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Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Stylophora pistillata and UniProt Accession B5SU02
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4.2.1.1 carbonic anhydraseIUBMB Comments
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
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- 4.2.1.1
- acetazolamide
- bicarbonate
- sulfonamide
- isozymes
- hypoxia
- glaucoma
-
intraocular
- acidosis
- epithelium
-
hypoxia-inducible
-
metalloenzyme
- endothelial
-
ocular
-
acidification
-
acid-base
- na+
- tubule
- duct
-
tumor-associated
- prostaglandin
-
diuretic
- osteoclast
-
basolateral
- gill
- rubisco
- calcification
- topiramate
-
reabsorption
-
cotransporter
-
electrolyte
-
glut-1
-
branchial
-
open-angle
-
antiepileptic
-
beta-blockers
- h+-atpase
-
acuity
- hif-1alpha
-
hypotensive
-
anticonvulsant
-
hypercapnia
- alkalosis
-
microelectrodes
- amiloride
- furosemide
-
biomineralization
- drug development
- pharmacology
- environmental protection
- diagnostics
-
cystoid
-
thiazide
- medicine
- hydrochlorothiazide
- analysis
-
glaucomatous
The taxonomic range for the selected organisms is: Stylophora pistillata
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
carbonic anhydrase, ca ix, ca ii, hca ii, hca i, carbonic anhydrase ix, carbonic anhydrase ii, hca ix, ca iv, anhydrase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
anhydrase
-
-
-
-
CA
-
-
-
-
CA-IX
-
-
-
-
CA-VA
-
-
-
-
CA-VB
-
-
-
-
CA-VI
-
-
-
-
CA-VII
-
-
-
-
CA-XII
-
-
-
-
CA-XIV
-
-
-
-
CA1
-
-
-
-
CA2
-
-
-
-
CAIX
-
-
-
-
carbonate anhydrase
-
-
-
-
Carbonate dehydratase
-
-
-
-
Carbonate dehydratase IX
-
-
-
-
Carbonate dehydratase VA
-
-
-
-
Carbonate dehydratase VB
-
-
-
-
Carbonate dehydratase VI
-
-
-
-
Carbonate dehydratase VII
-
-
-
-
Carbonate dehydratase XII
-
-
-
-
Carbonate dehydratase XIV
-
-
-
-
carbonic acid anhydrase
-
-
-
-
carbonic anhydrase
carbonic dehydratase
-
-
-
-
carboxyanhydrase
-
-
-
-
dehydratase, carbonate
-
-
-
-
Membrane antigen MN
-
-
-
-
P54/58N
-
-
-
-
pMW1
-
-
-
-
RCC-associated antigen G250
-
-
-
-
Renal cell carcinoma-associated antigen G250
-
-
-
-
Salivary carbonic anhydrase
-
-
-
-
Secreted carbonic anhydrase
-
-
-
-
Tumor antigen HOM-RCC-3.1.3
-
-
-
-
carbonic anhydrase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
-
-
-
-
addition
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
-, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
carbonic acid hydro-lyase (carbon-dioxide-forming)
The enzyme catalyses the reversible hydration of gaseous CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. Three distinct classes exist, and appear to have evolved independently. Contains zinc.
CAS REGISTRY NUMBER
COMMENTARY
9001-03-0
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
acetazolamide
highly inhibited by acetazolamide, i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl sulfamate
-
-
(6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
4-(ethylamino)-6-(3-methoxypropyl)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
the carbonic anhydrase gene is expressed 2fold more during the dark than the light
-
additional information
-
the carbonic anhydrase gene is expressed 2fold more during the dark than the light
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00251
2-hydrazinylbenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000256
3-(4-sulfamoylphenyl)propanoic acid
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00077
4-(2-hydroxyethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000768
4-(hydroxymethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00054
4-amino-3,5-dibromobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000695
4-amino-3,5-diiodobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000104
4-amino-3-bromobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000883
4-amino-3-iodobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000902
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
isozyme STPCA, pH 7.5, 20°C
0.000607
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000661
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000701
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000204
benzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.96
Br-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0000482
brinzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000342
celecoxib
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.53
Cl-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.86
CN-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.69
CNO-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.24
CO32-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.000431
dichlorophenamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000181
dorzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000394
ethoxzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.92
F-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0057
H2NSO2NH2
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0085
H2NSO3H
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
7.81
HCO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
3.94
HS-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.43
HSO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
33
I-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.000163
indisulam
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000212
methazolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
4.68
N3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
3.15
NO2-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.99
NO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0672
Ph-AsO3H2
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0081
phenyl-boronic acid
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0000403
saccharin
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.51
SCN-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.33
SO42-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.00043
sulpiride
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000452
sulthiame
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000291
topiramate
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000287
valdecoxib
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.000259
zonisamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000943
4-(2-aminoethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000577
4-(2-aminoethyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000825
4-(aminomethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000508
4-(aminomethyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000875
4-amino-3-chlorobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000551
4-amino-3-chlorobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000751
4-amino-3-fluorobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000493
4-amino-3-fluorobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000367
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000481
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000295
4-amino-6-chlorobenzene-1,3-disulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00084
4-amino-6-chlorobenzene-1,3-disulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000298
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000868
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000197
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00065
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000254
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000642
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000105
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000361
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000919
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000357
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000276
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000333
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000016
acetazolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). B5SU02_STYPI
323
0
36650
TrEMBL
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Allemand, D.; Tambutte, S.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions
Bioorg. Med. Chem. Lett.
19
650-653
2009
Stylophora pistillata
Moya, A.; Tambutte, S.; Bertucci, A.; Tambutte, E.; Lotto, S.; Vullo, D.; Supuran, C.T.; Allemand, D.; Zoccola, D.
Carbonic anhydrase in the scleractinian coral Stylophora pistillata: characterization, localization, and role in biomineralization
J. Biol. Chem.
283
25475-25484
2008
Stylophora pistillata (B5SU02), Stylophora pistillata
Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Tambutte, S.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides
Bioorg. Med. Chem.
17
5054-5058
2009
Stylophora pistillata
Bertucci, A.; Zoccola, D.; Tambutte, S.; Vullo, D.; Supuran, C.T.
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines
Bioorg. Med. Chem.
18
2300-2303
2010
Stylophora pistillata
Bertucci, A.; Innocenti, A.; Scozzafava, A.; Tambutte, S.; Zoccola, D.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata
Bioorg. Med. Chem. Lett.
21
710-714
2011
Stylophora pistillata
EXTERNAL LINKS (specific for EC-Number 4.2.1.1)
Transporter Classification Database (TCDB): 8.A.164.1.1, 2.A.53.3.12
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