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Information on EC 4.1.99.19 - 2-iminoacetate synthase

for references in articles please use BRENDA:EC4.1.99.19

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IUBMB Comments

Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. The reductant is assumed to be NADPH, which is provided by a flavoprotein:NADPH oxidoreductase system . Part of the pathway for thiamine biosynthesis.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
thiH, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
thiazole component of thiamine diphosphate biosynthesis I
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