Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Homo sapiens and UniProt Accession P00915

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This record set is specific for:
Homo sapiens
UNIPROT: P00915


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea


The taxonomic range for the selected organisms is: Homo sapiens

EC NUMBER
COMMENTARY hide
4.2.1.1
-
RECOMMENDED NAME
GeneOntology No.
carbonic anhydrase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
H2CO3 = CO2 + H2O
show the reaction diagram
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-hydroxypropanoate cycle
-
-
3-hydroxypropanoate/4-hydroxybutanate cycle
-
-
C4 photosynthetic carbon assimilation cycle, NAD-ME type
-
-
C4 photosynthetic carbon assimilation cycle, NADP-ME type
-
-
C4 photosynthetic carbon assimilation cycle, PEPCK type
-
-
CO2 fixation into oxaloacetate (anaplerotic)
-
-
cyanate degradation
-
-
gluconeogenesis II (Methanobacterium thermoautotrophicum)
-
-
glyoxylate assimilation
-
-
cyanate degradation
-
-
Nitrogen metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
carbonic acid hydro-lyase (carbon-dioxide-forming)
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-03-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
isozyme CAIX expression and activity is associated with metabolic dysfunction in MDA-MB-231 cells
physiological function
additional information
-
EGF induces CAIX translocation to lipid rafts but not its phosphorylation
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
show the reaction diagram
-
-
-
?
3-nitrophenyl acetate + H2O
3-nitrophenol + acetate
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + ?
show the reaction diagram
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
show the reaction diagram
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl propionate + H2O
4-nitrophenol + propionate
show the reaction diagram
-
-
-
?
4-nitrophenyl sulfate + H2O
4-nitrophenol + sulfate
show the reaction diagram
-
-
-
-
?
CO2 + H2O
H2CO3
show the reaction diagram
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CO2 + H2O
H2CO3
show the reaction diagram
H2CO3
CO2 + H2O
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
strongly activating effect, Mg2+ induces an increase in the kcat/Km value
Mn2+
-
strongly activating effect, Mn2+ induces an increase in the kcat/Km value
Ni2+
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
-
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
isoenzyme hCA I
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
-
isoenzyme hCA I
4,5-dichloro-benzene-1,3-disulfonamide
-
isoenzyme hCA I, i.e. daranide
6-chloro-4-amino-benzene-1,3-disulfonamide
-
isoenzyme hCA I
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
-
isoenzyme hCA I
acetazolamide
-
isoenzyme hCA I
brinzolamide
isoenzyme hCA I
dorzolamide
isoenzyme hCA I
ethoxzolamide
-
isoenzyme hCA I
Furosemide
-
isoenzyme hCA I
H2NSO2NH2
-
isoenzyme hCA I
H2NSO3H
-
isoenzyme hCA I
hydrochlorothiazide
-
isoenzyme hCA I
N-hydroxysulfamide
-
isoenzyme hCA I
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
-
SO42-
-
isoenzyme hCA I
sulthiame
-
isoenzyme hCA I
topiramate
-
isoenzyme hCA I
zonisamide
isoenzyme hCA I
(2,4,6-triisopropylphenyl)sulfonylsulfamic acid
-
-
(2,4,6-tripropylphenyl)sulfonylsulfamic acid
-
-
(2,5-dichlorophenyl)sulfonylsulfamic acid
-
-
(2-nitrophenyl)sulfonylsulfamic acid
-
-
(2E)-4-methoxy-4-oxobut-2-enoic acid
-
-
(2E)-but-2-enedioic acid
-
-
(2R)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(2S)-3-(3-chloro-4-hydroxyphenyl)-2-[[(2E)-4-methoxy-4-oxobut-2-enoyl]amino]propanoic acid
-
-
(3,5-dichloro-2-hydroxyphenyl)sulfonylsulfamic acid
-
-
(3-chloro-4-hydroxyphenyl)acetic acid
-
-
(3-chloro-4-nitrophenyl)sulfonylsulfamic acid
-
-
(3-chlorophenyl)acetic acid
-
-
(3-nitrophenyl)sulfonylsulfamic acid
-
-
(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl sulfamate
-
-
(4-acetylphenyl)sulfonylsulfamic acid
-
-
(4-bromophenyl)sulfonylsulfamic acid
-
-
(4-chlorophenyl)sulfonylsulfamic acid
-
-
(4-fluorophenyl)sulfonylsulfamic acid
-
-
(4-hydroxyphenyl)acetic acid
-
-
(4-iodophenyl)sulfonylsulfamic acid
-
-
(4-methoxyphenyl)sulfonylsulfamic acid
-
-
(4-methylphenyl)sulfonylsulfamic acid
-
-
(4-nitrophenyl)sulfonylsulfamic acid
-
-
(5Z)-2-amino-5-(3,4-dihydroxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(5Z)-2-amino-5-(4-hydroxy-3-methoxybenzylidene)-3,5-dihydro-4H-imidazol-4-one
-
-
(heptadecafluorooctyl)sulfonylsulfamic acid
-
-
(nonafluorobutyl)sulfonylsulfamic acid
-
-
(pentafluorophenyl)sulfonylsulfamic acid
-
-
(trichloromethyl)sulfonylsulfamic acid
