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Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Homo sapiens and UniProt Accession P23280

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.1 carbonic anhydrase
IUBMB Comments
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: P23280
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
(CA) XIV, AaCA1, alkalistable alpha-carbonic anhydrase, alpha carbonic anhydrase, alpha class carbonic anhydrase, alpha-CA, alpha-carbonic anhydrase, alpha-carbonic anhydrase isozyme II, alpha-class carbonic anhydrase, alpha-type CA, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-CA
alpha-carbonic anhydrase
247
-
alpha-class carbonic anhydrase
247
-
anhydrase
-
-
-
-
bCA IV
247
-
CA II
CA III
CA IV
CA IX
CA VA
CA VB
CA VI
CA VII
CA VIII
291276
-
CA XII
CA XIII
CA XIV
CA-II
CA-III
282978
-
CA-IX
-
-
-
-
CA-VA
-
-
-
-
CA-VB
-
-
-
-
CA-VI
CA-VII
-
-
-
-
CA-XII
-
-
-
-
CA-XIV
-
-
-
-
CA4
282981
-
CA5A
282982
-
CAI
247
-
CAIII
247
-
carbonate anhydrase
-
-
-
-
Carbonate dehydratase
-
-
-
-
carbonate dehydratase III
282978
-
Carbonate dehydratase IX
-
-
-
-
Carbonate dehydratase VA
-
-
-
-
Carbonate dehydratase VB
-
-
-
-
Carbonate dehydratase VI
Carbonate dehydratase VII
-
-
-
-
Carbonate dehydratase XII
-
-
-
-
Carbonate dehydratase XIV
-
-
-
-
carbonic acid anhydrase
-
-
-
-
carbonic anhydrase
carbonic anhydrase 1
282980
-
carbonic anhydrase 14
279094
-
carbonic anhydrase 2
282976
-
carbonic anhydrase 3
282978
-
carbonic anhydrase 5A
282982
-
carbonic anhydrase 9
279096
-
carbonic anhydrase I
carbonic anhydrase I (CA I) Michigan 1
282980
-
carbonic anhydrase II
carbonic anhydrase III
carbonic anhydrase isozyme I
247
-
carbonic anhydrase isozyme II
247
-
carbonic anhydrase isozyme III
282978
-
carbonic anhydrase isozyme IV
247
-
carbonic anhydrase isozyme IX
247
-
carbonic anhydrase IV
carbonic anhydrase IX
carbonic anhydrase V
247
-
carbonic anhydrase VA
282982
-
carbonic anhydrase VI
carbonic anhydrase VII
247
-
carbonic anhydrase XII
carbonic anhydrase XIII
247
-
carbonic anhydrase XIV
279094
-
carbonic anhydrase-I
carbonic anhydrase-II
247
isozyme
carbonic anhydrase-related protein VIII
291276
-
carbonic dehydratase
-
-
-
-
carboxyanhydrase
-
-
-
-
CAVA
282982
-
CAXII
247
isoform
dehydratase, carbonate
-
-
-
-
H64A HCA II
282976
-
HC II
247
-
hCA I
HCA II
hCA III
hCA IV
hCA IX
hCA VA
282982
-
hCA VB
282983
-
hCA VII
282985
-
hCA XII
hCA XIV
279094
-
hCA XIV catalytic domain
279094
-
HCA-I
247
-
HCA-II
247
-
hCAII
human carbonic anhydrase
247
-
human carbonic anhydrase I
282980
-
human carbonic anhydrase II
human carbonic anhydrase III
human carbonic anhydrase isoenzyme I
247
-
human carbonic anhydrase isoenzyme II
247
-
human carbonic anhydrase IX
247
-
human carbonic anhydrase XII
279095
-
human carbonic anhydrase XIV
279094
-
isozyme CA II
279095
-
isozyme CA IV
279095
-
Membrane antigen MN
-
-
-
-
mesohalophilic carbonic anhydrase
282976
-
P54/58N
-
-
-
-
pMW1
-
-
-
-
poly-[Hb-SOD-CAT-CA]
247
-
polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase
247
-
RCC-associated antigen G250
-
-
-
-
Renal cell carcinoma-associated antigen G250
-
-
-
-
Salivary carbonic anhydrase
Secreted carbonic anhydrase
Tumor antigen HOM-RCC-3.1.3
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
H2CO3 = CO2 + H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
-
-
addition
-
-
-
-
hydration
dehydration
SYSTEMATIC NAME
IUBMB Comments
carbonic acid hydro-lyase (carbon-dioxide-forming)
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-03-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
-
-
-
?
