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Information on EC 4.1.2.27 - sphinganine-1-phosphate aldolase and Organism(s) Dictyostelium discoideum and UniProt Accession Q54RV9

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.27 sphinganine-1-phosphate aldolase
IUBMB Comments
A pyridoxal-phosphate protein.
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This record set is specific for:
Dictyostelium discoideum
UNIPROT: Q54RV9
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
s1p lyase, sgpl1, sphingosine-1-phosphate lyase, s1p-lyase, sphingosine phosphate lyase, sphingosine 1-phosphate lyase, legs2, dpl1p, s1pl2021, sphingosine-phosphate lyase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sphingosine-1-phosphate lyase
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aldolase, dihydrosphingosine 1-phosphate
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-
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Dihydrosphingosine 1-phosphate aldolase
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-
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sphinganine 1-phosphate lyase
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-
-
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sphinganine-1-phosphate aldolase
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-
-
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sphinganine-1-phosphate-alkanal-lyase
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-
-
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sphingosine-1-phosphate lyase
sphingosine-phosphate lyase
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
37290-61-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
sphingosine 1-phosphate
phosphoethanolamine + hexadecanal
show the reaction diagram
-
-
?
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
show the reaction diagram
pathway of sphingomyelin degradation, sphingosine 1-phosphate is an important element of signal transduction pathways that regulate cell proliferation and cell death
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ir
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
show the reaction diagram
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-
-
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ir
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sphingosine 1-phosphate
phosphoethanolamine + palmitaldehyde
show the reaction diagram
pathway of sphingomyelin degradation, sphingosine 1-phosphate is an important element of signal transduction pathways that regulate cell proliferation and cell death
-
ir
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
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-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SGPL_DICDI
528
1
58239
Swiss-Prot
other Location (Reliability: 2)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Li, G.; Foote, C.; Alexander, S.; Alexander, H.
Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
Development
128
3473-3483
2001
Dictyostelium discoideum (Q54RV9), Dictyostelium discoideum
Manually annotated by BRENDA team
Bandhuvula, P.; Saba, J.D.
Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren
Trends Mol. Med.
13
210-217
2007
Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Homo sapiens, Leishmania major, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team