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IUBMB CommentsThe enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cis-aconitate decarboxylase, cis-aconitic acid decarboxylase, aconitate decarboxylase,
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Aconitate decarboxylase
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cis-Aconitic acid decarboxylase
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Decarboxylase, aconitate
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cis-aconitate carboxy-lyase (itaconate-forming)
The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.
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cis-aconitate
itaconate + CO2
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UniProt
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IRG1_MOUSE
488
0
53758
Swiss-Prot
other Location (Reliability: 3)
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Michelucci, A.; Cordes, T.; Ghelfi, J.; Pailot, A.; Reiling, N.; Goldmann, O.; Binz, T.; Wegner, A.; Tallam, A.; Rausell, A.; Buttini, M.; Linster, C.L.; Medina, E.; Balling, R.; Hiller, K.
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Proc. Natl. Acad. Sci. USA
110
7820-7825
2013
Homo sapiens (A6NK06), Mus musculus (P54987)
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