-
-
(trifluoromethyl)sulfonylsulfamic acid
-
-
1,1,1-trifluoromethanesulfonamide
-
1,1,2,2,3,3,4,4 octafluoro-n-butane-1-4-bissulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,6-tridecafluoro-n-hexane-1-sulfonamide
-
-
1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-n-heptane-1-sulfonamide
-
-
1,1-dimethyl-4-(7-sulfamoyl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazol-3-yl)piperazin-1-ium iodide
-
1,2,4-trimethoxybenzene
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)-ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane
-
-
1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane
-
-
1,2-dimethoxybenzene
-
-
1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose 6-sulfamate
-
-
1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose 3-sulfamate
-
-
1,3-dioxolan-2-yl-N-(2-propenyl)-2-thiophene-sulfonamide
-
-
1,4-dimethoxybenzene
-
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
-
1-cyclohexyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
1-cyclopentyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
1-cyclopropyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
1-n-butyl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
1-naphthylsulfonylsulfamic acid
-
-
1-[(2-oxo-2H-chromen-6-yl)methyl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane
-
-
1H,1H,2H,2H-perfluorodecyl sulfamate
-
-
1H,1H,2H,2H-perfluorooctyl sulfamate
-
-
1H,1H-perfluoroethyl sulfamate
-
-
1H-perfluoroisopropyl sulfamate
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-galactopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-glucopyranosylamine
-
-
2,3,4,6-tetra-O-acetyl-N-sulfamoyl-beta-D-mannopyranosylamine
-
-
2,3,4-tri-O-acetyl-6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
2,4,6-trichlorophenyl sulfamate
-
-
2,6-dimethoxybenzoic acid
-
-
2-(1-methylethyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(1-methylethyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(2-methoxyethyl)-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3,4-dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-methoxyethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-(2-phenylethyl)acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(3-methoxyphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide
-
-
2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
2-(3-hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-hydroxypropyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-(3-methoxypropyl)-4-(methylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
2-(4-hydroxyphenyl)acetamide
-
-
2-(benzenesulfonamido-N-benzyl)-5-[N,Ndibenzylsulfonamido]-l,3,4-thiadiazole
-
-
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
2-(p-toluenesulfonamido)-l,3,4-thiadiazole-5-sulfonamide
-
-
2-(phenylethynyl)benzenesulfonamide
-
-
2-adamantylethyl 7-methoxy-2-oxo-2H-chromene-8-carboxylate
-
-
2-amino-1-benzothiophen-3(2H)-one 1,1-dioxide
-
-
2-aminobenzenesulfonamide
-
-
2-benzene-sulfonamido-l,3,4-thiadiazole-5-sulfonamide
-
-
2-cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-cyclopropylmethyl-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-hydroxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-hydrazinobenzenesulfonamide
-
-
2-hydroxycinnamic acid
-
-
2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-methyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-methyl-3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)-amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ala
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Asn
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Gln
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Ile
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Leu
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Met
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Phe
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Pro
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Trp
-
-
2-N-(4-sulfamoylphenyl)-thioformyl-L-Val
-
-
2-naphthyl sulfamate
-
-
2-naphthylsulfamate
-
-
2-naphthylsulfonylsulfamic acid
-
-
2-nitrobenzenesulfonamide
-
-
2-Nitrophenol
-
product inhibition
2-oxo-2H-chromene-3-carboxylic acid
-
-
2-oxo-2H-thiochromene-3-carboxylic acid
-
-
2-phenylethyl sulfamate
-
-
2-propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(4-morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
2-[(p-toluenesulfonamido)-N-methyl]-5-[N,N-dimethylsulfonamide]-l,3,4-thiadiazole
-
-
