Information on EC 4.1.2.63 - 2-hydroxyacyl-CoA lyase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.63 2-hydroxyacyl-CoA lyase
IUBMB Comments
Requires Mg2+ and thiamine diphosphate. This peroxisomal enzyme, found in animals, is involved in the alpha-oxidation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA
=
a 2-methyl-branched Cn-1-fatty aldehyde
+
a (2R)-2-hydroxy-Cn-long-chain fatty acyl-CoA
=
a Cn-1-long-chain fatty aldehyde
+
Synonyms
2-HPCL, 2-hydroxyacyl-CoA lyase, 2-hydroxyphytanoyl-CoA lyase, HACL1, HPL, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2R)-2-hydroxy-Cn-long-chain fatty acyl-CoA = a Cn-1-long-chain fatty aldehyde + formyl-CoA
show the reaction diagram
(2)
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a 2-hydroxy-3-methyl-Cn-fatty-acyl-CoA = a 2-methyl-branched Cn-1-fatty aldehyde + formyl-CoA
show the reaction diagram
(1)
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