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
show the reaction diagram
-
-
-
?
4-nitrophenyl sulfate + H2O
4-nitrophenol + sulfate
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
strongly activating effect, Mg2+ induces an increase in the kcat/Km value
Mn2+
strongly activating effect, Mn2+ induces an increase in the kcat/Km value
Na+
a key role for sodium ions in increasing halotolerant enzyme stability largely through interactions with the highly ordered first Na+ hydration shell, molecular dynamics calculations, overview. Very strong activation by Na2SO4 of all enzymes, especially of mutant M4, slight activation by NaCl, overview
Ni2+
-
-
additional information
distribution of cations and anions within 3 A of the enzyme surface, overview
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
isoenzyme hCA VI
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
isoenzyme hCA VI
2-aminobenzenesulfonamide
-
2-hydrazinobenzenesulfonamide
-
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
isoenzyme hCA VI
4,5-dichloro-benzene-1,3-disulfonamide
isoenzyme hCA VI, i.e. daranide
4-(2-aminoethyl)benzenesulfonamide
-
4-(2-hydroxyethyl)benzenesulfonamide
-
4-(aminomethyl)benzenesulfonamide
-
4-(aminosulfonyl)benzoic acid
-
4-(hydroxymethyl)benzenesulfonamide
-
4-amino-3-bromobenzenesulfonamide
-
4-amino-3-chlorobenzenesulfonamide
-
4-amino-3-fluorobenzenesulfonamide
-
4-amino-3-iodobenzenesulfonamide
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
4-Aminobenzenesulfonamide
-
4-hydrazinobenzenesulfonamide
-
4-methylbenzenesulfonamide
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
6-chloro-4-amino-benzene-1,3-disulfonamide
isoenzyme hCA VI
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
isoenzyme hCA VI
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
isoenzyme hCA VI
acetazolamide
benzolamide
-
brinzolamide
dichlorophenamide
-
dorzolamide
ethoxzolamide
hydrochlorothiazide
isoenzyme hCA VI
indisulam
-
methazolamide
-
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
isoenzyme hCA VI
sulpiride
-
topiramate
(2,4,6-triisopropylphenyl)sulfonylsulfamic acid
-
-
(2,4,6-tripropylphenyl)sulfonylsulfamic acid
-
-
(2,5-dichlorophenyl)sulfonylsulfamic acid
-
-
(2-nitrophenyl)sulfonylsulfamic acid
-
-
(2E)-2-[(4-hydroxy-3-methylphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide
-
(2E)-2-[(4-hydroxyphenyl)methylidene]-N-(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)hydrazine-1-carboxamide
-
(2E)-4-methoxy-4-oxobut-2-enoic acid
-
-
(2E)-but-2-enedioic acid
-
-
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(3,5-dichloro-2-hydroxyphenyl)sulfonylsulfamic acid
-
-
(3-chloro-4-hydroxyphenyl)acetic acid
-
-
(3-chloro-4-nitrophenyl)sulfonylsulfamic acid
-
-
(3-chlorophenyl)acetic acid
-
-
(3-nitrophenyl)sulfonylsulfamic acid
-
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate
-
-
(4-acetylphenyl)sulfonylsulfamic acid
-
-
(4-bromophenyl)sulfonylsulfamic acid
-
-
(4-chlorophenyl)sulfonylsulfamic acid
-
-
(4-fluorophenyl)sulfonylsulfamic acid
-
-
(4-hydroxyphenyl)acetic acid
-
-
(4-iodophenyl)sulfonylsulfamic acid
-
-
(4-methoxyphenyl)sulfonylsulfamic acid
-
-
(4-methylphenyl)sulfonylsulfamic acid
-
-
(4-nitrophenyl)sulfonylsulfamic acid
-
-
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(heptadecafluorooctyl)sulfonylsulfamic acid
-
-
(nonafluorobutyl)sulfonylsulfamic acid
-
-
(pentafluorophenyl)sulfonylsulfamic acid
-
-
(R)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one
-
(R)-17(R)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(R)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide
-
(R)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(R)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(R)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(R)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
(R)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)- 4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)- 4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-1-[4-(benzenesulfonyl)-2-benzylpiperazin-1-yl]ethan-1-one
-
(S)-2-(2-ammoniopropanamido)-4-methylbenzo[d]thiazol-3-ium di-2,2,2-trifluoroacetate
-
(S)-4-(2,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide
-
