichloro-1H-imidazol-4-yl)ethyl]carbamate

-

-

tert-butyl [2-(2,5-diiodo-1H-imidazol-4-yl)ethyl]carbamate

-

-

tert-butyl [2-(5-bromo-1H-imidazol-4-yl)ethyl]carbamate

-

-

tert-butyl [2-(5-chloro-1H-imidazol-4-yl)ethyl]carbamate

-

-

tert-butyl [2-(5-iodo-1H-imidazol-4-yl)ethyl]carbamate

-

-

timolol

-

the formal name is (2S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol, timolol noncompetitively activates carbonic anhydrases I and II activities, timolol increases the value of Vmax but does not influence the value of Km

additional information

show

-

back to the top

Go to KM Value Search

6.9 - 7.5

CO2

show

2.92 - 30.53

4-nitrophenyl acetate

show

0.935 - 2.195

4-nitrophenyl phosphate

show

0.012 - 69

CO2

show

19.7 - 80.1

H2CO3

show

26 - 37

HCO3-

show

additional information

additional information

show

-

back to the top

Go to Turnover Number Search

1100000 - 25000000

CO2

show

0.0000005 - 1500000

CO2

show

28700 - 1400000

H2CO3

show

additional information

additional information

show

-

back to the top

Go to kcat/KM Value Search

5500 - 161000

CO2

show

150000

H2CO3

pH 7.5, 20°C

additional information

additional information

-

Km/kcat values for 4-nitrophenylacetate hydrolysis by wild-type and mutant enzymes, overview

-

back to the top

Go to Ki Value Search

0.021

(2E)-2-[(4-hydroxy-3-methylphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

pH 8.3, 22°C

0.00715

(2E)-2-[(4-hydroxyphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

Q16790, P00918, P00915

pH 8.3, 22°C

0.001207

(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000205

(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000198

(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.002626

(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.002639

(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000232

(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0004185

(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000181

(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001811

(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001718

(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0002273

(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001659

(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000166

(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.00152

(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001207

(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.00036

(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001432

(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000227

(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.00017

(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0000279

(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0000316

(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.00025

(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0000744

(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001716

(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000225

(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.0000837

(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000245

(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000191

(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000104

(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000177

(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000083

(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.001589

(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000037

2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000102

2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

1

2-coumaric acid

Q16790, P00918, P00915

above, pH 8.3, 22°C

0.000039

2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000057 - 0.00051

3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

show

0.000033 - 0.001

3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

show

0.000009 - 0.00021

3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

show

0.000014

3-[(anilinocarbonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.00005

4,5-dichloro-benzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX, i.e. daranide

0.00002

4-(2-methylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

pH and temperature not specified in the publication

0.000099

4-(3-formylphenyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

pH and temperature not specified in the publication

0.0000002

4-(3-quinolinyl)benzene-1-sulfonamide

O43570, Q16790, P00918, P00915

pH and temperature not specified in the publication

0.000012

4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000033

4-aminoethylbenzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.0000002

4-phenylbenzene-1-sulfonamide

O43570, Q16790, P00918, P00915

pH and temperature not specified in the publication

0.001442

4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000093

4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme hCA IX, pH 9.0, 40°C

0.000037

4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000146

4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000113

4-[(methylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000052

4-[(phenylsulfonyl)amino]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000021

4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000018

4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000003

4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000026

4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.00004

4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.00046 - 0.0021

4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide

show

0.000021

5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000016

5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000039

6-chloro-4-amino-benzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000052

6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000024

6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000009 - 0.002325

acetazolamide

show

0.000037

brinzolamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX catalytic domain

0.115

catechol

Q16790, P00918, P00915

pH 8.3, 22°C

0.00405

curcumin

Q16790, P00918, P00915

pH 8.3, 22°C

0.00982

dobutamine

Q16790, P00918, P00915

pH 8.3, 22°C

0.000052

dorzolamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000034 - 0.00005

ethoxzolamide

show

0.00042

Furosemide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.0096

H2NSO2NH2

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

0.0092

H2NSO3H

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

0.000103

homosulfanilamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000367

hydrochlorothiazide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000481

N-(1-(2-hydroxyphenylamino)-3-methyl-1-oxobutan-2-ylcarbamothioyl)benzamide

Q16790, P00918, P00915

above, pH 8.3, 22°C

0.00049

N-(1-(2-hydroxyphenylamino)-4-methyl-1-oxopentan-2-ylcarbamothioyl) benzamide

Q16790, P00918, P00915

above, pH 8.3, 22°C

0.000013

N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000865

N-hydroxysulfamide

O43570, Q16790, P00918, P00915

isoenzyme hCA IX

0.000112

N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000136

N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000139

N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000135

N-[4-(aminosulfonyl)phenyl]acetamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000073

