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Information on EC 4.1.2.4 - deoxyribose-phosphate aldolase and Organism(s) Toxoplasma gondii and UniProt Accession A0A125YLW2

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.4 deoxyribose-phosphate aldolase
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This record set is specific for:
Toxoplasma gondii
UNIPROT: A0A125YLW2 not found.
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Word Map
The taxonomic range for the selected organisms is: Toxoplasma gondii
The enzyme appears in selected viruses and cellular organisms
Synonyms
tgdpa, deoxyriboaldolase, 2-deoxyribose-5-phosphate aldolase, 2-deoxy-d-ribose-5-phosphate aldolase, deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, deoxyribose 5-phosphate aldolase, 2-deoxy-d-ribose 5-phosphate aldolase, 2-deoxyribose 5-phosphate aldolase, tk2104, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-Deoxyribose-5-phosphate aldolase
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-
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aldolase, deoxyribo
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-
-
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CGI-26
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Deoxyriboaldolase
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-
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deoxyribose phosphate aldolase-like protein
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Deoxyribose-5-phosphate aldolase
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deoxyribose-phosphate aldolase
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DERA
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DR aldolase
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Phosphodeoxyriboaldolase
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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aldol condensation
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-
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-
PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-97-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
show the reaction diagram
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-
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
show the reaction diagram
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-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
while TgDERA mRNA expression is marginally higher in the late bradyzoite and early oocyst stages, protein expression is also present in all life cycle stages
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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Toxoplasma gondii deoxyribose phosphate aldolase-like protein interacts with actin depolymerizing factor to enhance the actin filament dynamics in the bradyzoite stage
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
31000
57000
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GST-fused protein expressed in Escherichia coli cells, determined by SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant protein
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the GST-fused protein is affinity purified by glutathione-Sepharose beads
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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into the vector pGEX-6P-2 for expression in Escherichia coli BL21DE3 pLysS cells and into pcDNA6/V5-HisA for transfection of HEK-293T cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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possible selection as a vaccine candidate. The purified recombinant protein is used to immunize rats. The antibodies obtained are used to verify in vitro expression of the enzyme. The vector pVAX1 is utilized to formulate a DNA vaccine designated as pTgDPA, which is used to evaluate the immunological changes and the level of protection against challenge with the virulent RH strain of Toxoplasma gondii. DNA vaccine, TgDPA revealed that it can induce a strong humoral as well as cellular mediated response in mice. These responses are a contribution of TH1, TH2 and TH17 type of responses. Mice immunized with TgDPA show longer survival rates than do mice in control groups
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ueno, A.; Dautu, G.; Munyaka, B.; Carmen, G.; Kobayashi, Y.; Igarashi, M.
Toxoplasma gondii: Identification and characterization of bradyzoite-specific deoxyribose phosphate aldolase-like gene (TgDPA)
Exp. Parasitol.
121
55-63
2009
Toxoplasma gondii
Manually annotated by BRENDA team
Ueno, A.; Dautu, G.; Saiki, E.; Haga, K.; Igarashi, M.
Toxoplasma gondii deoxyribose phosphate aldolase-like protein (TgDPA) interacts with actin depolymerizing factor (TgADF) to enhance the actin filament dynamics in the bradyzoite stage
Mol. Biochem. Parasitol.
173
39-42
2010
Toxoplasma gondii, Toxoplasma gondii RH
Manually annotated by BRENDA team
Tonkin, M.L.; Halavaty, A.S.; Ramaswamy, R.; Ruan, J.; Igarashi, M.; Ngo, H.M.; Boulanger, M.J.
Structural and functional divergence of the aldolase fold in Toxoplasma gondii
J. Mol. Biol.
427
840-852
2015
Toxoplasma gondii (A0A125YLW2), Toxoplasma gondii, Toxoplasma gondii ATCC 50611 (A0A125YLW2)
Manually annotated by BRENDA team
Hassan, I.A.; Wang, S.; Xu, L.; Yan, R.; Song, X.; Li, X.
DNA vaccination with a gene encoding Toxoplasma gondii deoxyribose phosphate aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Parasit. Vectors
7
431
2014
Toxoplasma gondii, Toxoplasma gondii RH
Manually annotated by BRENDA team