(S)-4-(2-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(2-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(3,4-dibenzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(3-benzyl-4-methanesulfonylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(3-benzyl-4-methylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(4-acetyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(4-benzoyl-2-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-(4-benzoyl-3-benzylpiperazine-1-carbonyl)benzene-1-sulfonamide
-
(S)-4-[2-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)-4-[2-benzyl-4-(4-sulfamoylbenzoyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)-4-[3-benzyl-4-(2-phenylacetyl)piperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)-4-[4-(benzenesulfonyl)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)-4-[4-(benzenesulfonyl)-3-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
(S)-benzyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxopropan-2-yl)carbamate
-
(S)-benzyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate
-
(S)-tert-butyl (1-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
-
(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
-
(S)-tert-butyl (1-((4-methylbenzo[d]thiazol-2-yl)amino)-1-oxopropan-2-yl)carbamate
-
(S)-tert-butyl (1-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
-
(trichloromethyl)sulfonylsulfamic acid
-
-
(trifluoromethyl)sulfonylsulfamic acid
-
-
1,1,1-trifluoromethanesulfonamide
-
1,1,2,2,3,3,4,4 octafluoro-n-butane-1-4-bissulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-n-hexane-1-sulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-n-heptane-1-sulfonamide
-
-
1,1-dimethyl-4-(7-sulfamoyl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazol-3-yl)piperazin-1-ium iodide
-
1,2,4-trimethoxybenzene
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)-ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane
-
-
1,2-dimethoxybenzene
-
-
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate
-
-
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate
-
-
1,3-dimethylpyrimidine-2,4(1H,3H)-dione
1,3-dioxolan-2-yl-N-(2-propenyl)-2-thiophene-sulfonamide
-
-
1,4-dimethoxybenzene
-
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
-
1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol
ID-8
1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
1-cyclopentyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
1-cyclopropyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
1-n-butyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
1-naphthylsulfonylsulfamic acid
-
-
1-[(2-oxo-2H-chromen-6-yl)methyl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane
-
1-[2-(1H-imidazol-5-yl)ethyl]-4-methyl-2,6-di(propan-2-yl)pyridin-1-ium hexafluorophosphate
-
1H,1H,2H,2H-perfluorodecyl sulfamate
-
-
1H,1H,2H,2H-perfluorooctyl sulfamate
-
-
1H,1H-perfluoroethyl sulfamate
-
-
1H-perfluoroisopropyl sulfamate
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine
-
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
2,3,5,6-tetrafluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide
-
2,3,6-trifluoro-4-(2-hydroxyethanesulfonyl)-5-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]benzene-1-sulfonamide
-
2,4,6-trichlorophenyl sulfamate
-
-
2,6-dimethoxybenzoic acid
-
-
2-(1-methylethyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(1-methylethyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3,4-dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
2-(3-hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-hydroxypropyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
2-(4-hydroxyphenyl)acetamide
-
-
2-(benzenesulfonamido-N-benzyl)-5-[N,Ndibenzylsulfonamido]-l,3,4-thiadiazole
-
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
2-(p-toluenesulfonamido)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(phenylethynyl)benzenesulfonamide
-
-
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate
-
-
2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide
-
-
2-aminobenzenesulfonamide
-
2-benzene-sulfonamido-l,3,4-thiadiazole-5-sulfonamide
-
-
2-coumaric acid
-
2-cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-cyclopropylmethyl-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-hydroxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-hydrazinobenzenesulfonamide
-
2-hydroxycinnamic acid
-
-
2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-methyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)-amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Met