N-[4-(aminosulfonyl)phenyl]benzamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000083

N-[4-(aminosulfonyl)phenyl]butanamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000079

N-[4-(aminosulfonyl)phenyl]pentanamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000106

N-[4-(aminosulfonyl)phenyl]propanamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000027

N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.0088

phenol

Q16790, P00918, P00915

pH 8.3, 22°C

0.0697

resorcinol

Q16790, P00918, P00915

pH 8.3, 22°C

0.00787

salicylic acid

Q16790, P00918, P00915

pH 8.3, 22°C

0.000294

sulfanilamide

Q9ULX7, O43570, Q16790

pH 7.5, catalytic domain of cloned isoenzyme

0.000043

sulthiame

Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.000058

topiramate

Q9ULX7, O43570, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX

0.0000051

zonisamide

O14939, Q9ULX7, Q16790, P00918, P07451, P00915, P22748, P35218, Q9Y2D0, P23280, P43166

isoenzyme hCA IX catalytic domain

0.0000419

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.0002213

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.000025

[[(eta5-C5H4)-C(CH3)=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.0000499

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]FeCp

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.0000021

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]Mn(CO)3

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.0005798

[[(eta5-C5H4)-CH=N-N(H)-C6H4-4-SO2NH2]]re(CO)3

O43570, Q16790, P00918, P00915

isoform CA IX, at pH 7.5 and 25Â°C

-

0.0004 - 0.0015

(2,4,6-triisopropylphenyl)sulfonylsulfamic acid

show

0.0008 - 0.0021

(2,4,6-tripropylphenyl)sulfonylsulfamic acid

show

0.00001 - 0.0001

(2,5-dichlorophenyl)sulfonylsulfamic acid

show

0.0009 - 0.0012

(2-nitrophenyl)sulfonylsulfamic acid

show

0.00334 - 0.35

(2E)-2-[(4-hydroxy-3-methylphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

show

0.00383 - 0.00803

(2E)-2-[(4-hydroxyphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide

show

0.000098 - 0.284

(2E)-4-methoxy-4-oxobut-2-enoic acid

show

0.00009 - 0.395

(2E)-but-2-enedioic acid

show

0.000095 - 0.239

(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid

show

0.000102 - 0.231

(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid

show

0.0003 - 0.0005

(3,5-dichloro-2-hydroxyphenyl)sulfonylsulfamic acid

show

0.0001 - 0.265

(3-chloro-4-hydroxyphenyl)acetic acid

show

0.00009 - 0.0003

(3-chloro-4-nitrophenyl)sulfonylsulfamic acid

show

0.000085 - 0.244

(3-chlorophenyl)acetic acid

show

0.0002 - 0.0005

(3-nitrophenyl)sulfonylsulfamic acid

show

0.0000038 - 0.00025

(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate

show

0.0018 - 0.0036

(4-acetylphenyl)sulfonylsulfamic acid

show

0.01

(4-bromophenyl)sulfonylsulfamic acid

show

0.01

(4-chlorophenyl)sulfonylsulfamic acid

show

0.01

(4-fluorophenyl)sulfonylsulfamic acid

show

0.000099 - 0.309

(4-hydroxyphenyl)acetic acid

show

0.009 - 0.01

(4-iodophenyl)sulfonylsulfamic acid

show

0.003 - 0.01

(4-methoxyphenyl)sulfonylsulfamic acid

show

0.01

(4-methylphenyl)sulfonylsulfamic acid

show

0.0001 - 0.0004

(4-nitrophenyl)sulfonylsulfamic acid

show

0.000076 - 0.355

(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one

show

0.00007 - 0.0105

(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one

show

0.0000267 - 0.0000308

(E)-3-iodo-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0018 - 0.007

(heptadecafluorooctyl)sulfonylsulfamic acid

show

0.003 - 0.01

(nonafluorobutyl)sulfonylsulfamic acid

show

0.000003 - 0.00001

(pentafluorophenyl)sulfonylsulfamic acid

show

0.0000036 - 0.0000076

(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000334 - 0.0001334

(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000029 - 0.0000389

(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

show

0.0000051 - 0.0000572

(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000669 - 0.0004557

(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

show

0.000002 - 0.000029

(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000377

(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme, pH 9.0, 40°C

0.0000023 - 0.0003802

(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.000019 - 0.0000323

(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000017 - 0.0000054

(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000046 - 0.0000494

(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000033 - 0.0000556

(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000443

(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme, pH 9.0, 40°C

0.000004 - 0.0000539

(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000023 - 0.0000048

(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000026 - 0.000007

(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000036 - 0.0000076

(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000062 - 0.0000516

(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0003425 - 0.0003586

(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000078 - 0.0000613

(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.000006 - 0.0000096

(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one

show

4.1

(S)-2-(2-ammoniopropanamido)-4-methylbenzo[d]thiazol-3-ium di-2,2,2-trifluoroacetate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