2-[2-(4-morpholinyl)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-(acetoxy)ethyl]-N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-(propylamino)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[2-[4-acetyl-(1-piperazinyl)]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
2-[2-[bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
-
2-[benzenesulfonamido-N-(n-propyl)]-l,3,4-thiadiazole-5-sulfonamide
-
-
2H-chromen-2-one
-
-
3,3,4,4,5,5,6,6,6-nonafluoro-n-hexanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-n-octanesulfonamide
-
-
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-n-decanesulfonamide
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-arabino-hexopyranosylamine
-
-
3,4,6-tri-O-acetyl-2-deoxy-N-sulfamoyl-beta-D-lyxo-hexopyranosylamine
-
-
3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
3,4-dihydroxybenzoic acid
-
-
3,4-dimethoxybenzoic acid
-
-
3,5-dibromo-2-(1,3-dioxalan-2-yl)-thiophene
-
-
3,5-Dihydroxybenzoic acid
-
-
3-(1,3-dioxolan-2-yl)-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyethyl)-2-thiophenesulfonamide
-
-
-
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(3-methoxyethyl)-2-thiophenesulfonamide
-
-
-
3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-(4-(4-morpholinyl)phenyl)-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
-
-
3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide
-
-
3-(4-methylpiperazin-1-yl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(methylsulfonyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-(phenylethynyl)benzenesulfonamide
-
-
3-(phenylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-3-(1,3-dioxolan-2-yl)-N-(1-methylethyl)-2-thiophene-sulfonamide
-
-
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-chloropropyl sulfamate
-
-
3-Hydroxybenzoic acid
-
-
3-hydroxymethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-hydroxymethyl-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
3-methylphenylsulfamate
-
-
3-methylsalicylic acid
-
noncompetitive inhibition of isozyme carbonic anhydrase I and uncompetitive inhibition of isozyme carbonic anhydrase II
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
3-phenylprop-2-ene-1-sulfonamide
-
-
3-phenylpropanenitrile
-
-
3-tributylgermylpropanamine
-
-
3-triethylgermylpropanamine
-
-
3-triethylsilylpropanamine
-
-
3-triphenylgermylpropanamine
-
-
3-[(1-imidazolyl)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
3-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3-[(4-morpholinyl)methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(anilinocarbonyl)amino]benzenesulfonamide
-
3-[(cyclopropylamino)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[(sulfoamino)sulfonyl]benzoic acid
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-bromopropane
-
-
3-[9-borabicyclo[1.3.3.]nonane]-1-propylsulfonic acid sodium salt
-
-
3-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
3-[[bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
-
3-[[N-(2-methoxyethyl)-N-methylamino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
3alpha,12alpha-diacetoxy-5beta-cholan-24-oic acid
-
-
3alpha,7alpha,12alpha-triacetoxy-5beta-cholan-24-oic acid
-
-
3alpha-acetoxy-5beta-cholan-24-oic acid
-
-
4,4'-thiodipyridine-3-sulfonamide
-
-
4,4'-[(1R,2R,3S,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(1R,2S,3R,4S)-3,4-dimethylcyclobutane-1,2-diyl]bis(2-methoxyphenol)
-
-
4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)
-
-
4,5-dichloro-benzene-1,3-disulfonamide
4,5-dichlorobenzene-1,3-disulfonamide
-
-
4,6-dinitrosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-(1,3,4-thiadiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(1-methyl-5-tetrazolylthio)pyridine-3-sulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)phenol
-
-
4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide
-
-
4-(2-phenylacetamido)-3-bromobenzenesulfonamide
-
-
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide
-
-
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide
-
-
4-(2-phenylacetamido)benzenesulfonamide
-
-
4-(2-phenylacetamidoethyl)benzenesulfonamide
-
-
4-(2-phenylacetamidomethyl)benzenesulfonamide
-
-
4-(2-propynylthio)pyridine-3-sulfonamide
-
-
4-(2-pyridin-2-ylacetamido)benzenesulfonamide
-
-
4-(2-pyridin-4-ylacetamido)benzenesulfonamide
-
-
4-(2-pyridin-4-ylacetamidoethyl)benzenesulfonamide
-
-
4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide
-
-
4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide
-
-
4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide
-
-
4-(4-cyanophenoxy)-3-pyridinesulfonamide
-
-
4-(4-fluorophenoxy)-3-pyridinesulfonamide
-
-
4-(5-methyl-2-pyrazolino)-3-pyridinesulfonamide
-
-