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Val
-
-
2-naphthyl sulfamate
-
-
2-naphthylsulfamate
-
-
2-naphthylsulfonylsulfamic acid
-
-
2-nitrobenzenesulfonamide
-
-
2-Nitrophenol
-
product inhibition
2-oxo-2H-chromene-3-carboxylic acid
-
2-oxo-2H-thiochromene-3-carboxylic acid
-
2-phenylethyl sulfamate
-
-
2-propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(4-morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(p-toluenesulfonamido)-N-methyl]-5-[N,N-dimethylsulfonamide]-l,3,4-thiadiazole
-
-
2-[2-(4-morpholinyl)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-(acetoxy)ethyl]-N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-(propylamino)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-[4-acetyl-(1-piperazinyl)]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-[bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[benzenesulfonamido-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2H-chromen-2-one
-
3,3,4,4,5,5,6,6,6-nonafluoro-n-hexanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-n-octanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-n-decanesulfonamide
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine
-
-
3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
3,4-dihydroxybenzoic acid
-
-
3,4-dimethoxybenzoic acid
-
-
3,5-dibromo-2-(1,3-dioxalan-2-yl)-thiophene
-
-
3,5-Dihydroxybenzoic acid
-
-
3-(1,3-dioxolan-2-yl)-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(4-(4-morpholinyl)phenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide
-
-
3-(4-methylpiperazin-1-yl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(benzylamino)-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide
-
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(methylsulfonyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(phenylethynyl)benzenesulfonamide
-
-
3-(phenylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-3-(1,3-dioxolan-2-yl)-N-(1-methylethyl)-2-thiophene-sulfonamide
-
-
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-chloropropyl sulfamate
-
-
3-Hydroxybenzoic acid
-
-
3-hydroxymethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-hydroxymethyl-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-methylphenylsulfamate
-
-
3-methylsalicylic acid
-
noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-phenylprop-2-ene-1-sulfonamide
-
-
3-phenylpropanenitrile
-
-
3-tributylgermylpropanamine
-
-
3-triethylgermylpropanamine
-
-
3-triethylsilylpropanamine
-
-
3-triphenylgermylpropanamine
-
-
3-[(1-imidazolyl)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
3-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(4-morpholinyl)methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(anilinocarbonyl)amino]benzenesulfonamide
-
3-[(cyclopropylamino)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(sulfoamino)sulfonyl]benzoic acid
-
-
3-[1,3-dioxolan-2-yl]-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
-
3-[1,3-dioxolan-2-yl]-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-bromopropane
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-propylsulfonic acid sodium salt
-
-
3-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide
-
3-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-2,5,6-trifluoro-4-(2-phenylethanesulfonyl)benzene-1-sulfonamide
-
3-[[(3,4-dimethoxyphenyl)methyl]amino]-2,5,6-trifluoro-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide
-
3-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
3-[[bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-methylamino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3alpha,12alpha-diacetoxy-5beta-cholan-24-oic acid
-
-
3alpha,7alpha,12alpha-triacetoxy-5beta-cholan-24-oic acid
-
-
3alpha-acetoxy-5beta-cholan-24-oic acid
-
-
4,4'-thiodipyridine-3-sulfonamide
-
-
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)
-
-
4,5-dichloro-benzene-1,3-disulfonamide
4,5-dichlorobenzene-1,3-disulfonamide
-
-
4,6-dinitrosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-(1,3,4-thiadiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(1-methyl-5-tetrazolylthio)pyridine-3-sulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
4-(2-hydroxyethyl)benzenesulfonamide
4-(2-hydroxyethyl)phenol
-
-
4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide
-
-
4-(2-methylphenyl)benzene-1-sulfonamide
-
4-(2-phenylacetamido)-3-bromobenzenesulfonamide