0.000046 - 0.0000889

(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide

show

0.0000725 - 0.000186

(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.000707

(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme, pH 9.0, 40°C

0.0000083 - 0.0000733

(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.000006 - 0.0000797

(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.000146 - 0.0005686

(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000293 - 0.0000834

(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000076 - 0.0000668

(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000828

(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

Q16790, P00918, P00915, P22748

inhibition of isozyme, pH 9.0, 40°C

0.000015 - 0.000068

(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide

show

0.0000054 - 0.0000295

(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.000002 - 0.000139

(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000927 - 0.0005426

(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000078 - 0.0003303

(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000622 - 0.000245

(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.005 - 0.0711

(S)-benzyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxopropan-2-yl)carbamate

show

0.0726

(S)-benzyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

0.0847

(S)-tert-butyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

4.1

(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

0.086

(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

0.0454

(S)-tert-butyl (1-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

O43570, P00918, P00915, P22748

pH 7.5, 22°C

0.01 - 0.02

(trichloromethyl)sulfonylsulfamic acid

show

0.01 - 0.02

(trifluoromethyl)sulfonylsulfamic acid

show

0.00143 - 0.0078

1,2,4-trimethoxybenzene

show

0.0005 - 0.0104

1,2-dimethoxybenzene

show

0.000029 - 0.000315

1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate

show

0.000015 - 0.000278

1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate

show

0.0000177 - 0.0000182

1,3-bis(4-bromobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.1664 - 0.3162

1,3-dimethylpyrimidine-2,4(1H,3H)-dione

show

0.00335 - 0.00821

1,4-dimethoxybenzene

show

0.000035

1-(1,2-benzoxazol-3-yl)methanesulfonamide

-

wild-type, pH 7.5, 20°C

0.000112 - 0.000273

1-(3-cyanobenzyl)-3-(2,3,4,5,6-pentamethyl-benzyl)-3H-benzoimidazol-1-ium bromide

show

0.000174 - 0.000189

1-(3-cyanobenzyl)-3-(2,3,5,6-tetramethyl-benzyl)-3H-benzoimidazol-1-ium bromide

show

0.000195 - 0.000352

1-(3-cyanobenzyl)-3-(2,4,6-trimethyl-benzyl)-3H-benzoimidazol-1-ium bromide

show

0.000225 - 0.000277

1-(3-cyanobenzyl)-3-(2-methylbenzyl)-3H-benzoimidazol-1-ium bromide

show

0.000213 - 0.000402

1-(3-cyanobenzyl)-3-(4-methylbenzyl)-3H-benzoimidazol-1-ium bromide

show

0.0000164 - 0.0000205

1-(3-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000286 - 0.0000316

1-(4-chlorobenzyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000804

1-benzyl-3-(2,4,6-trimethoxybenzyl)-2-methylimidazolium chloride

pH not specified in the publication, temperature not specified in the publication

0.0000279

1-benzyl-3-(N-methyphthalimide)-2-methylimidazolium bromide

pH not specified in the publication, temperature not specified in the publication

0.0000262 - 0.0000337

1-benzyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000378

1-benzyl-3-[2-(4-hydroxyphenyl)ethyl]-2-methylimidazolium bromide

pH not specified in the publication, temperature not specified in the publication

0.0000099 - 0.0000443

1-butyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000055 - 0.00065

1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0004 - 0.35

1-cyclopentyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0000047 - 0.00378

1-cyclopropyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0000384

1-decyl-3-(2,4,6-trimethoxybenzyl)-2-methylimidazolium chloride

pH not specified in the publication, temperature not specified in the publication

0.0000789

1-decyl-3-(N-methyphthalimide)-2-methylimidazolium bromide

pH not specified in the publication, temperature not specified in the publication

0.0000659

1-decyl-3-[2-(4-hydroxyphenyl)ethyl]-2-methylimidazolium bromide

pH not specified in the publication, temperature not specified in the publication

0.0000064 - 0.00395

1-n-butyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0015 - 0.0032

1-naphthylsulfonylsulfamic acid

show

0.000048 - 0.0089

1-[(2-oxo-2H-chromen-6-yl)methyl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane

show

0.00046 - 0.0044

1-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-4-(4-sulfamoylphenyl)-1H-1,2,3-triazole

show

0.000142 - 1

1H,1H,2H,2H-perfluorodecyl sulfamate

show

0.000335 - 0.4

1H,1H,2H,2H-perfluorooctyl sulfamate

show

0.000458 - 0.0078

1H,1H-perfluoroethyl sulfamate

show

0.000279 - 0.00354

1H-perfluoroisopropyl sulfamate

show

0.0000091 - 0.0000547

2,2'-(1-(4-bromophenyl)ethane-1,1-diyl)bis(sulfanediyl)diacetic acid

show

0.0000199 - 0.0000296

2,2'-(1-(4-methoxyphenyl)ethane-1,1-diyl)bis(sulfanediyl)bis(N-(pyridin-2-yl)acetamide)