4-(6-nitrobenzothiazol-2-ylthio)pyridine-3-sulfonamide
-
-
4-(allylamino)-3-pyridinesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
-
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
-
4-(aminosulfonyl)benzoic acid
-
-
4-(carbamoylmethylthio)pyridine-3-sulfonamide
-
-
4-(cyanomethylthio)pyridine-3-sulfonamide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-(methylhydrazino)-3-pyridinesulfonamide
-
-
4-(N-oxide-2-pyridylthio)pyridine-3-sulfonamide
-
-
4-(phenylethynyl)benzenesulfonamide
-
-
4-(quinolinoxy)-3-pyridinesulfonamide
-
-
4-acetyl-N-(aminosulfonyl)benzenesulfonamide
-
-
4-acetylamidophenyl sulfamate
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
-
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-aminoethylbenzenesulfonamide
-
4-aminosalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
4-benzythiopyridine-3-sulfonamide
-
-
4-bromo-5-(1,3-dioxalan-2-yl)-N-(1,1-dimethylethyl)-thiophene-2-sulfonamide
-
-
4-bromobenzenesulfonamide
-
-
4-bromophenyl sulfamate
-
-
4-chlorobenzenesulfonamide
-
-
4-chlorophenyl sulfamate
-
best CA IX inhibitor
4-cyanophenyl sulfamate
-
-
4-ethoxy-3-pyridinesulfonamide
-
-
4-ethynylbenzenesulfonamide
-
-
4-fluorobenzenesulfonamide
-
-
4-hydrazino-3-pyridinesulfonamide
-
-
4-hydrazinobenzenesulfonamide
-
-
4-hydroxybenzenesulfonamide
-
-
4-iodobenzenesulfonamide
-
-
4-iodophenyl sulfamate
-
-
4-methoxy-3-pyridinesulfonamide
-
-
4-methoxyphenyl sulfamate
-
-
4-methylbenzenesulfonamide
-
-
4-methylphenyl sulfamate
-
-
4-methylthiopyridine-3-sulfonamide
-
-
4-nitrobenzenesulfonamide
-
-
4-nitrophenyl sulfamate
-
-
4-phenoxyphenyl sulfamate
-
-
4-phenylphenyl sulfamate
-
-
4-S-isobutylamino-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
binds 800 times more strongly to carbonic anhydrase II than to carbonic anhydrase I
4-sulfosalicylic acid
-
uncompetitive inhibition of isozyme carbonic anhydrase I and competitive inhibition of isozyme carbonic anhydrase II
4-t-butylphenyl sulfamate
-
-
4-toluenesulfonamide
-
-
4-trichloromethylphenyl sulfamate
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
4-[(3-fluorophenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-hydroxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(3-methoxyphenyl)ethynyl]benzenesulfonamide
-
-
4-[(4-methylphenyl)ethynyl]benzenesulfonamide
-
-
4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide
-
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
-
4-[(methylsulfonyl)amino]benzenesulfonamide
-
4-[(phenylsulfonyl)amino]benzenesulfonamide
-
4-[(sulfoamino)sulfonyl]benzoic acid
-
-
4-[2-(2-thienyl)acetamidoethyl]benzenesulfonamide
-
-
4-[2-(2-thienyl)acetamidomethyl]benzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-bromobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-chlorobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]-3-fluorobenzenesulfonamide
-
-
4-[2-(2-thienyl)acetamido]benzenesulfonamide
-
-
4-[2-(4-sulfamoylphenyl)ethylamino]-3-pyridinosulfonamide
-
-
4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide
-
4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide
-
4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4',6'-tetra-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy'-3',4',6'-tri-O-acetyl-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-arabinopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(alpha-D-mannopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(beta-D-ribofuranosyl)-1H-1,2,3-triazole
-
-
4-[4-(aminosulfonyl)phenyl]-1-(hepta-O-acetyl-beta-D-maltopyranosyl)-1H-1,2,3-triazole
-
-
4-[4-(methylsulfonyl)phenyl]-3-phenyldihydrofuran-2(3H)-one
-
-
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
-
-
4-[N'-(1,1-dioxopyrido[4,3-e]-1,4,2-dithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-cyano-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[N'-(6-chloro-7-methyl-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazino]-3-pyridinesulfonamide
-
-
4-[[(aminosulfonyl)amino]sulfonyl]benzoic acid
-
-
4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide
-
4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide
-
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(2-phenylacetamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3,7,12-trioxo-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,12alpha-dihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-triacetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-acetoxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha-hydroxy-5beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(formylamino)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-chlorosalicylic acid