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide
4-(2-phenylacetamido)benzenesulfonamide
4-(2-phenylacetamidoethyl)benzenesulfonamide
4-(2-phenylacetamidomethyl)benzenesulfonamide
4-(2-propynylthio)pyridine-3-sulfonamide
-
-
4-(2-pyridin-2-ylacetamido)benzenesulfonamide
4-(2-pyridin-4-ylacetamido)benzenesulfonamide
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide
4-(3-formylphenyl)benzene-1-sulfonamide
-
4-(3-quinolinyl)benzene-1-sulfonamide
-
4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide
-
-
4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4-cyanophenoxy)-3-pyridinesulfonamide
-
-
4-(4-fluorophenoxy)-3-pyridinesulfonamide
-
-
4-(5-methyl-2-pyrazolino)-3-pyridinesulfonamide
-
-
4-(6-nitrobenzothiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(allylamino)-3-pyridinesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
-
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
4-(aminosulfonyl)benzoic acid
-
4-(carbamoylmethylthio)pyridine-3-sulfonamide
-
-
4-(cyanomethylthio)pyridine-3-sulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
4-(methylhydrazino)-3-pyridinesulfonamide
-
-
4-(N-oxide-2-pyridylthio)pyridine-3-sulfonamide
-
-
4-(phenylethynyl)benzenesulfonamide
-
-
4-(quinolinoxy)-3-pyridinesulfonamide
-
-
4-acetyl-N-(aminosulfonyl)benzenesulfonamide
-
-
4-acetylamidophenyl sulfamate
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
4-amino-3-chlorobenzenesulfonamide
-
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
4-amino-3-fluorobenzenesulfonamide
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
4-amino-6-chlorobenzene-1,3-disulfonamide
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
4-Aminobenzenesulfonamide
4-aminoethylbenzenesulfonamide
-
4-aminosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-benzythiopyridine-3-sulfonamide
-
-
4-bromo-5-(1,3-dioxalan-2-yl)-N-(1,1-dimethylethyl)-thiophene-2-sulfonamide
-
-
4-bromobenzenesulfonamide
-
-
4-bromophenyl sulfamate
-
-
4-chlorobenzenesulfonamide
-
-
4-chlorophenyl sulfamate
-
best CA IX inhibitor
4-cyanophenyl sulfamate
-
-
4-ethoxy-3-pyridinesulfonamide
-
-
4-ethynylbenzenesulfonamide
-
-
4-fluorobenzenesulfonamide
-
4-hydrazino-3-pyridinesulfonamide
-
-
4-hydroxybenzenesulfonamide
-
-
4-iodobenzenesulfonamide
-
-
4-iodophenyl sulfamate
-
-
4-methoxy-3-pyridinesulfonamide
-
-
4-methoxyphenyl sulfamate
-
-
4-methylbenzenesulfonamide
-
4-methylphenyl sulfamate
-
-
4-methylthiopyridine-3-sulfonamide
-
-
4-nitrobenzenesulfonamide
-
-
4-nitrophenyl sulfamate
-
-
4-phenoxyphenyl sulfamate
-
-
4-phenylbenzene-1-sulfonamide
-
4-phenylphenyl sulfamate
-
-
4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I
4-sulfosalicylic acid
-
uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II
4-t-butylphenyl sulfamate
-
-
4-toluenesulfonamide
-
-
4-trichloromethylphenyl sulfamate
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
4-[(2R)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
4-[(2S)-2-benzylpiperazine-1-carbonyl]benzene-1-sulfonamide
-
4-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-hydroxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide
-
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
-
4-[(methylsulfonyl)amino]benzenesulfonamide
-
4-[(phenylsulfonyl)amino]benzenesulfonamide
-
4-[(sulfoamino)sulfonyl]benzoic acid
-
-
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide
4-[2-(2-thienyl)acetamido]benzenesulfonamide
4-[2-(4-sulfamoylphenyl)ethylamino]-3-pyridinosulfonamide
-
-
4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide
-
4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide
-
4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(methylsulfonyl)phenyl]-3-phenyldihydrofuran-2(3H)-one
-
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
-
4-[N'-(1,1-dioxopyrido[4,3-e]-1,4,2-dithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide
-
4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide
-
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
5,6-diamino-1,3-dimethyluracil
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide
5-(3,7,12-trioxo-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,12alpha-dihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-triacetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-acetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-hydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
5-amino-1,3,4-thiadiazole-2-sulfonamide