show

0.0000199 - 0.0000363

2,2'-(1-(4-methoxyphenyl)ethane-1,1-diyl)bis(sulfanediyl)diacetic acid

show

0.0000248 - 0.000065

2,2'-(1-(4-nitrophenyl)ethane-1,1-diyl)bis(sulfanediyl)bis(N-(pyridin-2-yl)acetamide)

show

0.0000202 - 0.0000656

2,2'-(1-phenylethane-1,1-diyl)bis(sulfanediyl)bis(N-benzylacetamide)

show

0.000025 - 0.0000524

2,2'-(1-phenylethane-1,1-diyl)bis(sulfanediyl)bis(N-p-tolylacetamide)

show

0.0000065 - 0.008637

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine

show

0.0000054 - 0.003714

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine

show

0.000005 - 0.009703

2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine

show

0.0000053 - 0.00953

2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine

show

0.000037 - 0.000454

2,4,6-trichlorophenyl sulfamate

show

0.0000067 - 0.0000762

2,4-bis(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.000823 - 0.00967

2,6-dimethoxybenzoic acid

show

0.0000355 - 0.0000628

2-((2,6-dichlorobenzyl)thio)-6-phenyl-5-(piperidin-1-ylmethyl) imidazo[2,1-b][1,3,4]-thiadiazole

show

0.0000169 - 0.0000433

2-((2,6-dichlorobenzyl)thio)-6-phenyl-5-(pyrrolidin-1-ylmethyl) imidazo[2,1-b][1,3,4]-thiadiazole

show

0.0000291 - 0.0000308

2-((2,6-dichlorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

show

0.0000103 - 0.0000515

2-((2,6-difluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

show

0.0000125 - 0.0000238

2-((2-chloro-6-fluorobenzyl)thio)-6-(3,4-dichlorophenyl)imidazo [2,1-b][1,3,4]thiadiazole

show

0.0000203 - 0.0000456

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

show

0.0000234 - 0.0000257

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

show

0.0000214 - 0.0000636

2-((2-chloro-6-fluorobenzyl)thio)-6-(4-methoxyphenyl)imidazo [2,1-b][1,3,4]thiadiazole

