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Information on EC 4.1.2.52 - 4-hydroxy-2-oxoheptanedioate aldolase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
IUBMB Comments
Requires Co2+ or Mn2+ for activity. The enzyme is also able to catalyse the aldol cleavage of 4-hydroxy-2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency. In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate. The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate .
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The expected taxonomic range for this enzyme is: Escherichia coli
Synonyms
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, HpaI, HpcH, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
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