5-bromo-1-(4-methylbenzene-1-sulfonyl)pyrimidine-2,4(1H,3H)-dione
5-bromo-1-(methanesulfonyl)pyrimidine-2,4(1H,3H)-dione
5-chlorosalicylic acid
-
uncompetitive inhibition of isozymes carbonic anhydrase I and II
5-fluorouracil
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
5-pentylresorcinylsulfamate
-
-
5-sulfosalicylic acid
-
competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II
5-[(2-phenylethyl)(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(2,4-dichlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(2-methylpropyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(3,4,5-trimethoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(4-chlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(4-methoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(butyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(dodecyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(pentyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(propan-2-yl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide
5-[benzyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[ethyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[methyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
5-{(2,4-dichlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-bromobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-chlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-fluorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-methoxybenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-methylbenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(benzylsulfonyl)[2-(4-bromophenyl)ethyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{benzyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{butyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{dodecyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{ethyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{methyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
5-{[(4-methylphenyl)sulfonyl](2-methylpropyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](2-phenylethyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](3,4,5-trimethoxybenzyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](pentyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](propan-2-yl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](propyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[2-(4-bromophenyl)ethyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[3-(2-methoxyphenyl)propyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
6,7-dimethoxy-1-ethyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
6,7-dimethoxy-1-isopropyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
6,7-dimethoxy-1-propyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
6-((1S)-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
-
6-(aminomethyl)-2H-chromen-2-one
-
6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid
-
6-(hydroxymethyl)-2H-chromen-2-one
-
6-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
6-acetyl-7-adamantylethoxy-2H-chromen-2-one
-
-
6-acetyl-7-butoxy-2H-chromen-2-one
-
-
6-acetyl-7-ethoxy-2H-chromen-2-one
-
-
6-acetyl-7-hydroxy-2H-chromen-2-one
-
-
6-acetyl-7-methoxy-2H-chromen-2-one
-
-
6-acetyl-7-propoxy-2H-chromen-2-one
-
-
6-amino-1,3-dimethyluracil
6-amino-5-bromouracil
-
6-amino-5-chlorouracil
-
6-chloro-4-amino-benzene-1,3-disulfonamide
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
-
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
6-methyl-2-oxo-2H-chromene-3-carboxylic acid
-
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
6-methylpyrimidine-2,4(1H,3H)-dione
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
667-coumate
-
7-(2-phenylethoxy)-2H-chromen-2-one
-
7-(benzyloxy)-2H-chromen-2-one
-
7-alpha-hydroxydehydroepiandrosterone sulfamate
-
-
7-butoxy-2H-chromen-2-one
-
7-ethoxy-2H-chromen-2-one
-
7-ethoxy-8-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-6-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-8-propanoyl-2H-chromen-2-one
-
-
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
-
7-methoxy-2H-chromen-2-one
-
7-methoxy-8-propanoyl-2H-chromen-2-one
-
-
7-oxodehydroepiandrosterone sulfamate
-
-
7-propoxy-2H-chromen-2-one
-
7alpha-hydroxyepiandrosterone sulfamate
-
-
8-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
8-acetyl-7-butoxy-2H-chromen-2-one
-
-