show

0.0000198 - 0.0000342

2-((2-chloro-6-fluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole

show

0.000084 - 0.158

2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide

show

0.000091 - 0.0098

2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide

show

0.000079 - 0.0119

2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

show

0.000087 - 0.0112

2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide

show

0.000018 - 0.0007

2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide

show

0.000106 - 0.237

2-(3-chloro-4-hydroxyphenyl)acetamide

show

0.0000009 - 45

2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

show

0.0000048 - 0.0000107

2-(4-hydroxybenzylidene)-2H-indene-1,3-dione

show

0.000081 - 0.309

2-(4-hydroxyphenyl)acetamide

show

0.0000072 - 1.4

2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide

show

0.00001 - 0.806

2-(phenylethynyl)benzenesulfonamide

show

0.0000315 - 0.0000639

2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate

show

0.00595

2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide

-

wild-type, pH 7.5, 20°C

0.000772 - 0.887

2-aminobenzenesulfonamide

show

0.0031 - 0.0092

2-coumaric acid

show

0.00109 - 1.995

2-hydrazinobenzenesulfonamide

show

0.00000061 - 0.36

2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide

show

0.000012 - 0.0012

2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala

show

0.000006 - 0.000027

2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn

show

0.000009 - 0.00004

2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln

show

0.000004 - 0.000022

2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile

show

0.000005 - 0.000021

2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu

show

0.000004 - 0.000027

2-N-(4-sulfamoylphenyl)-thioformyl-L-Met

show

0.000006 - 0.00003

2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe

show

0.000025 - 0.00011

2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro

show

0.000011 - 0.000047

2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp

show

0.000005 - 0.000023

2-N-(4-sulfamoylphenyl)-thioformyl-L-Val

show

0.00004 - 0.000063

2-naphthyl sulfamate

show

0.000103

2-naphthylsulfamate

-

pH 7.4, 25°C, hCA I

0.0012 - 0.0034

2-naphthylsulfonylsulfamic acid

show

0.0038 - 0.0447

2-oxo-2H-chromene-3-carboxylic acid

show

0.000047 - 0.009

2-oxo-2H-thiochromene-3-carboxylic acid

show

0.0000011 - 0.0041

2-phenylethyl sulfamate

show

0.0031 - 0.5

2H-chromen-2-one

show

0.0000048 - 0.00083

3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine

show

0.0000078 - 0.00083

3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine

show

0.000006 - 0.00151

3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.00047 - 0.00445

3,4-dihydroxybenzoic acid

show

0.00618 - 0.00825

3,4-dimethoxybenzoic acid

show

0.000367 - 0.00441

3,5-Dihydroxybenzoic acid

show

0.0000013 - 0.000087

3-(phenylethynyl)benzenesulfonamide

show

0.00057 - 0.00462

3-chloropropyl sulfamate

show

0.000353 - 0.00453

3-Hydroxybenzoic acid

show

0.0000245 - 0.0000352

3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000155 - 0.0000514

3-iodo-1-(prop-2-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000156 - 0.0000231

3-iodo-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000172 - 0.0000195

3-iodo-1-propyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

show

0.0000019

3-methylphenyl sulfamate

-

pH 7.4, 25°C, hCA II

0.0000038

3-methylphenylsulfamate

-

pH 7.4, 25°C, hCA I

10.57 - 11.42

3-methylsalicylic acid

show

0.000012 - 0.416

3-phenylpropanenitrile

show

0.000001 - 0.00214

3-[(3-fluorophenyl)ethynyl]benzenesulfonamide

show

0.0000017 - 0.006315

3-[(3-methoxyphenyl)ethynyl]benzenesulfonamide

show

0.0000011 - 0.00171

3-[(4-methylphenyl)ethynyl]benzenesulfonamide

show

0.00001 - 0.00145

3-[(anilinocarbonyl)amino]benzenesulfonamide

show

0.000006 - 0.00001

3-[(sulfoamino)sulfonyl]benzoic acid

show

0.00007 - 0.0008

3-[[(aminosulfonyl)amino]sulfonyl]benzoic acid

show

0.0000047 - 0.01117

4,4'-thiodipyridine-3-sulfonamide

show

0.000069 - 0.368

4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)

show

0.000079 - 0.354

4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)

show

0.000071 - 0.307

4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)

show

0.000021 - 0.015

4,5-dichloro-benzene-1,3-disulfonamide

show

0.000038 - 0.00005

4,5-dichlorobenzene-1,3-disulfonamide

show

0.00545 - 0.01485

4,6-dinitrosalicylic acid

show

0.0000288 - 0.0000356

4-((2-((2,6-dichlorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazol-5-yl)methyl)-morpholine

show

0.0000248 - 0.0000323

4-((2-((2,6-difluorobenzyl)thio)-6-phenylimidazo[2,1-b][1,3,4] thiadiazol-5-yl)methyl)-morpholine

show

0.0000203 - 0.0000288

4-((2-((2-chloro-6-fluorobenzyl)thio)-6-phenylimidazo[2,1-b] [1,3,4]thiadiazol-5-yl)methyl)morpholine

show

0.0000051 - 0.00667

4-(1,3,4-thiadiazol-2-ylthio)pyridine-3-sulfonamide

show

0.0000042 - 0.00653

4-(1-methyl-5-tetrazolylthio)pyridine-3-sulfonamide

show

0.0000227 - 0.000105

4-(2-((2-chloro-6-fluorobenzyl)thio)imidazo[2,1-b][1,3,4] thiadiazol-6-yl)benzonitrile

