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Information on EC 4.1.99.12 - 3,4-dihydroxy-2-butanone-4-phosphate synthase

for references in articles please use BRENDA:EC4.1.99.12

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IUBMB Comments

Requires a divalent cation, preferably Mg2+, for activity . The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5 . The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin .

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
dbps, dhbps, 3,4-dihydroxy-2-butanone-4-phosphate synthase, mtb-dhbps, mtb-riba2, atriba1, dhbp synthase, dihydroxybutanone phosphate synthase, atriba2, vdhbps, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
flavin biosynthesis I (bacteria and plants), flavin biosynthesis II (archaea), flavin biosynthesis III (fungi)