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IUBMB CommentsThe enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cis-aconitate decarboxylase, cis-aconitic acid decarboxylase, aconitate decarboxylase,
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Aconitate decarboxylase
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cis-Aconitic acid decarboxylase
Decarboxylase, aconitate
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cis-Aconitic acid decarboxylase
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cis-Aconitic acid decarboxylase
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cis-aconitate carboxy-lyase (itaconate-forming)
The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase.
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cis-aconitate
itaconate + CO2
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Brucellosis
Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.
Infections
ACOD1 in immunometabolism and disease.
Infections
Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.
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UniProt
brenda
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brenda
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in human gastric cancer cell lines SGC7901
brenda
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brenda
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IRG1_HUMAN
481
0
52628
Swiss-Prot
other Location (Reliability: 3)
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55000
SDS-PAGE, Flag-Irg1
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espressed as recombinant protein in Escherichia coli
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purification with Ni-NTA resin under denaturing conditions
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Li, M.; Zhang, H.; Hong, L.; Jin, Y.; Gong, T.; Sun, L.; Yang, J.; Zheng, X.
Preparation and characterization of a novel monoclonal antibody specific to human CAD protein
Hybridoma
28
129-132
2009
Aspergillus terreus, Homo sapiens
brenda
Michelucci, A.; Cordes, T.; Ghelfi, J.; Pailot, A.; Reiling, N.; Goldmann, O.; Binz, T.; Wegner, A.; Tallam, A.; Rausell, A.; Buttini, M.; Linster, C.L.; Medina, E.; Balling, R.; Hiller, K.
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
Proc. Natl. Acad. Sci. USA
110
7820-7825
2013
Homo sapiens (A6NK06), Mus musculus (P54987)
brenda