Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 4.1.99.26 - 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase

for references in articles please use BRENDA:EC4.1.99.26

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This is a bifunctional radical AdoMet (radical SAM) enzyme that catalyses the first two steps in the biosynthesis of the enzyme cofactor mycofactocin. Activity requires the presence of the MftB chaperone. The reaction occurs in the right-to-left direction. The other activity of the enzyme is EC 1.3.98.7, [mycofactocin precursor peptide]-tyrosine decarboxylase.

The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one
+
+
+
=
C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol
+
+

Synonyms
mftC, MtfC, mycofactocin biosynthetic protein, mycofactocin maturase, mycofactocin-biosynthetic radical S-adenosylmethionine protein, Rv0693, [mycofactocin precursor peptide]-pyrrolidinone derivative synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
C-terminal [mycofactocin precursor peptide]-glycyl-3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one + 5'-deoxyadenosine + L-methionine + A = C-terminal [mycofactocin precursor peptide]-glycyl-L-valyl-4-[2-aminoethenyl]phenol + S-adenosyl-L-methionine + AH2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links