Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 4.1.3.43 - 4-hydroxy-2-oxohexanoate aldolase

for references in articles please use BRENDA:EC4.1.3.43

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].

The enzyme appears in viruses and cellular organisms

Synonyms
tthb246, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
4-nitrotoluene degradation II, androstenedione degradation I (aerobic), toluene degradation II (aerobic) (via 4-methylcatechol)