-
uncompetitive inhibition of isozymes carbonic anhydrase I and II
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-pentylresorcinylsulfamate
-
-
5-sulfosalicylic acid
-
competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II
5-[(2-phenylethyl)(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(2,4-dichlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(2-methylpropyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(3,4,5-trimethoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(4-chlorobenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(4-methoxybenzyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(butyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(dodecyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(pentyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(benzylsulfonyl)(propan-2-yl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[2-(2-thienyl)acetamido]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[benzyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[ethyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[methyl(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
5-{(2,4-dichlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-bromobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-chlorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-fluorobenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-methoxybenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(4-methylbenzyl)[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{(benzylsulfonyl)[2-(4-bromophenyl)ethyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{benzyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{butyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{dodecyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{ethyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{methyl[(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](2-methylpropyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](2-phenylethyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](3,4,5-trimethoxybenzyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](pentyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](propan-2-yl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[(4-methylphenyl)sulfonyl](propyl)amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[2-(4-bromophenyl)ethyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
5-{[3-(2-methoxyphenyl)propyl][(4-methylphenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
-
6,7-dimethoxy-1-ethyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
6,7-dimethoxy-1-isopropyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
6,7-dimethoxy-1-propyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide
-
-
6-((1S)-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
-
6-(1-hydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
-
-
6-(aminomethyl)-2H-chromen-2-one
-
-
6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-(hydroxymethyl)-2H-chromen-2-one
-
-
6-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
6-acetyl-7-adamantylethoxy-2H-chromen-2-one
-
-
6-acetyl-7-butoxy-2H-chromen-2-one
-
-
6-acetyl-7-ethoxy-2H-chromen-2-one
-
-
6-acetyl-7-hydroxy-2H-chromen-2-one
-
-
6-acetyl-7-methoxy-2H-chromen-2-one
-
-
6-acetyl-7-propoxy-2H-chromen-2-one
-
-
6-chloro-4-amino-benzene-1,3-disulfonamide
6-deoxy-N-sulfamoyl-alpha-L-glucopyranosylamine
-
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-methyl-2-oxo-2H-chromene-3-carboxylic acid
-
-
6-methyl-4-(methylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
6-trifluoromethyl-4-aminobenzene-1,3-disulfonamide
667-coumate
-
-
7-(2-phenylethoxy)-2H-chromen-2-one
-
-
7-(benzyloxy)-2H-chromen-2-one
-
-
7-alpha-hydroxydehydroepiandrosterone sulfamate
-
-
7-butoxy-2H-chromen-2-one
-
-
7-ethoxy-2H-chromen-2-one
-
-
7-ethoxy-8-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-1-methoxy-3-methyl-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-3-(hydroxymethyl)-1-methoxy-9-oxo-9,9a-dihydro-4aH-xanthene-8-carboxylic acid
-
-
7-hydroxy-6-propanoyl-2H-chromen-2-one
-
-
7-hydroxy-8-propanoyl-2H-chromen-2-one
-
-
7-methoxy-2-oxo-2H-chromene-4-carboxylic acid
-
-
7-methoxy-2H-chromen-2-one
-
-
7-methoxy-8-propanoyl-2H-chromen-2-one
-
-
7-oxodehydroepiandrosterone sulfamate
-
-
7-propoxy-2H-chromen-2-one
-
-
7alpha-hydroxyepiandrosterone sulfamate
-
-
8-acetyl-7-(benzyloxy)-2H-chromen-2-one
-
-
8-acetyl-7-butoxy-2H-chromen-2-one
-
-
8-acetyl-7-ethoxy-2H-chromen-2-one
-
-
8-acetyl-7-hydroxy-2H-chromen-2-one
-
