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IUBMB Comments The enzyme participates in alternative menaquinone biosynthesis pathways known as the futalosine and modified futalosine pathways, which occurs in some bacterial species including several human pathogens such as Helicobacter pylori , Campylobacter jejuni , and Chlamydia .
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms 1,4-dihydroxy-6-naphthoate synthase, mqnD , SCO4326, TTHA1568, more
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1,4-dihydroxy-6-naphthoate synthase
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incorrect
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mqnD
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TTHA1568
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cyclic dehypoxanthine futalosine = 5,8-dihydroxy-2-naphthoate + dihydroxyacetone
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cyclic dehypoxanthine futalosine lyase (dihydroxyacetone-forming)
The enzyme participates in alternative menaquinone biosynthesis pathways known as the futalosine and modified futalosine pathways, which occurs in some bacterial species including several human pathogens such as Helicobacter pylori, Campylobacter jejuni, and Chlamydia.
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cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
cyclic dehypoxanthine futalosine
5,8-dihydroxy-2-naphthoate + dihydroxyacetone
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Substrates: - Products: -
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cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
Substrates: - Products: -
?
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
Substrates: - Products: -
?
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
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Substrates: - Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
cyclic dehypoxanthine futalosine
5,8-dihydroxy-2-naphthoate + dihydroxyacetone
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Substrates: - Products: -
?
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
Substrates: - Products: -
?
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
Substrates: - Products: -
?
cyclic dehypoxanthine futalosine
1,4-dihydroxy-6-naphthoate + dihydroxyacetone
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Substrates: - Products: -
?
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SwissProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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hanging drop vapor diffusion method, using 0.1 M Tris-HCl buffer (pH 7.5-8.0) containing 0.8 M potassium sodium tartrate and 0.75-2.5% (w/v) polyethylene glycol monomethyl ether 5000
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HiTrapQ column chromatography, HiTrap Butyl column chromatography, Resource Q column chromatography, and Superdex 75 gel filtration
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expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli BL21(DE3) cells
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Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.
An alternative menaquinone biosynthetic pathway operating in microorganisms
Science
321
1670-1673
2008
Streptomyces coelicolor (Q9KXN1), Thermus thermophilus
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Manion-Sommerhalter, H.R.; Fedoseyenko, D.; Joshi, S.; Begley, T.P.
Menaquinone biosynthesis The mechanism of 5,8-dihydroxy-2-naphthoate synthase (MqnD)
Biochemistry
60
1947-1951
2021
Halalkalibacterium halodurans
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Arai, R.; Murayama, K.; Uchikubo-Kamo, T.; Nishimoto, M.; Toyama, M.; Kuramitsu, S.; Terada, T.; Shirouzu, M.; Yokoyama, S.
Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8
J. Struct. Biol.
168
575-581
2009
Thermus thermophilus (Q5SI12)
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