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Information on EC 4.1.1.94 - ethylmalonyl-CoA decarboxylase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.94 ethylmalonyl-CoA decarboxylase
IUBMB Comments
The enzyme, which exists in all vertebrates, decarboxylates ethylmalonyl-CoA, a potentially toxic compound that is formed in low amounts by the activity of EC 6.4.1.2, acetyl-CoA carboxylase and EC 6.4.1.3, propanoyl-CoA carboxylase. It prefers the S isomer, and can decarboxylate (R)-ethylmalonyl-CoA with lower efficiency. cf. EC 7.2.4.1, (S)-methylmalonyl-CoA decarboxylase (sodium-transporting).
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
echdc1, ethylmalonyl-coa decarboxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-ethylmalonyl-CoA = butanoyl-CoA + CO2
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PATHWAY SOURCE
PATHWAYS
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