-
8-acetyl-7-methoxy-2H-chromen-2-one
-
-
8-acetyl-7-propoxy-2H-chromen-2-one
-
-
8-methoxy-2-oxo-2H-chromene-3-carboxylic acid
-
-
8-propanoyl-7-propoxy-2H-chromen-2-one
-
-
acetaldehyde
-
modification of carbonic anhydrase II with acetaldehyde leads to decreased enzyme activity, acetaldehyde (100 mM) in the presence of NaBH3(CN) causes 23.7% reduction in CA II activity, in the absence of NaBH3(CN) the activity is only slightly reduced
acetazolamide
Acetylsalicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
allylamine hydrochloride
-
-
allylsulfonamide
-
-
allylsulfonamide hydrochloride
-
-
allylsulfonyl chloride
-
-
ArSO2-NHPO3H2
-
-
azetazolamide
-
-
azide
-
best inhibitor
benzenesulfonamide
-
-
benzyl sulfamate
-
-
benzylsulfonylsulfamic acid
-
-
bicarbonate
-
-
brinzolamide
bromide
-
-
but-3-enyl sulfamate
-
-
but-3-ynyl sulfamate
-
-
Carbonate
-
best inhibitor
catechin
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
celecoxib
-
-
CF3SO2NH2
-
-
chlorazolamide
-
-
chloride
-
-
Chlorthalidone
-
chlorthalidone is a medium potency CA I, II, and IV inhibitor, a very effective inhibitor of CA VB, CA VII, CA IX, CA XII, and CA XIII and an ineffective inhibitor of isozymes CA III, VA, VI, and XIV
chlorzolamide
-
potent inhibitor
cholesteryl sulfamate
-
-
Cl-
-
relatively resistant to
Cu-GGHSLN
-
time-dependent inactivation of carbonic anhydrase I activity, within 3 h carbonic anhydrase I activity is eliminated at 0.005 mM Cu-GGHSLN
-
curcumin
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
cyanamide
-
-
cyanide
-
best inhibitor
cyclohexyl sulfamate
-
-
cyclopentyl sulfamate
-
-
dehydroepiandrosterone sulfamate
dichlorophenamide
diflunisal
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
dimethylsilyl para-toluenesulfonamidoborane
-
-
dimethylsilyl-diphenylaminoborane
-
-
dimethylsilyl-N-methyl-N-phenylaminoborane
-
-
dimethylsilylaminoborane
-
-
dimethylsilylboronic acid
-
-
dimethylsilylfluoroborane
-
-
dimethylsilylsulfonamidoborane
-
-
dinitrosalicylic acid
-
-
dobutamin
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
dorzolamide
EMATE
-
-
EMD 486019
-
EMD 486019 acts as a strong inhibitor of isozymes carbonic anhydrase II, VB, VII, IX, XII, and XIV
estradiol 17 beta-sulfamate
-
-
estradiol 3,17 beta-disulfamate
-
; CA II inhibitor
estrone sulfamate
-
-
ethanol
-
-
ethoxazolamide
-
systemic carbonic anhydrase inhibitor
ethoxyzolamide
-
-
ethoxzolamide
ethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
-
ethyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate
-
-
ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate
-
-
ethyl sulfamate
-
-
fluorenylmethyl sulfamate
-
-
fluoride
-
weak inhibitor
Furosemide
H2NSO2NH2
H2NSO3H
histamine
-
-
homosulfanilamide
-
hydrochlorothiazide
hydrogen sulfide
-
best inhibitor
hydrosulfide
-
-
Hydroxyurea
-
-
indapamide
-
indapamide is a quite ineffective inhibitor of isozymes CA I, II, III, VA, VI, and XIV, a medium potency CA IV and CA VB inhibitor, and a very effective inhibitor of isozymes CA VII, IX, XII, and XIII
indisulam
isopropyl sulfamate
-
-
isopropylsulfonylsulfamic acid
-
-
L-adrenaline
-
-
methazolamide
methyl (3-chloro-4-hydroxyphenyl)acetate
-
-
methyl 6-(hydroxymethyl)-2-oxo-2H-chromene-3-carboxylate
-
-
methyl sulfamate
-
-
methylbenzolamide
-
-
methylsulfonylsulfamic acid
-
-
N,N'-biphosphoryl-4,5-dichloro-1,3-benzenesulfonamide
-
-
N,N'-bis(benzylsulfonyl)allylamine
-
-
N,N'-bis(styrenesulfonyl)allylamine
-
-
N,N-dimethylamidimidodisulfuric acid
-
-
N,N-dimethylimidodisulfuric diamide
-
-
N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(2-propylaminol)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
-
N-(1,1-dimethylethyl)-2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
-
N-(2-fluoro-4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide
-
-
N-(4-sulfamoylphenyl)-2-(thiophen-2-yl)acetamide
-
-
N-(4-[(E)-[(aminosulfonyl)imino]methyl]phenyl)acetamide
-
-
N-(4-[[(aminosulfonyl)amino]sulfonyl]phenyl)acetamide
-
-
N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide
-
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
-
-
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
-
N-(allylsulfonyl)allylamine
-
-
N-(allysulfonyl)-3-triethylsilylpropanamine
-
-
N-(aminosulfonyl)-1,1,1-trichloromethanesulfonamide
-
-
N-(aminosulfonyl)-1,1,1-trifluoromethanesulfonamide
-
-
N-(aminosulfonyl)-1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonamide
-
-
N-(aminosulfonyl)-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide
-
-
N-(aminosulfonyl)-1-(7,7-dimethylbicyclo[2.2.1]hept-1-yl)methanesulfonamide
