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Information on EC 4.1.1.52 - 6-methylsalicylate decarboxylase for references in articles please use BRENDA:EC4.1.1.52
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
6-Methylsalicylic acid (2,6-cresotic acid) decarboxylase, 6-Methylsalicylic acid decarboxylase, 6-MSA decarboxylase, AOL_s00215g281, Decarboxylase, 6-methylsalicylate, PatG,
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6-Methylsalicylic acid (2,6-cresotic acid) decarboxylase
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6-Methylsalicylic acid decarboxylase
6-MSA decarboxylase
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Decarboxylase, 6-methylsalicylate
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6-Methylsalicylic acid decarboxylase
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6-Methylsalicylic acid decarboxylase
T1PRE6
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6-Methylsalicylic acid decarboxylase
T1PRE6
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AOL_s00215g281
gene name
AOL_s00215g281
gene name
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PatG
T1PRE6
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6-methylsalicylate = 3-methylphenol + CO2
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6-methylsalicylate carboxy-lyase (3-methylphenol-forming)
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3-Bromoorsellinic acid
1,3-Dihydroxy-2-bromo-5-methylbenzene + CO2
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at 6% the activity with 6-methylsalicylic acid
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6-Ethylsalicylic acid
3-Ethyl-1-hydroxybenzene + CO2
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at 100% of the activity with 6-methylsalicylic acid
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6-methylsalicylate
3-methylphenol + CO2
6-Methylsalicylate
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enzyme catalyzes the first step in the conversion of 6-methylsalicylic acid into patulin
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6-Methylsalicylic acid
3-Cresol + CO2
Homoorsellinic acid
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at 100% of the activity with 6-methylsalicylic acid
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Orsellinic acid
1,3-Dihydroxy-5-methylbenzene + CO2
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at 80% of the activity with 6-methylsalicylic acid
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6-methylsalicylate
3-methylphenol + CO2
T1PRE6
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6-methylsalicylate
3-methylphenol + CO2
T1PRE6
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6-Methylsalicylic acid
3-Cresol + CO2
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6-Methylsalicylic acid
3-Cresol + CO2
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6-methylsalicylate
3-methylphenol + CO2
6-Methylsalicylate
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enzyme catalyzes the first step in the conversion of 6-methylsalicylic acid into patulin
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6-methylsalicylate
3-methylphenol + CO2
T1PRE6
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6-methylsalicylate
3-methylphenol + CO2
T1PRE6
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2-Hydroxy-1-naphthoic acid
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3-methylsalicylic acid
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4-methylsalicylic acid
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6-Methylanthranilic acid
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6-Methylsalicylic acid
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diethyl dicarbonate
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10 mM, complete inhibition
NaNO3
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10 mM, 20% inhibition
Rose bengal
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photooxidation
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0.15
3-bromoorsellinic acid
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0.01
6-Ethylsalicylic acid
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6-methylsalicylic acid
0.007
6-Methylsalicylic acid
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0.04
Homoorsellinic acid
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UniProt
brenda
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UniProt
brenda
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T1PRE6
UniProt
brenda
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T1PRE6
UniProt
brenda
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brenda
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brenda
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grown in Czapek medium containing cycloheximide, no activity in rich germinating medium
brenda
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physiological function
a mutant lacking the enzyme activity shows huge accumulation of 6-methylsalicylic acid in the cultural broth. 6-methylsalicylic acid and m-cresol display significant nematicidal activity toward root-knot nematodes Meloidogyne incognita
physiological function
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a mutant lacking the enzyme activity shows huge accumulation of 6-methylsalicylic acid in the cultural broth. 6-methylsalicylic acid and m-cresol display significant nematicidal activity toward root-knot nematodes Meloidogyne incognita
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AR281_ARTOA
Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)
325
0
36066
Swiss-Prot
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43000
T1PRE6
x * 43000, V5 His-tagged enzyme, SDS-PAGE
56000 - 60000
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gel filtration, sucrose density gradient sedimentation
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T1PRE6
x * 43000, V5 His-tagged enzyme, SDS-PAGE
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x * 43000, V5 His-tagged enzyme, SDS-PAGE
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unstable in solutions of low ionic strength
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photooxidation in presence of rose Bengal is prevented in presence of substrate or 2-hydroxy-6-methylsalicylic acid
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4703
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-15°C, pH 7.5, 50% glycerol, 5% w/v (NH4)2SO4, stable for several months
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-25°C, pH 7.5, without glycerol, stable for at least 1 year
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the enzyme is strongly expressed during patulin production whereas it is very weakly expressed in non-patulin permissive conditions
when Aspergillus clavatus is grown under restrictive conditions (MEM) which does not support patulin production, the expression of the enzyme is inhibited
the enzyme is strongly expressed during patulin production whereas it is very weakly expressed in non-patulin permissive conditions
T1PRE6
the enzyme is strongly expressed during patulin production whereas it is very weakly expressed in non-patulin permissive conditions
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when Aspergillus clavatus is grown under restrictive conditions (MEM) which does not support patulin production, the expression of the enzyme is inhibited
T1PRE6
when Aspergillus clavatus is grown under restrictive conditions (MEM) which does not support patulin production, the expression of the enzyme is inhibited
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Light, R.J.
6-Methylsalicylic acid decarboxylase from Penicillium patulum
Biochim. Biophys. Acta
191
430-438
1969
Penicillium griseofulvum
brenda
Slater, G.P.; Child, J.J.; Hogge, L.R.
The decarboxylation of 6-methylsalicylic acid by Valsa friesii
Can. J. Microbiol.
19
1169-1171
1973
Valsa friesii
brenda
Light, R.J.; Vogel, G.
6-Methylsalicylic acid (2,6-cresotic acid) decarboxylase
Methods Enzymol.
43
530-540
1975
Penicillium griseofulvum
brenda
Snini, S.P.; Tadrist, S.; Laffitte, J.; Jamin, E.L.; Oswald, I.P.; Puel, O.
The gene PatG involved in the biosynthesis pathway of patulin, a food-borne mycotoxin, encodes a 6-methylsalicylic acid decarboxylase
Int. J. Food Microbiol.
171
77-83
2014
Aspergillus clavatus, Aspergillus clavatus (T1PRE6), Aspergillus clavatus NRRL 1980 (T1PRE6)
brenda
Xu, Z.; Chen, Y.; Song, T.; Zeng, Z.; Yan, N.; Zhang, K.; Niu, X.
Nematicidal key precursors for the biosynthesis of morphological regulatory arthrosporols in the nematode-trapping fungus Arthrobotrys oligospora
J. Agric. Food Chem.
64
7949-7956
2016
Arthrobotrys oligospora, Arthrobotrys oligospora (G1XU02), Arthrobotrys oligospora DSM 1491 (G1XU02)
brenda
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4.1.1.52 6-methylsalicylate decarboxylase
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