Reference on EC 4.1.1.9 - malonyl-CoA decarboxylase and Organism(s) Homo sapiens and UniProt Accession O95822
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Mulder, H.; Lu, D.; Finley IV, J.; An, J.; Cohen, J.; Antinozzi, P.A.; McGarry, J.D.; Newgard, C.B.
Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
J. Biol. Chem.
276
6479-6484
2001
Homo sapiens
Gao, J.; Waber, L.; Bennett, M.J.; Gibson, K.M.; Cohen, J.C.
Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase
J. Lipid Res.
40
178-182
1999
Homo sapiens
Zhou, D.; Yuen, P.; Chu, D.; Thon, V.; McConnell, S.; Brown, S.; Tsang, A.; Pena, M.; Russell, A.; Cheng, J.F.; Nadzan, A.M.; Barbosa, M.S.; Dyck, J.R.B.; Lopaschuk, G.D.; Yang, G.
Expression, purification, and characterization of human malonyl-CoA decarboxylase
Protein Expr. Purif.
34
261-269
2004
Homo sapiens
Kuhl, J.E.; Ruderman, N.B.; Musi, N.; Goodyear, L.J.; Patti, M.E.; Crunkhorn, S.; Dronamraju, D.; Thorell, A.; Nygren, J.; Ljungkvist, O.; Degerblad, M.; Stahle, A.; Brismar, T.B.; Andersen, K.L.; Saha, A.K.; Efendic, S.; Bavenholm, P.N.
Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
Am. J. Physiol. Endocrinol. Metab.
290
E1296-E1303
2006
Homo sapiens
Cheng, J.F.; Chen, M.; Wallace, D.; Tith, S.; Haramura, M.; Liu, B.; Mak, C.C.; Arrhenius, T.; Reily, S.; Brown, S.; Thorn, V.; Harmon, C.; Barr, R.; Dyck, J.R.; Lopaschuk, G.D.; Nadzan, A.M.
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors
J. Med. Chem.
49
1517-1525
2006
Homo sapiens
Lo, M.C.; Wang, M.; Kim, K.W.; Busby, J.; Yamane, H.; Zondlo, J.; Yuan, C.; Young, S.W.; Xiao, S.H.
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase
Anal. Biochem.
376
122-130
2008
Homo sapiens
Saggerson, D.
Malonyl-CoA, a key signaling molecule in mammalian cells
Annu. Rev. Nutr.
28
253-272
2008
Homo sapiens
Ussher, J.R.; Lopaschuk, G.D.
The malonyl CoA axis as a potential target for treating ischaemic heart disease
Cardiovasc. Res.
79
259-268
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Lopez, M.; Vidal-Puig, A.
Brain lipogenesis and regulation of energy metabolism
Curr. Opin. Clin. Nutr. Metab. Care
11
483-490
2008
Homo sapiens
Bouzakri, K.; Austin, R.; Rune, A.; Lassman, M.E.; Garcia-Roves, P.M.; Berger, J.P.; Krook, A.; Chibalin, A.V.; Zhang, B.B.; Zierath, J.R.
Malonyl coenzyme A decarboxylase regulates lipid and glucose metabolism in human skeletal muscle
Diabetes
57
1508-1516
2008
Homo sapiens
Li, J.; Lei, B.; Liu, H.; Li, S.; Yao, X.; Liu, M.; Gramatica, P.
QSAR study of malonyl-CoA decarboxylase inhibitors using GA-MLR and a new strategy of consensus modeling
J. Comput. Chem.
29
2636-2647
2008
Homo sapiens
Yatscoff, M.A.; Jaswal, J.S.; Grant, M.R.; Greenwood, R.; Lukat, T.; Beker, D.L.; Rebeyka, I.M.; Lopaschuk, G.D.
Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart
Pediatr. Res.
64
643-647
2008
Homo sapiens
Singh, P.; Kumar, R.; Sharma, B.; Prabhakar, Y.
Topological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl) amide derivatives
J. Enzyme Inhib. Med. Chem.
24
77-85
2009
Homo sapiens
Zhou, W.; Tu, Y.; Simpson, P.J.; Kuhajda, F.P.
Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells
Oncogene
28
2979-2987
2009
Homo sapiens
Tang, H.; Yan, Y.; Feng, Z.; de Jesus, R.K.; Yang, L.; Levorse, D.A.; Owens, K.A.; Akiyama, T.E.; Bergeron, R.; Castriota, G.A.; Doebber, T.W.; Ellsworth, K.P.; Lassman, M.E.; Li, C.; Wu, M.S.; Zhang, B.B.; Chapman, K.T.; Mills, S.G.; Berger, J.P.; Pasternak, A.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities
Bioorg. Med. Chem. Lett.
20
6088-6092
2010
Homo sapiens
Polinati, P.P.; Valanne, L.; Tyni, T.
Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations
Brain Dev.
37
107-113
2015
Homo sapiens (O95822)
Aparicio, D.; Perez-Luque, R.; Carpena, X.; Diaz, M.; Ferrer, J.C.; Loewen, P.C.; Fita, I.
Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase
J. Biol. Chem.
288
11907-11919
2013
Homo sapiens (O95822), Homo sapiens
Froese, D.S.; Forouhar, F.; Tran, T.H.; Vollmar, M.; Kim, Y.S.; Lew, S.; Neely, H.; Seetharaman, J.; Shen, Y.; Xiao, R.; Acton, T.B.; Everett, J.K.; Cannone, G.; Puranik, S.; Savitsky, P.; Krojer, T.; Pilka, E.S.; Kiyani, W.; Lee, W.H.; Marsden, B.D.; von Delft, F.; Allerston, C.K.; Spagnolo, L.; Gileadi, O.; , M.
Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations
Structure
21
1182-1192
2013
Agrobacterium vitis (B9K0V9), Agrobacterium vitis, Cupriavidus metallidurans (Q1LJK6), Cupriavidus metallidurans, Cupriavidus metallidurans CH34 (Q1LJK6), Homo sapiens (O95822), Homo sapiens, Rhodopseudomonas palustris
Hwang, I.W.; Makishima, Y.; Suzuki, T.; Kato, T.; Park, S.; Terzic, A.; Chung, S.K.; Park, E.Y.
Phosphorylation of Ser-204 and Tyr-405 in human malonyl-CoA decarboxylase expressed in silkworm Bombyx mori regulates catalytic decarboxylase activity
Appl. Microbiol. Biotechnol.
99
8977-8986
2015
Homo sapiens (O95822), Homo sapiens
Jagdale, D.; Ramaa, C.
Design, synthesis and in vitro evaluation of some small molecules malonyl CoA decarboxylase inhibitors containing pyrazoline scaffold and study of their binding interactions with malonyl CoA decarboxylase via preliminary docking simulation
Med. Chem. Res.
26
2127-2140
2017
Homo sapiens (O95822)
-