-
-
N-(aminosulfonyl)-1-phenylmethanesulfonamide
-
-
N-(aminosulfonyl)-2,3,4,5,6-pentafluorobenzenesulfonamide
-
-
N-(aminosulfonyl)-2,4,6-triisopropylbenzenesulfonamide
-
-
N-(aminosulfonyl)-2,4,6-tripropylbenzenesulfonamide
-
-
N-(aminosulfonyl)-2,5-dichlorobenzenesulfonamide
-
-
N-(aminosulfonyl)-2-nitrobenzenesulfonamide
-
-
N-(aminosulfonyl)-3,5-dichloro-2-hydroxybenzenesulfonamide
-
-
N-(aminosulfonyl)-3-(trifluoromethyl)benzenesulfonamide
-
-
N-(aminosulfonyl)-3-chloro-4-nitrobenzenesulfonamide
-
-
N-(aminosulfonyl)-3-nitrobenzenesulfonamide
-
-
N-(aminosulfonyl)-4-bromobenzenesulfonamide
-
-
N-(aminosulfonyl)-4-chlorobenzenesulfonamide
-
-
N-(aminosulfonyl)-4-fluorobenzenesulfonamide
-
-
N-(aminosulfonyl)-4-iodobenzenesulfonamide
-
-
N-(aminosulfonyl)-4-methoxybenzenesulfonamide
-
-
N-(aminosulfonyl)-4-methylbenzenesulfonamide
-
-
N-(aminosulfonyl)-4-nitrobenzenesulfonamide
-
-
N-(aminosulfonyl)-5-(dimethylamino)naphthalene-1-sulfonamide
-
-
N-(aminosulfonyl)benzenesulfonamide
-
-
N-(aminosulfonyl)methanesulfonamide
-
-
N-(aminosulfonyl)naphthalene-1-sulfonamide
-
-
N-(aminosulfonyl)naphthalene-2-sulfonamide
-
-
N-(aminosulfonyl)propane-2-sulfonamide
-
-
N-(aminosulfonyl)quinoline-8-sulfonamide
-
-
N-(aminosulfonyl)thiophene-2-sulfonamide
-
-
N-(benzylsulfonyl)-3-tributylgermylpropanamine
-
-
N-(benzylsulfonyl)-3-triethylsilylpropanamine
-
-
N-(benzylsulfonyl)allylamine
-
-
N-(dimesilylboro)allylsulfonamide
-
-
N-(styrenesulfonyl)-3-triethylsilylpropanamine
-
-
N-(trans-styrenesulfonyl)allylamine
-
-
N-4-methoxyphenylsulfonyl-N-2-nitrobenzyl-L-alanine hydroxamate
-
-
N-4-methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate
-
-
N-allyl-1-phenylmethanesulfonamide
-
-
N-allylsulfonyl-3-[9-borabicyclo[1.3.3.]nonane]propanamine
-
-
N-benzyl-2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
n-butyl sulfamate
-
-
N-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
N-cyclohexyl-N-[(3-formyl-thien-2-yl)sulfonyl]-glycine methyl ester
-
-
N-cyclopropylmethyl-3-(1,3-dioxalan-2-yl)-2-thiophenesulfonamide
-
-
-
N-cyclopropylmethyl-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide
-
-
n-decyl sulfamate
-
; CA II inhibitor
n-dodecyl sulfamate
-
-
n-hexadecyl sulfamate
-
-
n-hexanesulfonamide
-
-
N-hydroxysulfamide
N-hydroxysulfonamide
-
-
N-n-perfluorobutylsulfonyl-alanine hydroxamate
-
-
n-octadecyl sulfamate
-
-
n-octanesulfonamide
-
-
n-octyl sulfamate
N-pentafluorophenylsulfonyl-glycine
-
-
N-pentafluorophenylsulfonyl-glycine hydroxamate
-
-
N-pentafluorophenylsulfonyl-N-4-nitrobenzyl-glycine hydroxamate
-
-
n-pentyl sulfamate
-
-
N-phosphoryl-4-carboxy-benzenesulfonamide
-
-
N-phosphoryl-6-nitro-benzothiazole-2-sulfonamide
-
-
N-phosphoryl-benzothiazole -2-sulfonamide
-
-
n-propyl sulfamate
-
-
N-salicylidene-sulfanilic acid amide
-
-
N-salicylidene-sulfanilic acid amide cobalt acetate complex
-
-
N-salicylidene-sulfanilic acid amide cobalt chloride complex
-
-
N-salicylidene-sulfanilic acid amide cobalt nitrate complex
-
-
N-salicylidene-sulfanilic acid amide cobalt sulfate complex
-
-
N-salicylidene-sulfanilic acid amide copper chloride complex
-
-
N-salicylidene-sulfanilic acid amide copper nitrate complex
-
-
N-salicylidene-sulfanilic acid amide nickel acetate complex
-
-
N-salicylidene-sulfanilic acid amide nickel chloride complex
-
-
N-salicylidene-sulfanilic acid amide nickel nitrate complex
-
-
N-salicylidene-sulfanilic acid amide nickel sulfate complex
-
-
N-sulfamoyl-beta-D-galactopyranosylamine
-
-
N-sulfamoyl-beta-D-glucopyranosylamine
-
-
N-sulfamoyl-beta-D-mannopyranosylamine
-
-
N-tert-butyl-2-(3-chloro-4-hydroxyphenyl)acetamide
-
-
n-tetradecyl sulfamate
-
; most potent CA I inhibitor
N-trimethylsilylallylsulfonamide
-
-
n-undecyl sulfamate
-
-
N-[(1E)-(1-methyl-1H-pyrrol-2-yl)methylene]sulfamide
-
-
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]sulfamide
-
-
N-[(1E)-(3-nitrophenyl)methylene]sulfamide
-
-
N-[(1E)-(4-methoxyphenyl)methylene]sulfamide
-
-
N-[(1E)-(4-methylphenyl)methylene]sulfamide
-
-
N-[(1E)-(4-nitrophenyl)methylene]sulfamide
-
-
N-[(1E)-(5-methylthien-2-yl)methylene]sulfamide
-
-
N-[(1E)-phenylmethylene]sulfamide
-
-
N-[(1E)-thien-2-ylmethylene]sulfamide
-
-
N-[(1E)-[4-(dimethylamino)phenyl]methylene]sulfamide
-
-
N-[(3-formyl-2-thienyl)sulfonyl]-glycine ethyl ester
-
-
N-[(3-formyl-thien-2-yl)sulfonyl]-N-(2-methoxyethyl)-glycine ethyl ester
-
-
N-[(3aR,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]sulfamic amide
-
-
N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide
-
N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide
-