show

0.00016 - 1.6

4-(2-aminoethyl)benzenesulfonamide

show

0.000125 - 1.187

4-(2-hydroxyethyl)benzenesulfonamide

show

0.000101 - 0.43

4-(2-hydroxyethyl)phenol

show

0.0000067 - 0.01032

4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide

show

0.0000012 - 0.0035

4-(2-methylphenyl)benzene-1-sulfonamide

show

0.0000053

4-(2-phenylacetamido)-3-bromobenzenesulfonamide

-

isoform CA VII

0.0000069

4-(2-phenylacetamido)-3-chlorobenzenesulfonamide

-

isoform CA VII

0.0000054

4-(2-phenylacetamido)-3-fluorobenzenesulfonamide

-

isoform CA VII

0.0000047

4-(2-phenylacetamido)benzenesulfonamide

-

isoform CA VII

0.0000055

4-(2-phenylacetamidoethyl)benzenesulfonamide

-

isoform CA VII

0.0000068

4-(2-phenylacetamidomethyl)benzenesulfonamide

-

isoform CA VII

0.0000063 - 0.00832

4-(2-propynylthio)pyridine-3-sulfonamide

show

0.0000077

4-(2-pyridin-2-ylacetamido)benzenesulfonamide

-

isoform CA VII

0.0000079

4-(2-pyridin-4-ylacetamido)benzenesulfonamide

-

isoform CA VII

0.0000085

4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide

-

isoform CA VII

0.0000006 - 0.0012

4-(3-formylphenyl)benzene-1-sulfonamide

show

0.0000025 - 0.00076

4-(3-quinolinyl)benzene-1-sulfonamide

show

0.00003 - 0.000638

4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide

show

0.000312 - 0.000752

4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide

show

0.000277 - 0.000706

4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide

show

0.000046 - 0.000665

4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide

show

0.000863 - 0.0042

4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide

show

0.0000063 - 0.00664

4-(4-cyanophenoxy)-3-pyridinesulfonamide

show

0.0000069 - 0.00916

4-(4-fluorophenoxy)-3-pyridinesulfonamide

show

0.0000075 - 0.0000686

4-(4-hydroxyphenyl)-2-(3-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.0000052 - 0.0000597

4-(4-hydroxyphenyl)-2-(4-bromophenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.000005 - 0.0000673

4-(4-hydroxyphenyl)-2-(4-chlorophenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.0000085 - 0.0000737

4-(4-hydroxyphenyl)-2-(4-fluorophenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.0000073 - 0.0000745