8-acetyl-7-ethoxy-2H-chromen-2-one
-
-
8-acetyl-7-hydroxy-2H-chromen-2-one
-
-
8-acetyl-7-methoxy-2H-chromen-2-one
-
-
8-acetyl-7-propoxy-2H-chromen-2-one
-
-
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
8-propanoyl-7-propoxy-2H-chromen-2-one
-
-
acetaldehyde
-
modification of carbonic anhydrase II with acetaldehyde leads to decreased enzyme activity, acetaldehyde (100 mM) in the presence of NaBH3(CN) causes 23.7% reduction in CA II activity, in the absence of NaBH3(CN) the activity is only slightly reduced
acetazolamide
Acetylsalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
allylamine hydrochloride
-
-
allylsulfonamide
-
-
allylsulfonamide hydrochloride
-
-
allylsulfonyl chloride
-
-
ArSO2-NHPO3H2
-
-
azetazolamide
-
-
azide
best inhibitor
benzene-1,2-diol
inhibition of isozyme hCA I
benzene-1,3-diol
inhibition of isozyme hCA I
benzenesulfonamide
-
-
benzolamide
Benzyl (2-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)amino)-2-oxoethyl)carbamate
-
benzyl (2-((4-methylbenzo[d]thiazol-2-yl)amino)-2-oxoethyl)carbamate
-
benzyl (2-((6-(methylsulfonyl)benzo[d]thiazol-2-yl)amino)-2-oxoethyl)carbamate
-
benzyl sulfamate
-
-
benzylsulfonylsulfamic acid
-
-
bicarbonate
brinzolamide
but-3-enyl sulfamate
-
-
but-3-ynyl sulfamate
-
-
callistephin
-
Carbonate
best inhibitor
catechin
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
catechol
celecoxib
CF3SO2NH2
-
-
chlorazolamide
-
-
Chlorthalidone
chlorthalidone is a medium potency CA I, II, and IV inhibitor, a very effective inhibitor of CA VB, CA VII, CA IX, CA XII, and CA XIII and an ineffective inhibitor of isozymes CA III, VA, VI, and XIV
chlorzolamide
potent inhibitor
cholesteryl sulfamate
-
-
Cl-
-
relatively resistant to
coumarin
-
-
Cu-GGHSLN
time-dependent inactivation of carbonic anhydrase I activity, within 3 h carbonic anhydrase I activity is eliminated at 0.005 mM Cu-GGHSLN
-
curcumin
cyanamide
-
-
cyanide
best inhibitor
cyclohexyl sulfamate
-
-
cyclopentyl sulfamate
-
-
dehydroepiandrosterone sulfamate
dichlorophenamide
diflunisal
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
dimethylsilyl para-toluenesulfonamidoborane
-
-
dimethylsilyl-diphenylaminoborane
-
-
dimethylsilyl-N-methyl-N-phenylaminoborane
-
-
dimethylsilylaminoborane
-
-
dimethylsilylboronic acid
-
-
dimethylsilylfluoroborane
-
-
dimethylsilylsulfonamidoborane
-
-
dinitrosalicylic acid
-
-
dobutamin
dorzolamide
EMATE
-
-
EMD 486019
EMD 486019 acts as a strong inhibitor of isozymes carbonic anhydrase II, VB, VII, IX, XII, and XIV
estradiol 17 beta-sulfamate
-
-
estradiol 3,17 beta-disulfamate
estrone sulfamate
-
-
ethanol
-
-
ethoxazolamide
-
systemic carbonic anhydrase inhibitor
ethoxyzolamide
-
-
ethoxzolamide
ethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate
-
ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate
-
ethyl sulfamate
-
-
fluorenylmethyl sulfamate
-
-
fluoride
weak inhibitor
Furosemide
H2NSO2NH2
H2NSO3H
histamine
-
-
homosulfanilamide
-
hydrochlorothiazide
hydrogen sulfide
best inhibitor
hydrosulfide
-
Hydroxyurea
-
-
indapamide
indapamide is a quite ineffective inhibitor of isozymes CA I, II, III, VA, VI, and XIV, a medium potency CA IV and CA VB inhibitor, and a very effective inhibitor of isozymes CA VII, IX, XII, and XIII
indisulam
Isoorotic acid
isopropyl sulfamate
-
-
isopropylsulfonylsulfamic acid
-
-
L-adrenaline
-
-
methazolamide
methyl (3-chloro-4-hydroxyphenyl)acetate
-
-
methyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate
-
methyl N-[(2,3,4,6-Tetra-O-acetyl-beta-D-glucosyl)sulfonyl]-L-4'-sulfamoylprolinate
-
methyl N-[(2,3,4,6-tetra-O-acetyl-beta-D-glucosyl)sulfonyl]-L-sulfamoylserinate
-
methyl sulfamate
-
-
methylbenzolamide
-
-
methylsulfonylsulfamic acid
-
-
N'',N'''-bis[(E)-(2,3,4-trihydroxyphenyl)methylidene]carbonic dihydrazide
-
N'',N'''-bis[(E)-(2,3-dihydroxyphenyl)methylidene]carbonic dihydrazide
-
N'',N'''-bis[(E)-(2,4,6-trihydroxyphenyl)methylidene]carbonic dihydrazide
-
N'',N'''-Bis[(E)-(2,4-dichlorophenyl)methylidene]carbonic dihydrazide
-
N'',N'''-bis[(E)-(2,5-dihydroxyphenyl)methylidene]carbonic dihydrazide
-
N'',N'''-bis[(E)-(2,6-dichlorophenyl)methylidene]carbonic dihydrazide
mixed-type inhibition
N'',N'''-bis[(E)-(2-bromophenyl)methylidene]carbonic dihydrazide
-
N'',N'''-bis[(E)-(2-chloro-5-nitrophenyl)methylidene]carbonic dihydrazide
mixed-type inhibition
N'',N'''-bis[(E)-(2-chlorophenyl)methylidene]carbonic dihydrazide