N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide
-
N-[4-(aminosulfonyl)phenyl]acetamide
-
N-[4-(aminosulfonyl)phenyl]benzamide
-
N-[4-(aminosulfonyl)phenyl]butanamide
-
N-[4-(aminosulfonyl)phenyl]pentanamide
-
N-[4-(aminosulfonyl)phenyl]propanamide
-
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
N-[[2-(1,3-dioxalan-2-yl)-3-thienyl]sulfonyl]-N-methylglycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)-2-thienyl]sulfonyl]-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(1-methylethyl)-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(2-propenyl)-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(3-methoxyethyl)-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-ethylglycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylcyclopropyl-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylglycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-propylglycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3,4-dimethoxyphenyl)methyl]-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3-methoxyphenyl)methyl]-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(4-methoxyphenyl)methyl]-glycine ethyl ester
-
-
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[4-(morpholin-4-yl)phenyl]-glycine methyl ester
-
-
N-[[5-(aminosulfonyl)-2-formyl-thiophen-3-yl]sulfonyl]-N-methyl-glycine ethyl ester
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-alanine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-asparagine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-glutamine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-isoleucine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-leucine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-methionine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-phenylalanine
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-proline
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-tryptophan
-
-
N-[[[4-(aminosulfonyl)phenyl]amino]thioxomethyl]-L-valine
-
-
NaCl
-
weak
nitrite
-
-
OCN-
-
-
octane-1-sulfonamide
-
-
p-(aminomethyl)-benzene-sulfonamide
-
a CAII inhibitor
p-biphenylmethyl sulfamate
-
-
p-methylbenzyl sulfamate
-
-
pentachlorophenyl sulfamate
-
-
pentafluorophenyl sulfamate
-
-
perfluorobutanesulfonamide
-
-
PH2BOH
-
-
phenyl sulfamate
-
-
phenylacetonitrile
-
-
phenylarsonic acid
-
weak inhibitor
phenylboronic acid
-
weak inhibitor
phenylsulfamate
-
best CA I inhibitor
phenylsulfonylsulfamic acid
-
-
prontosil
-
-
prop-2-ene-1-sulfonamide
-
-
quinolin-8-ylsulfonylsulfamic acid
-
-
resveratrol
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
rofecoxib
-
-
RWJ-37497
-
-
saccharin
-
-
salicylic acid
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
SCN-
-
inhibits 4-nitrophenyl acetate hydrolase activity
silymarin
-
a competitive inhibitor with 4-nitrophenylacetate as substrate
SO42-
-
isoenzyme hCA XII
sodium (butylsulfonyl)azanide
-
-
sodium (hexylsulfonyl)azanide
-
-
sodium (octylsulfonyl)azanide
-
-
spermine
-
-
sulfamate
-
-
sulfamic acid
-
-
sulfanilamide
sulfasalazine
-
noncompetitive inhibition of isozymes carbonic anhydrase I and II
sulfate
-
-
sulfonamide
-
-
Sulfonamides
-
affinity of carbonic anhydrase IV for sulfonamides is decreased up to 65fold compared to carbonic anhydrase II
sulpiride
-
-
sulthiame
tert-butyl 3-[[(aminosulfonyl)amino]sulfonyl]phenylcarbamate
-
-
tert-butyl 4-[[(aminosulfonyl)amino]sulfonyl]phenylcarbamate
-
-
tert-butyl 5-[[(aminosulfonyl)amino]sulfonyl]-2-hydroperoxyphenylcarbamate
-
-
thien-2-ylsulfonylsulfamic acid
-
-
Thiocyanate
topiramate
umbelliferone
-
-
Urea
-
-
valdecoxib
-
-
zonisamide
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
-
-
[(7,7-dimethylbicyclo[2.2.1]hept-1-yl)methyl]sulfonylsulfamic acid
-
-
[3-(trifluoromethyl)phenyl]sulfonylsulfamic acid
-
-
[3-[(tert-butoxycarbonyl)amino]-4-hydroperoxyphenyl]sulfonylsulfamic acid
-
-
[3-[(tert-butoxycarbonyl)amino]phenyl]sulfonylsulfamic acid
-
-
[4-(acetylamino)phenyl]sulfonylsulfamic acid
-
-
[4-[(tert-butoxycarbonyl)amino]phenyl]sulfonylsulfamic acid
-
-
[5-(dimethylamino)-1-naphthyl]sulfonylsulfamic acid
-
-
[[(2-methylphenyl)sulfonyl]amino]carbonylsulfamic acid
-
-
[[(2-methylphenyl)sulfonyl]amino]carbonylsulfamic amide
-
-
[[(4-chlorophenyl)sulfonyl]amino]carbonylsulfamic acid
-
-
[[(4-chlorophenyl)sulfonyl]amino]carbonylsulfamic amide
-
-
[[(4-fluorophenyl)sulfonyl]amino]carbonylsulfamic acid
-
-
[[(4-fluorophenyl)sulfonyl]amino]carbonylsulfamic amide
-
-
[[(4-methylphenyl)sulfonyl]amino]carbonylsulfamic acid
-
-
[[(4-methylphenyl)sulfonyl]amino]carbonylsulfamic amide
-
-
additional information
-