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Information on EC 4.1.1.72 - branched-chain-2-oxoacid decarboxylase and Organism(s) Saccharomyces cerevisiae and UniProt Accession Q07471

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.72 branched-chain-2-oxoacid decarboxylase
IUBMB Comments
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.
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Saccharomyces cerevisiae
UNIPROT: Q07471
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
bckad, ydl080c, alpha-keto acid decarboxylase, branched-chain alpha-keto acid decarboxylase, branched-chain 2-keto acid decarboxylase, mtkdc, branched-chain keto acid decarboxylase, branched-chain oxo acid decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
thiamine metabolism regulatory protein
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BCKA
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-
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branched-chain 2-oxoacid decarboxylase
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-
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branched-chain alpha-keto acid decarboxylase
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-
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branched-chain keto acid decarboxylase
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-
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branched-chain oxo acid decarboxylase
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decarboxylase, branched-chain oxo acid
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.
CAS REGISTRY NUMBER
COMMENTARY hide
63653-19-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dickinson, J.R.; Lanterman, M.M.; Danner, D.J.; Pearson, B.M.; Sanz, P.; Harrison, S.J.; Hewlins, M.J.
A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae
J. Biol. Chem.
272
26871-26878
1997
Saccharomyces cerevisiae (Q07471), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dickinson, J.R.; Harrison, S.J.; Dickinson, J.A.; Hewlins, M.J.
An investigation of the metabolism of isoleucine to active amyl alcohol in Saccharomyces cerevisiae
J. Biol. Chem.
275
10937-10942
2000
Saccharomyces cerevisiae (Q07471), Saccharomyces cerevisiae
Manually annotated by BRENDA team