4-(4-hydroxyphenyl)-2-(4-methoxyphenyl)-5H-indeno[1,2-b]pyridin-5-one

show

0.0000047 - 0.0000714

4-(4-hydroxyphenyl)-2-p-tolyl-5H-indeno[1,2-b]pyridin-5-one

show

0.0000068 - 0.0000673

4-(4-hydroxyphenyl)-2-phenyl-5H-indeno[1,2-b]pyridin-5-one

show

0.0000078 - 0.0103

4-(5-methyl-2-pyrazolino)-3-pyridinesulfonamide

show

0.00000216 - 0.00884

4-(6-nitrobenzothiazol-2-ylthio)pyridine-3-sulfonamide

show

0.000012 - 0.00886

4-(allylamino)-3-pyridinesulfonamide

show

0.0048 - 0.681

4-(aminomethyl)benzenesulfonamide

show

0.000013 - 1.06

4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide

show

0.000887 - 0.0113

4-(aminosulfonyl)benzoic acid

show

0.0000118 - 0.00951

4-(carbamoylmethylthio)pyridine-3-sulfonamide

show

0.0000117 - 0.01171

4-(cyanomethylthio)pyridine-3-sulfonamide

show

0.00668 - 4.89

4-(hydroxymethyl)benzenesulfonamide

show

0.0000089 - 0.000562

4-(methylhydrazino)-3-pyridinesulfonamide

show

0.0000075 - 0.00762

4-(N-oxide-2-pyridylthio)pyridine-3-sulfonamide

show

0.0000094 - 0.00565

4-(phenylethynyl)benzenesulfonamide

show

0.0000068 - 0.01032

4-(quinolinoxy)-3-pyridinesulfonamide

show

0.0025 - 0.0036

4-acetyl-N-(aminosulfonyl)benzenesulfonamide

show

0.000018 - 0.000045

4-acetylamidophenyl sulfamate

show

0.0107

4-amino-3,5-dibromobenzenesulfonamide

20°C, pH 7.5

0.00468

4-amino-3-bromobenzenesulfonamide

20°C, pH 7.5, full-length recombinant hCA VI

0.001097 - 0.71

4-amino-3-chlorobenzenesulfonamide

show

0.019

4-amino-3-fluoro-5-iodobenzenesulfonamide

20°C, pH 7.5

0.00006 - 2.075

4-amino-3-fluorobenzenesulfonamide

show

0.001024

4-amino-3-iodobenzenesulfonamide

20°C, pH 7.5, full-length recombinant hCA VI

0.000955 - 1.276

4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide

show

0.000075 - 0.0097

4-amino-6-chlorobenzene-1,3-disulfonamide

show

0.000024 - 0.14

4-amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzenesulfonamide

show

0.000055 - 0.114

4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide

show

0.000037 - 0.988

4-Aminobenzenesulfonamide

show

0.0000032 - 0.0029

4-aminoethylbenzenesulfonamide

show

0.24 - 1.23

4-aminosalicylic acid

show

0.0000065 - 0.00909

4-benzythiopyridine-3-sulfonamide

show

0.00005 - 0.000113

4-biphenyl sulfamate

show

0.000068 - 0.000081

4-bromobenzenesulfonamide

show

0.0000073 - 0.000019

4-bromophenyl sulfamate

show

0.0000175 - 0.000053

4-chlorobenzenesulfonamide

show

0.0000046 - 0.000018

4-chlorophenyl sulfamate

show

0.000041 - 0.00048

4-cyanophenyl sulfamate

show

0.000149

4-cyanophenylsulfamate

-

pH 7.4, 25°C, hCA II

0.0000059 - 0.0061

4-ethoxy-3-pyridinesulfonamide

show

0.0000051 - 0.00108

4-ethynylbenzenesulfonamide

show

0.0000049 - 0.00791

4-hydrazino-3-pyridinesulfonamide

show

0.001275

4-hydrazinobenzenesulfonamide

20°C, pH 7.5, full-length recombinant hCA VI

0.000088 - 0.000089

4-hydroxybenzenesulfonamide

show

0.00007 - 0.000081

4-iodobenzenesulfonamide

show

0.0000038 - 0.000023

4-iodophenyl sulfamate

show

0.0000057 - 0.00734

4-methoxy-3-pyridinesulfonamide

show

0.000033 - 0.000034

4-methoxyphenyl sulfamate

show

0.001582 - 0.0079

4-methylbenzenesulfonamide

show

0.000059

4-methylphenyl sulfamate

-

pH 7.4, 25°C, hCA IX

0.0000067 - 0.00983

4-methylthiopyridine-3-sulfonamide

show

0.000036

4-nitrophenyl sulfamate

-

pH 7.4, 25°C, hCA IX

0.00004

4-nitrophenylsulfamate

-

pH 7.4, 25°C, hCA I

0.000051 - 0.000115

4-phenoxyphenyl sulfamate

show

0.0000008 - 0.000093

4-phenylbenzene-1-sulfonamide

show

0.48 - 1.06

4-sulfosalicylic acid

show

0.0000029 - 0.000043

4-t-butylphenyl sulfamate

show

0.000054 - 0.000138

4-trifluoromethylphenyl sulfamate

show

0.000086 - 2.633

4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide

show

0.0000056 - 0.0000087

4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000754 - 0.0004219

4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide

show

0.0000058 - 0.000076

4-[(3-fluorophenyl)ethynyl]benzenesulfonamide

show

0.0000016 - 0.00529

4-[(3-hydroxyphenyl)ethynyl]benzenesulfonamide

show

0.0000012 - 0.00489

4-[(3-methoxyphenyl)ethynyl]benzenesulfonamide

show

0.0000116 - 0.0000663

4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]-2-methoxyphenyl methanesulfonate

show

0.0000106 - 0.0000604

4-[(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl]phenylmethanesulfonate

show

0.000068 - 0.00559

4-[(4-methylphenyl)ethynyl]benzenesulfonamide

show

0.000076 - 0.00088

4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide

show

0.000348 - 0.00043

4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide

show

0.000033 - 0.00125

4-[(methylsulfonyl)amino]benzenesulfonamide

show

0.000068 - 0.000935

4-[(phenylsulfonyl)amino]benzenesulfonamide

show

0.000008 - 0.00001

4-[(sulfoamino)sulfonyl]benzoic acid

show

0.0000076

4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide

-

isoform CA VII

0.0000071

4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide

-

isoform CA VII

0.0000072

4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide

-

isoform CA VII

0.0000069

4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide

-

isoform CA VII

0.000007

4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide

-

isoform CA VII

0.0000062

4-[2-(2-thienyl)acetamido]benzenesulfonamide

-

isoform CA VII

0.0000075 - 0.00152

4-[2-(4-sulfamoylphenyl)ethylamino]-3-pyridinosulfonamide

show

0.000024 - 0.000203

4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide

show

0.000013 - 0.00026

4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide

show

0.000079 - 0.000085

4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide

show

0.0000016 - 0.000005

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole

show

0.0000087 - 0.0043

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole

show

0.0000091 - 0.0044

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole

show

0.0000082 - 0.000134

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole

show

0.0000099 - 0.00013

4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

show

0.0001 - 0.0053

4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole

show

0.000101 - 0.005

4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole

show

0.000085

4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole

-

isozyme CA IX, in 10 mM HEPES (pH 7.5), 0.1 M NaClO4, at 20°C

0.0000023 - 0.000028

4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole

show

0.0000028 - 0.0000076

4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole

show

0.0000093 - 0.00012

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole

show

0.0000089 - 0.00038

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole

show

0.0000084 - 0.00056

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

show

0.00013 - 0.005

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole

show

0.0000075 - 0.0043

4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole

show

0.00012 - 0.0025

4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole

show

0.000021

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

-

wild-type, pH 7.5, 20°C

0.0000046 - 0.0089

4-[N'-(1,1-dioxopyrido[4,3-e]-1,4,2-dithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

show

0.0000034 - 0.0000923

4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

show

0.0000081

4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide

-

isoform CA XII, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4, at 22°C

0.0000058 - 0.000101

4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazyno]-3-pyridinesulfonamide

