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Information on EC 4.1.3.17 - 4-hydroxy-4-methyl-2-oxoglutarate aldolase

for references in articles please use BRENDA:EC4.1.3.17
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
IUBMB Comments
Requires a divalent metal ion . This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas straminea can also catalyse the activity of EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase, and the decarboxylation of oxaloacetate .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hmg/cha aldolase, 4-hydroxy-4-methyl-2-oxoglutarate aldolase, pyruvate aldolase, hmg aldolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate
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(2)
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0
4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
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(1)
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0
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