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Information on EC 4.1.3.6 - citrate (pro-3S)-lyase
for references in articles please use BRENDA:EC4.1.3.6
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IUBMB Comments
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
- 4.1.3.6
-
pro-3s-lyase
-
klebsiella
- aerogenes
-
prosthetic
- diacetilactis
- acp
-
lipogenesis
-
rhodopseudomonas
-
phosphodiester
- dephospho-coa
- analysis
-
atp:citrate
- lyases
- leuconostoc
- gelatinosa
- medicine
showSynonyms
citrate (pro-3s)-lyase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
citrase
-
-
-
-
citratase
citrate aldolase
-
-
-
-
citrate lyase
citrate oxaloacetate-lyase(pro-3S-COO- --> acetate)
-
-
-
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citric aldolase
-
-
-
-
citridesmolase
-
-
-
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citritase
-
-
-
-
lyase, citrate
-
-
-
-
additional information
-
can be dissociated into components, two of which are identical with ec 2.8.3.10 and ec 4.1.3. 34
citratase
-
-
-
-
citrate lyase
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
citrate = acetate + oxaloacetate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
elimination
-
-
of an oxo-acid, C-C bond cleavage
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SYSTEMATIC NAME
IUBMB Comments
citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate)
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme.
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CAS REGISTRY NUMBER
COMMENTARY
9012-83-3
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Substrates: transcription of the operon encoding the citrate lyase complex is induced by acid stress
Products: -
Products: -
?
acetate + oxaloacetate
citrate
-
Substrates: -
Products: -
Products: -
r
citrate
?
Aerobacter indologenes
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: the enzyme is involved in citrate fermentation pathway
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: regulated by concentration of intracellular L-Glu
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
Leuconostoc citrovorum
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: induced by citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Substrates: citrate fermentation pathway
Products: -
Products: -
r
citrate
acetate + oxaloacetate
-
693, 33349, 33350, 33351, 33352, 33353, 33356, 33358, 33361, 33363, 33367, 33369, 33370, 33372, 441599, 747566
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Substrates: substrate is Ca2+-citrate, not Mg2+-citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Lacticaseibacillus casei ATCC 334
Substrates: substrate is Ca2+-citrate, not Mg2+-citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Substrates: citrate fermentation pathway
Products: -
Products: -
r
citrate
acetate + oxaloacetate
-
Substrates: work opposite to the citrate synthase reaction, involved in the control of the direction of carbon flow in the citric acid cycle
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Substrates: transcription of the operon encoding the citrate lyase complex is induced by acid stress
Products: -
Products: -
?
citrate
?
Aerobacter indologenes
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: the enzyme is involved in citrate fermentation pathway
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: regulated by concentration of intracellular L-Glu
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
Leuconostoc citrovorum
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: induced by citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
?
-
Substrates: key enzyme in initiating the anaerobic utilization of citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Substrates: citrate fermentation pathway
Products: -
Products: -
r
citrate
acetate + oxaloacetate
Substrates: substrate is Ca2+-citrate, not Mg2+-citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Lacticaseibacillus casei ATCC 334
Substrates: substrate is Ca2+-citrate, not Mg2+-citrate
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
-
Substrates: -
Products: -
Products: -
?
citrate
acetate + oxaloacetate
Substrates: citrate fermentation pathway
Products: -
Products: -
r
citrate
acetate + oxaloacetate
-
Substrates: work opposite to the citrate synthase reaction, involved in the control of the direction of carbon flow in the citric acid cycle
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2'-(5''-phosphoribosyl)-3'-dephospho-coenzyme A
-
attached to the gamma subunit, i.e. apo-ACP, via a phosphodiester linkage to serine-14, CitG and CitX catalyze the initial formation of the precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA and subsequent transfer to apo-citrate lyase with removal of diphosphate
2'-(5''-phosphoribosyl)-3'-dephospho-coenzyme A
-
attached to the gamma subunit, i.e. apo-ACP, via phosphodiester linkage by CitX, resulting in the formation of holo-ACP
2'-(5''-phosphoribosyl)-3'-dephospho-coenzyme A
-
CitG and CitX catalyze the initial formation of the precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA and subsequent transfer to apo-citrate lyase with removal of diphosphate
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
required, addition of citrate before Ca2+ initially results in acidification of the cytoplasm, the Ca2+-citrate metabolic pathway as a whole does not produce a net proton electrochemical gradient
Co2+
Fe2+
Mg2+
Mn2+
Zn2+
Co2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Co2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Co2+
-
strict requirement for a divalent metal ion, Mg2+, Mn2+ or Co2+
Fe2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Fe2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Mg2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+. Mg2+ and Mn2+ are most effective
Mg2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+. Mg2+ and Mn2+ are most effective
Mg2+
-
strict requirement for a divalent metal ion, Mg2+, Mn2+ or Co2+. Mg2+ is most effective
Mg2+
-
divalent cation required: Mg2+, Zn2+, Mn2+, Co2+ or Cu2+, Mg2+ is most effective
Mn2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Mn2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Mn2+
-
cooperative, binding of Mn2+ involves a conformational change in the enzyme complex
Mn2+
-
strict requirement for a divalent metal ion, Mg2+, Mn2+ or Co2+
Zn2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
Zn2+
-
strictly dependent on the presence of a divalent metal cation: Mg2+, Mn2+, Zn2+, Fe2+ or Co2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
rate of reaction inactivation of the S. diacetilactis enzyme is about 1/10 of that of the Klebsiella aerogenes enzyme
-
additional information
-
rate of reaction inactivation of the S. diacetilactis enzyme is about 1/10 of that of the Klebsiella aerogenes enzyme
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pantothenate
-
contains 3.5 mol pantothenate per mol of enzyme in the acyl-carrier-protein gamma-subunit
phosphopantothenate
-
contains 3 mol of phosphopantothenate per mol of enzyme
L-Glu
-
addition of L-Glu is not necessary for activity and stabilization of the enzyme
phosphopantetheine
-
contains an acetyl group at its active site, the group is in thioester linkage probably on phosphopantetheine
phosphopantetheine
-
the prosthetic group probably resembles 4'-phosphopantheteine
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
<