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Information on EC 4.1.2.8 - indole-3-glycerol-phosphate lyase

for references in articles please use BRENDA:EC4.1.2.8
reinstated 2006, had been eliminated in 1972
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.8 indole-3-glycerol-phosphate lyase
IUBMB Comments
Forms part of the defence mechanism against insects and microbial pathogens in the grass family, Gramineae, where it catalyses the first committed step in the formation of the cyclic hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (DIBOA) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) . This enzyme resembles the alpha-subunit of EC 4.2.1.20, tryptophan synthase , for which, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate is also a substrate, but, unlike tryptophan synthase, its activity is independent of the beta-subunit and free indole is released .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
tryptophan synthase alpha, tryptophan synthase alpha subunit, indole-3-glycerol phosphate lyase, indole synthase, zmtsa, os03g58300, indole-3-glycerol-phosphate lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
show the reaction diagram
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