show

0.00006 - 0.0007

4-[[(aminosulfonyl)amino]sulfonyl]benzoic acid

show

0.000018 - 0.000237

4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide

show

0.000083 - 0.000465

4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide

show

0.0001035 - 0.000236

5,6-diamino-1,3-dimethyluracil

show

0.000114 - 0.0146

5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide

show

0.0000061

5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide

-

isoform CA VII

0.000012

5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide

-

wild-type, pH 7.5, 20°C

0.04951

5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione

pH 7.4, temperature not specified in the publication

0.025 - 0.236

5-acetamido-1,3,4-thiadiazole-2-sulfonamide

show

0.000033 - 0.148

5-amino-1,3,4-thiadiazole-2-sulfonamide

show

0.01083 - 0.02888

5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione

show

0.428 - 0.645

5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione

show

0.00127 - 0.00416

5-chlorosalicylic acid

show

0.00074 - 0.198

5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide

show

0.000105

5-pentylresorcinyl sulfamate

-

pH 7.4, 25°C, hCA I

0.000043 - 0.000076

5-pentylresorcinylsulfamate

show

0.77 - 1.92

5-sulfosalicylic acid

show

0.0000069

5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide

-

isoform CA VII

0.0805

5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

20°C, pH 7.5

0.000073 - 0.0181

5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

show

0.0000033 - 0.000013

5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

show

0.0000019 - 0.00001

5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide

show

0.0000094 - 0.0028

6,7-dimethoxy-1-ethyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.000302 - 0.235

6,7-dimethoxy-1-isopropyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0000095 - 0.00641

6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.00386 - 0.0157

6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.0000763 - 0.002754

6,7-dimethoxy-1-propyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide

show

0.000059 - 0.5

6-((1S)-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one

show

0.0000486 - 0.000078

6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one

show

0.0000151 - 0.0000625

6-(4-bromophenyl)-2-((2-chloro-6-fluorobenzyl)thio)imidazo[2,1-b][1,3,4]thiadiazole

show

0.0037 - 0.0097

6-(aminomethyl)-2H-chromen-2-one

show

0.0043 - 0.0445

6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid

show

0.000093 - 0.0324

6-(hydroxymethyl)-2H-chromen-2-one

show

0.0000216 - 0.0000385

6-([1,1'-biphenyl]-4-yl)-2-((2-chloro-6-fluorobenzyl)thio)imidazo [2,1-b][1,3,4]thiadiazole

show

0.0777

6-acetyl-7-adamantylethoxy-2H-chromen-2-one

-

inhibition of isozyme hCA XII, pH not specified in the publication, temperature not specified in the publication

0.0074

6-acetyl-7-ethoxy-2H-chromen-2-one

-

inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication

0.00803

6-acetyl-7-hydroxy-2H-chromen-2-one

-

inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication

0.00654 - 0.0078

6-acetyl-7-methoxy-2H-chromen-2-one

show

0.00758

6-acetyl-7-propoxy-2H-chromen-2-one

-

inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication

0.000085 - 0.0001715

6-amino-1,3-dimethyluracil

show

0.000044 - 0.0084

6-chloro-4-amino-benzene-1,3-disulfonamide

show

0.00314 - 0.5

6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine

show

0.000008

6-ethoxy-1,3-benzothiazole-2-sulfonamide

-

wild-type, pH 7.5, 20°C

0.000103

6-hydroxy-1,3-benzothiazole-2-sulfonamide

20°C, pH 7.5, full-length recombinant hCA VI

0.0049 - 0.0396

6-methoxy-2-oxo-2H-chromene-3-carboxylic acid

show

0.0056 - 0.0425

6-methyl-2-oxo-2H-chromene-3-carboxylic acid

show

0.0000035 - 8

6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide

show

0.05776

6-methylpyrimidine-2,4(1H,3H)-dione

pH 7.4, temperature not specified in the publication

0.000045 - 0.0094

6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide

show

0.000012 - 0.7

667-coumate

show

0.000243 - 0.0694

7-(2-phenylethoxy)-2H-chromen-2-one

show

0.000224 - 0.0651

7-(benzyloxy)-2H-chromen-2-one

show

0.000213 - 0.0764

7-butoxy-2H-chromen-2-one

show

0.0016 - 0.0609

7-ethoxy-2H-chromen-2-one

show

0.0000332 - 0.0000467

7-ethoxy-8-propanoyl-2H-chromen-2-one

show

0.000093 - 0.201

7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid

show

0.000094 - 0.374

7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid

show

0.008015

7-hydroxy-6-propanoyl-2H-chromen-2-one

-

inhibition of isozyme hCA IX, pH not specified in the publication, temperature not specified in the publication

0.0000582 - 0.0000617

7-hydroxy-8-propanoyl-2H-chromen-2-one

show

0.000099 - 0.5

7-methoxy-2-oxo-2H-chromene-4-carboxylic acid

show

0.000066 - 0.5