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Information on EC 4.1.2.46 - aliphatic (R)-hydroxynitrile lyase

for references in articles please use BRENDA:EC4.1.2.46

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IUBMB Comments

The enzyme contains Zn2+ . The enzyme catalyses the stereoselective synthesis of aliphatic (R)-cyanohydrins . No activity towards mandelonitrile and 4-hydroxymandelonitrile . Natural substrates for the (R)-oxynitrilase from Linum usitatissimum are acetone and butan-2-one, which are the building blocks of the cyanogen glycosides in Linum, linamarin and lotaustralin, or linustatin and neolinustatin, respectively .

The enzyme appears in viruses and cellular organisms

Synonyms
(R)-HNL, (R)-hydroxynitrile lyase, (R)-Oxynitrilase, Acetone cyanohydrin lyase, EC 4.1.2.37, Hydroxynitrile lyase, LuHNL, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R)-2-hydroxy-2-methylbutanenitrile = cyanide + butan-2-one
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
linamarin degradation, linustatin bioactivation, lotaustralin degradation, neolinustatin bioactivation
Highest Expressing Human Cell Lines
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